Precipitated droplets in-situ cross-linking polymerization towards hydrogel beads for ultrahigh removal of positively charged toxins

Yin, Jiarui; Sun, Wei; Song, Xin; Ji, Haifeng; Yang, Yuliang; Sun, Shudong; Zhao, Weifeng; Zhao, Changsheng

doi:10.1016/j.seppur.2019.116497

Cited by 20 publications

(9 citation statements)

References 53 publications

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“…In order to further investigate the adsorption kinetics of the hydrogel spheres, the adsorption capacities at different time intervals were fitted by pseudo-first-order and pseudo-second-order kinetic models; the fitting results are shown in Figure S13 and Table S5. The pseudo-first-order model assumes that the adsorption process is controlled by the diffusion step, and the pseudo-first-order model assumes the process to be controlled by the chemisorption step. , Except for the CCSs, the adsorption kinetics of endotoxin for the ET-CCSPDs, CCSPDs, and ET-CCSs fitted the pseudo-first-order and pseudo-second-order kinetic models well ( R 2 > 0.987), thus both diffusion and chemisorption mechanisms coexist in the adsorption of endotoxin for the spheres.…”

Section: Resultsmentioning

confidence: 89%

“…The pseudo-first-order model assumes that the adsorption process is controlled by the diffusion step, and the pseudo-first-order model assumes the process to be controlled by the chemisorption step. 67,68 Except for the CCSs, the adsorption kinetics of endotoxin for the ET-CCSPDs, CCSPDs, and ET-CCSs fitted the pseudo-first-order and pseudo-second-order kinetic models well (R 2 > 0.987), thus both diffusion and chemisorption mechanisms coexist in the adsorption of endotoxin for the spheres.…”

Section: Hemocompatibility and Anticoagulationmentioning

confidence: 90%

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Ultraporous Polyquaternium-Carboxylated Chitosan Composite Hydrogel Spheres with Anticoagulant, Antibacterial, and Rapid Endotoxin Removal Profiles for Sepsis Treatment

Liu

Jiang

et al. 2022

Biomacromolecules

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Hemoperfusion is an important method to remove endotoxins and save the lives of patients with sepsis. However, the current adsorbents for hemoperfusion have disadvantages of insufficient endotoxin adsorption capacity, poor blood compatibility, and so on. Herein, we proposed a novel emulsion templating (ET) method to prepare ultraporous and double-network carboxylated chitosan (CCS)-poly(diallyl dimethylammonium chloride) (PDDA) hydrogel spheres (ET-CCSPD), bearing both negative and positive charges. CCS was introduced to balance the strong positive charges of PDDA to improve hemocompatibility, and emulsion templates endowed the adsorbent with an ultraporous structure for enhanced adsorption efficacy. The ET-CCSPDs neither damaged blood cells nor activated complement responses. In addition, the activated partial thromboplastin time (APTT) was prolonged to 8.5 times, which was beneficial for reducing the injection of anticoagulant in patients. The ET-CCSPDs had excellent scavenging performance against bacteria and endotoxin, with removal ratios of 96.7% for E. coli and 99.8% for S. aureus, respectively, and the static removal ratio of endotoxin in plasma was as high as 99.1% (C 0 = 5.50 EU/mL, critical illness level). An adsorption cartridge filled with the ET-CCSPDs could remove 84.7% of endotoxin within 1 h (C 0 = 100 EU/mL in PBS). Interestingly, the ET-CCSPDs had a good inhibitory effect on the cytokines produced by endotoxin-mediated septic blood. By developing the ET method to prepare ultraporous and double-network adsorbents, the problems of low adsorption efficiency and poor blood compatibility of traditional endotoxin adsorbents have been solved, thus opening a new route to fabricate absorbents for blood purification.

