Precipitating Antibodies Against Organic Dust Antigens in Human Sera by Counterimmunoelectrophoresis

Kawai, Takeshi; Salvaggio, John E.; Arquembourg, P.C.; Marsh, David G.

doi:10.1378/chest.64.4.420

Cited by 35 publications

(17 citation statements)

References 22 publications

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“…Thus certain subjects with indirect or low levels of exposure may have been included in the nonexposure group (misclassification error). The results on the role of precipitins as an exposure indicator concur with those of other authors (44)(45)(46).…”

Section: Discussionsupporting

confidence: 91%

Respiratory symptoms and pulmonary function of workers exposed to cork dust, toluene diisocyanate and conidia.

Alegre¹,

Morell²,

Pleguezuelos³

1990

Scand J Work Environ Health

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Section: Discussionsupporting

confidence: 91%

Respiratory symptoms and pulmonary function of workers exposed to cork dust, toluene diisocyanate and conidia.

Alegre¹,

Morell²,

Pleguezuelos³

1990

Scand J Work Environ Health

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“…To check this method, 94 healthy controls were examined, of which 5 (5.3%) were defined as positive to M. faeni or T. vulgaris [15] even after treat ment with sodium citrate [16]. This inci dence is close to the results reported by Phanuphak et al [13] and Kawai et al [12] (12-18% and 11.8% to the M. faeni antigen in normal volunteers, respectively).…”

Section: Discussionsupporting

confidence: 64%

“…Ouchterlony's double immunodiffusion method has been reported to be less sensitive, and some modifications by concentration of the patient's serum or changing the speci fications of wells on agar gel plates has been attempted [11]. Counterimmunoelectrophoresis used in this series has been de veloped recently and is recognized as hav ing a sufficiently high sensitivity [12][13][14]. However, the problem of the biological false positive reaction in this method has not yet been solved.…”

Section: Discussionmentioning

confidence: 99%

Incidence of Serum-Precipitating Antibodies to Farmer’s Lung Antigens in Hokkaido

Homma¹,

Terai²,

Matsuzaki³

1986

Respiration

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The prevalence of serum-precipitating antibodies toMicropolyspora faeni and Thermoactinomyces vulgaris was studied by immunoelectrophoresis in 442 dairy farmers living in Hokkaido, the northernmost district of Japan. The prevalence rates of antibodies to M.faeni and T. vulgaris were 24.2 and 11.6%, respectively. The rate of antibodies to M.faeni was higher among females than males. This difference may be due to the large number of nonsmokers among females. Prevalence of antibodies to M.faeni or M. faeni and T. vulgaris was associated with a higher hay acreage and longer working hours per day in the cowshed, and not to the size of the dairy herd. These results were partly different from those reported from other countries.

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“…In the chronic disease, diffuse interstitial fibrosis is common, and cystic changes may be evident. In addition, experimental animal models have been developed to elucidate potential pathogenic mechanisms involved in the disease (428,633 (285,315,375,480,632). Following a single attack, these antibodies may persist for variable periods; however, in most patients, these antibodies are lost after approximately 3 years.…”

Section: Opportunistic Pathogenic Actinomycetesmentioning

confidence: 99%

The medically important aerobic actinomycetes: epidemiology and microbiology

1994

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The aerobic actinomycetes are soil-inhabiting microorganisms that occur worldwide. In 1888, Nocard first recognized the pathogenic potential of this group of microorganisms. Since then, several aerobic actinomycetes have been a major source of interest for the commercial drug industry and have proved to be extremely useful microorganisms for producing novel antimicrobial agents. They have also been well known as potential veterinary pathogens affecting many different animal species. The medically important aerobic actinomycetes may cause significant morbidity and mortality, in particular in highly susceptible severely immunocompromised patients, including transplant recipients and patients infected with human immunodeficiency virus. However, the diagnosis of these infections may be difficult, and effective antimicrobial therapy may be complicated by antimicrobial resistance. The taxonomy of these microorganisms has been problematic. In recent revisions of their classification, new pathogenic species have been recognized. The development of additional and more reliable diagnostic tests and of a standardized method for antimicrobial susceptibility testing and the application of molecular techniques for the diagnosis and subtyping of these microorganisms are needed to better diagnose and treat infected patients and to identify effective control measures for these unusual pathogens. We review the epidemiology and microbiology of the major medically important aerobic actinomycetes.

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Precipitating Antibodies Against Organic Dust Antigens in Human Sera by Counterimmunoelectrophoresis

Cited by 35 publications

References 22 publications

Respiratory symptoms and pulmonary function of workers exposed to cork dust, toluene diisocyanate and conidia.

Respiratory symptoms and pulmonary function of workers exposed to cork dust, toluene diisocyanate and conidia.

Incidence of Serum-Precipitating Antibodies to Farmer’s Lung Antigens in Hokkaido

The medically important aerobic actinomycetes: epidemiology and microbiology

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