Preceding weak noise sharpens the frequency tuning and elevates the response threshold of the mouse inferior collicular neurons through GABAergic inhibition

Wang, Xin; Jen, Philip H.‐S.; Wu, Fei-Jian; Chen, Qi‐Cai

doi:10.1016/j.brainres.2007.07.002

Cited by 22 publications

(13 citation statements)

References 56 publications

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“…Previous studies have shown that there is no significant difference of neural processing in central auditory system between the albino mice and those of the control strains (CBA/CaJ) (Schleidt and Kickert-Magg, 1979;Shen et al, 1999;Wang et al, 2007;Xia et al, 2000;Yuan and Shen, 2005). We should therefore look at others reasons for the dramatic influence of RR upon the firing of IC units in our experiments.…”

Section: Putative Role Of Anesthetic and Gaba Inhibition In The Rate mentioning

confidence: 80%

Responses of inferior colliculus neurons to sounds presented at different rates in anesthetized albino mouse

Бибиков

Chen

2008

Hearing Research

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Section: Putative Role Of Anesthetic and Gaba Inhibition In The Rate mentioning

confidence: 80%

Responses of inferior colliculus neurons to sounds presented at different rates in anesthetized albino mouse

Бибиков

Chen

2008

Hearing Research

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“…All experiments were conducted with the approval of the Institutional Animal Care and Use Committee of Central China Normal University, Wuhan, Hubei, China. The surgical procedures for recording of sound-activated responses were basically the same as described in previous studies [44], [45]. Briefly, the flat head of a 2.0-cm nail was glued onto the exposed skull of each Nembutal anesthetized mouse (60–90 mg/kg b.w.)…”

Section: Methodsmentioning

confidence: 99%

“…During experiment, a 40 ms sound was delivered (at 2 pulses/s) from the loudspeaker placed 30 cm away from the animal and 60° contralateral to the recording site in order to maximally excite the recorded IC neuron [44], [45]. When an IC neuron was isolated (the first IC neuron, abbreviated as the IC ES neuron) with a pair of custom-made tungsten electrodes, its best frequency (BF) and minimum threshold (MT) were audio-visually measured by systematically changing the frequency and level of sound pulses.…”

Section: Methodsmentioning

confidence: 99%

Bilateral Collicular Interaction: Modulation of Auditory Signal Processing in Amplitude Domain

et al. 2012

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In the ascending auditory pathway, the inferior colliculus (IC) receives and integrates excitatory and inhibitory inputs from many lower auditory nuclei, intrinsic projections within the IC, contralateral IC through the commissure of the IC and from the auditory cortex. All these connections make the IC a major center for subcortical temporal and spectral integration of auditory information. In this study, we examine bilateral collicular interaction in modulating amplitude-domain signal processing using electrophysiological recording, acoustic and focal electrical stimulation. Focal electrical stimulation of one (ipsilateral) IC produces widespread inhibition (61.6%) and focused facilitation (9.1%) of responses of neurons in the other (contralateral) IC, while 29.3% of the neurons were not affected. Bilateral collicular interaction produces a decrease in the response magnitude and an increase in the response latency of inhibited IC neurons but produces opposite effects on the response of facilitated IC neurons. These two groups of neurons are not separately located and are tonotopically organized within the IC. The modulation effect is most effective at low sound level and is dependent upon the interval between the acoustic and electric stimuli. The focal electrical stimulation of the ipsilateral IC compresses or expands the rate-level functions of contralateral IC neurons. The focal electrical stimulation also produces a shift in the minimum threshold and dynamic range of contralateral IC neurons for as long as 150 minutes. The degree of bilateral collicular interaction is dependent upon the difference in the best frequency between the electrically stimulated IC neurons and modulated IC neurons. These data suggest that bilateral collicular interaction mainly changes the ratio between excitation and inhibition during signal processing so as to sharpen the amplitude sensitivity of IC neurons. Bilateral interaction may be also involved in acoustic-experience-dependent plasticity in the IC. Three possible neural pathways underlying the bilateral collicular interaction are discussed.

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“…One can speculate that the PMT projections to structures in the ascending auditory pathways could enhance responsiveness or transmission of the sensory information during the time when the motor components of the startle are being inhibited. Wang et al, (2007) have shown that a “pre-pulse” of weak noise can alter response thresholds and frequency tuning of IC cells. These changes are dependent on GABAergic circuits in the IC.…”

Section: Functional Implicationsmentioning

confidence: 99%

Cholinergic cells of the pontomesencephalic tegmentum: Connections with auditory structures from cochlear nucleus to cortex

2011

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Acetylcholine (ACh) is a neuromodulator that is likely to play a role in plasticity as well as other phenomena at many sites in the auditory system. The auditory cortex receives cholinergic innervation from the basal forebrain, whereas the cochlea receives cholinergic innervation from the superior olivary complex. Much of the remainder of the auditory pathways receives innervation from the pedunculopontine and laterodorsal tegmental nuclei, two nuclei referred to collectively as the pontomesencephalic tegmentum (PMT). The PMT provides the major source of ACh to the auditory thalamus and the midbrain, and is a substantial source (in addition to the superior olivary complex) of ACh in the cochlear nucleus. Individual cholinergic cells in the PMT often have axon branches that innervate multiple auditory nuclei, including nuclei on both sides of the brain as well as nuclei at multiple levels of the auditory system. The auditory cortex has direct axonal projections to the PMT cells, including cholinergic cells that project to the inferior colliculus or cochlear nucleus. The divergent projections of PMT cholinergic cells suggest widespread effects on the auditory pathways. These effects are likely to include plasticity as well as novelty detection, sensory gating, reward behavior, arousal and attention. Descending projections from the forebrain, including the auditory cortex, are likely to provide a high level of cognitive input to these cholinergic effects. Dysfunction associated with the cholinergic system may play a role in disorders such as tinnitus and schizophrenia.

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Preceding weak noise sharpens the frequency tuning and elevates the response threshold of the mouse inferior collicular neurons through GABAergic inhibition

Cited by 22 publications

References 56 publications

Responses of inferior colliculus neurons to sounds presented at different rates in anesthetized albino mouse

Responses of inferior colliculus neurons to sounds presented at different rates in anesthetized albino mouse

Bilateral Collicular Interaction: Modulation of Auditory Signal Processing in Amplitude Domain

Cholinergic cells of the pontomesencephalic tegmentum: Connections with auditory structures from cochlear nucleus to cortex

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