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Section: Resultsmentioning

confidence: 89%

Section: Hemocompatibility and Anticoagulationmentioning

confidence: 90%

Ultraporous Polyquaternium-Carboxylated Chitosan Composite Hydrogel Spheres with Anticoagulant, Antibacterial, and Rapid Endotoxin Removal Profiles for Sepsis Treatment

Liu

Jiang

et al. 2022

Biomacromolecules

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“…This could be the reason of the crosslinking of TA with polymer chain which generate more pore structure. The high BET surface area and pore volume of THAM‐2 could benefit the contact between the adsorption sites and adsorbates, and then enhance the adsorption capacity 45,46 …”

Section: Resultsmentioning

confidence: 99%

“…The high BET surface area and pore volume of THAM-2 could benefit the contact between the adsorption sites and adsorbates, and then enhance the adsorption capacity. 45,46…”

Section: Porosity Analysismentioning

confidence: 99%

Hydroxyethyl cellulose hydrogel modified with tannic acid as methylene blue adsorbent

Feng

Zhang

Kang

et al. 2020

J of Applied Polymer Sci

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This work developed an effective way to improve the methylene blue (MB) adsorption performance of cellulose-based hydrogel by modified with tannic acid (TA). HEC-co-p(AA-AM)/TA hydrogel was synthesized by grafting of acrylic acid (AA) and acrylamide (AM) onto hydroxyethyl cellulose (HEC), followed by modified with TA. Fourier transform infrared spectroscopy manifested that AA and AM were successfully grafted onto the hydrogel, and TA was immobilized in the hydrogel. Field emission scanning electron microscope demonstrated that the hydrogel after TA modification had a homogeneous pore structure. Brunauer-Emmett-Teller (BET) surface areas, total pore volume, and average pore diameters of the hydrogel are 11.821 m 2 g −1 , 0.0641 cm 3 g −1 , and 2.538 nm, respectively. The high swelling ratio (1179.2 g g −1 in deionized water) was in favor of the MB adsorption. The results of the adsorption experiments illustrated that HEC-cop (AA/AM) hydrogel had excellent MB adsorption performance. As the pH increases, the electrostatic attraction is enhanced, and the adsorption capacity is improved. The adsorption process was more fit with pseudo-second-order kinetics, and the maximum adsorption capacity (3438.27 mg g −1) was determined by Langmuir model. Thermodynamic studies suggested that the adsorption process is spontaneous, exothermic, and entropy reduction. X-ray photoelectron spectroscopy analysis confirmed that MB molecules were reacted with the oxygen atoms in hydroxyl and carboxyl groups by ion-exchange. High reusability demonstrated that the hydrogel could be a potential candidate for removal cationic dye from industrial effluents.

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“…In addition, there are a lot of researches in the field of environmental science on the use of hydrogels to remove heavy metals and other pollutants can also be considered for application in food science. [486,[644][645][646][647][648][649][650][651] In these studies, in addition to focusing on the adsorption and removal performance, the mechanical strength of the hydrogel is also important. Hence, hybrid hydrogels are ideal for more attentions.…”

Section: Adsorption and Removalmentioning

confidence: 99%

Hydrogel: Diversity of Structures and Applications in Food Science

Jia

Luo

2021

Food Reviews International

102

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Hydrogels are a series of soft and wet materials with three dimensions of crosslinked networks. Hydrogels have attracted great attention due to their diverse functional properties, and their wide range of applications, such as in soft robots and actuators, stretched electronic devices, tissue engineering materials, controlled-release drug delivery vehicles, biomedicine materials, food science, and (bio)sensors. In general, there are four core concerns in hydrogel science, including the polymer source, structure fabrication, gel function, and gel applications. According to the logic that the "structure determines function", it is believed that rational design of structures can effectively regulate the functions and applications of hydrogels. Hence, in the current review, "structure" as the core topic will be highly regarded, and the crosslinking mechanisms and structural diversity of hydrogels are comprehensively summarized. Additionally, hydrogels also show their great application potential in food science. Hence, the current review also pays more attention to the application of hydrogels in food nutrition and health, food engineering and processing, and food safety. It is whished that this review not only serves as a reference for improving the comprehensive understanding of the structural design of hydrogels but also provides a forward-looking idea for hydrogel applications in food science.

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Precipitated droplets in-situ cross-linking polymerization towards hydrogel beads for ultrahigh removal of positively charged toxins

Cited by 20 publications

References 53 publications

Ultraporous Polyquaternium-Carboxylated Chitosan Composite Hydrogel Spheres with Anticoagulant, Antibacterial, and Rapid Endotoxin Removal Profiles for Sepsis Treatment

Ultraporous Polyquaternium-Carboxylated Chitosan Composite Hydrogel Spheres with Anticoagulant, Antibacterial, and Rapid Endotoxin Removal Profiles for Sepsis Treatment

Hydroxyethyl cellulose hydrogel modified with tannic acid as methylene blue adsorbent

Hydrogel: Diversity of Structures and Applications in Food Science

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