Precentral and inferior prefrontal hypoactivation during facial emotion recognition in patients with schizophrenia: A functional near-infrared spectroscopy study

Watanuki, Toshio; Matsuo, Koji; Egashira, Kazuteru; Nakashima, Mami; Harada, Kazuaki; Nakano, Masayuki; Matsubara, Takehiro; Takahashi, Kanji; Watanabe, Yoshifumi

doi:10.1016/j.schres.2015.11.012

Cited by 27 publications

(28 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Besides, dysfunction of facial emotional recognition involves precentral and inferior prefrontal area in schizophrenic patients compared to healthy controls 48 . Whether PICK1 also takes a part in the management of emotions via frontal area in schizophrenic patients remains to be studied.…”

Section: Discussionmentioning

confidence: 97%

PICK1 Genetic Variation and Cognitive Function in Patients with Schizophrenia

Chen

Lin

Huang

et al. 2017

Sci Rep

View full text Add to dashboard Cite

The gene of protein interacting with C kinase 1 alpha (PICK1) has been implicated in schizophrenia, nevertheless, conflicting results existed. However, its role in cognitive function remains unclear. Besides, cognitive deficits impair the long-term outcome. We explored whether the polymorphisms of PICK1 (rs2076369, rs3952) affected cognitive functions in schizophrenic patients. We analyzed 302 patients and tested the differences of cognitive functions, clinical symptoms between genetic groups. We also used general linear model to analyze the effect of PICK1 genetic polymorphisms on cognitive functions. After adjustment for gender, age, education, the patients with rs2076369 G/T genotype showed better performance than T/T homozygotes in the summary score, global composite score, neurocognitive composite score, category fluency subtest, WAIS-III-Digit Symbol Coding subtest, working memory, WMS-III-Spatial Span (backward) subtest, MSCEIT-managing emotions branch (p = 0.038, 0.025, 0.046, 0.036, 0.025, 0.027, 0.035, 0.028, respectively). G/G homozygotes performed better than T/T in category fluency subtest (p = 0.049). A/A homozygotes of rs3952 performed better than G/G in trail making A subtest (p = 0.048). To our knowledge, this is the first study to indicate that PICK1 polymorphisms may associate with cognitive functions in schizophrenic patients. Further replication studies in healthy controls or other ethnic groups are warranted.

show abstract

Section: Discussionmentioning

confidence: 97%

PICK1 Genetic Variation and Cognitive Function in Patients with Schizophrenia

Chen

Lin

Huang

et al. 2017

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Choudhary et al [60] observed hypoactivation of the fusiform gyrus and bilateral dorsolateral prefrontal cortex in first-episode patients. Using functional near-infrared spectroscopy, Watanuki et al [61] reported lower activation of the right precentral and inferior frontal areas in SZ during an emotional face task.…”

Section: Neural Correlates Of Facial Emotion Processingmentioning

confidence: 99%

Facial emotion processing in schizophrenia: a review of behavioural and neural correlates

Grave¹,

Soares²,

Martins³

et al. 2017

IJCNMH

View full text Add to dashboard Cite

Schizophrenia is one of the most severe psychiatric conditions, often associated with deficits in social cognition. Social cognition deficits are predictors of functionality in patients and involve theory of mind, attributional style, social perception, and emotional processing. In particular, facial emotion processing (an important domain of emotional processing) seems to be particularly related to cognitive and social functioning, and to positive and negative symptoms. Patients with schizophrenia have difficulties in processing emotional faces; however, those impairments are still far from fully understood. In this review, we addressed the behavioural and neural correlates of facial emotion processing in schizophrenia. Despite studies showing impairments in both positive and negative faces, the most consistent findings involved negative faces. Moreover, patients with schizophrenia showed abnormalities in the social brain neural circuit during facial emotion processing. While some studies described hypoactivation of brain areas related to emotional processing, such as the amygdala, others reported hyperactivation, leading to a high number of inconsistencies. The findings are limited by the experimental designs used, and the clinical and demographic characteristics of patients. Despite such variable findings, there has been growing interest in developing psychosocial interventions focused directly on social cognitive impairments in schizophrenia, with potential impact on patient's ability to perceive emotional faces. We provide a critical perspective on current evidence and suggest new pathways of research. The understanding of the mechanisms underlying facial emotion processing in schizophrenia could enhance functionality and quality of life by providing innovative approaches to the interpersonal difficulties patients frequently experience.

show abstract

“…The inability to recognize facial affect is an important predictor of functional outcome in schizophrenia, and it hinders communication considerably [4]. It is still unclear if these social deficits are different between genders, but the neural pathways involved appear to be the same [3,4,7]. Emotion recognition from facial expression is affected both for explicit and implicit facial emotions, such as fear, happiness, anger and surprise, and this condition is associated with poorer problem-solving skills and social performance [28].…”

Section: Social Cognitive Impairment In Schizophreniamentioning

confidence: 99%

“…However, they seem to have a dysregulated emotion regulation process, which causes them to present an exaggerated or diminished reaction, even when that reaction is the correct one for the situation [fear, anger, happiness, etc.] [7,24]. Cognitive appraisal, which is the mean human beings use subconsciously to regulate emotions before expressing them, in order to deliver a reaction of adequate level, has been observed to be less frequently used by schizophrenic patients [2,19].…”

Section: Social Cognitive Impairment In Schizophreniamentioning

confidence: 99%

“…Experience sharing, face and emotional recognition, getting insight about people's thoughts from their expressions, and emotional reactions are among some of the components of social cognition [2,4,5]. It is now considered a neuropsychological domain, along with processing speed, attention, memory, learning, reasoning and problem solving, and is related to many different brain areas and complex pathways [6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Schizophrenia and Social Cognition: A Review of Concepts and Treatment Options

Peñaherrera¹

2016

J Socialomics

View full text Add to dashboard Cite

Social cognition is a neuropsychological domain of the human psyche, in charge of processing the information about ourselves and the people that surrounds us. This includes recognition of faces and emotions, facial expression, experience sharing, reactions, and inferring people's mental processes. Schizophrenia is the most severe condition in the psychotic disease range, presenting with both positive and negative symptoms. Social cognition is affected in schizophrenic patients, impairing their ability to function properly in society. Recent research has been done in the areas of emotion and face recognition in schizophrenics, with the aim of improving treatment options through various neuropsychiatric approaches. In the medical field, oxytocin has been discovered to be a key molecule in mediating human social performance, and its use is being studied for improving social cognition in schizophrenia. We offer a review and update on the main concepts of social cognition and its disturbances caused by schizophrenia, along with the treatment options available and the direction in which future research is heading.

show abstract

Precentral and inferior prefrontal hypoactivation during facial emotion recognition in patients with schizophrenia: A functional near-infrared spectroscopy study

Cited by 27 publications

References 26 publications

PICK1 Genetic Variation and Cognitive Function in Patients with Schizophrenia

PICK1 Genetic Variation and Cognitive Function in Patients with Schizophrenia

Facial emotion processing in schizophrenia: a review of behavioural and neural correlates

Schizophrenia and Social Cognition: A Review of Concepts and Treatment Options

Contact Info

Product

Resources

About