Precancerous lesions of the gallbladder mucosa.

Mukada, Takeo; Andoh, Noriaki; Matsushiro, Takashi

doi:10.1620/tjem.145.387

Cited by 14 publications

(8 citation statements)

References 4 publications

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“…16 We observed cholecystitis with hyperplasia in 8% cases. Cases of both adenomatous and adenomyomatous hyperplasia were included, although cases with simple epithelial hyperplasia including pseudostratification of epithelium were not considered.…”

Section: 7-10mentioning

confidence: 66%

Correlation of gallstone characteristics with mucosal changes in gall bladder

Marie

Duhan²,

Singh³

et al. 2012

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Section: 7-10mentioning

confidence: 66%

Correlation of gallstone characteristics with mucosal changes in gall bladder

Marie

Duhan²,

Singh³

et al. 2012

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“…We observed pyloric metaplasia predominance in both of our study groups with 23 (5.3%) cases in Group 1 and 38 (8.8%) cases in Group 2, similar to the literature. Metaplastic epithelium is more susceptible to malignant transformation than the normal epithelium [9]. We determined low grade dysplasia in two (0.5%) cases, and there was no increase in the prevalence of this lesion with the increased sample size.…”

Section: Discussionmentioning

confidence: 99%

Do histopathologic findings improve by increasing the sample size in cholecystectomies?

Özgür

Toprak

Koyuncuer³

et al. 2013

World J Surg Onc

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BackgroundGallbladder diseases present with cholelithiasis in a wide spectrum of adenomas and cancers. Two or three specimens are sampled in cholecystectomies in routine pathology practice. The aim of this study was to investigate the increase in frequency of histologic alterations in cholecystectomies, particularly precancerous lesions, by increasing the sample size to understand the carcinoma pathway.MethodsCholecystectomies of 432 patients with pathology records and materials from two medical centers were collected, and two groups were created. Initial data with two or three samples were allocated to Group 1 and the new six samples with the initial ones were allocated to Group 2. Hematoxylin and eosin (H&E) sections were examined for histopathologic alterations, and periodic acid–Schiff (PAS) Alcian blue (pH 2.5) and high iron diamine (pH 2.5) stains were used to signify the mucin profile in case of metaplasias. For the comparison of findings, non-parametric tests, McNemar’s tests, chi-squared tests and Fisher’s exact test were performed.ResultsOf the 432 patients, 308 (71.3%) patients were female and 124 (28.7%) patients were male. The mean age of patients was 47.9 ± 14.6 years. Cholesterolosis was observed in 95 (22%) patients in Group 1 and 108 (25%) patients in Group 2. Gallstones were detected in 255 (59%) of the cholecystectomies. There was a significant difference between Group 1 and Group 2 by increasing the sample size when we compared cholesterolosis, metaplasia and polyps (P <0.05). Cholecystitis and dysplasia rates were the same in both of the groups. There was no cancer determined.ConclusionIncreasing the sample size in cholecystectomies increased the diagnosis of some histologic alterations, but further studies with a larger number of samples over a longer period time might increase the ability to determine precancerous lesions and concomitants.

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“…in this model of carcinogenesis, mucosal damage caused by a stone and subsequent chronic inflammation is thought to be important in the histogenesis of intestinal metaplasia and dysplasia (30) and GB carcinoma as well (31,32). although the exact relationship between intestinal differentiation and carcinoma is unknown, it is well known that metaplastic epithelium is more susceptible to malignant transformation than the normal one (4,33). it is suggested that cholelithiasis induces the appearance of a stem endodermal cell that, in turn, may differentiate into cells with mature intestinal or gastric phenotypes (34).…”

Section: Discussionmentioning

confidence: 99%

Expression of p16 protein and cyclin d1 in periampullary carcinomas

Tuncer¹,

Türk²,

Arici³

et al. 2011

TJPATH

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Objective: Gallbladder is one of the most commonly encountered specimen in a pathology laboratory. a diverse spectrum of diseases affect the biliary system, often presenting with similar clinical signs and symptoms. We aimed to define the profile of gallbladder diseases in our region, and to determine potential correlations between histopathologic features we observed. Material and Method:We reviewed all cholecystectomies processed in Department of Pathology of afyon Kocatepe University Hospital between January 2000 and March 2008. Gross and histopathologic features of the specimens were reevaluated.Results: among 1500 patients; 69.9% were women and 30.1% were men. We found out fourteen primary gallbladder carcinomas (0.93%) with adenocarcinomas being the most frequent type (78.57%). The rate of cholelithiasis was found as 89.9%. The most common type of gallstones was mixed cholesterol type gallstones with 67.5% followed by black pigment and brown pigment types as 23.83% and 5.89%, respectively. The association of metaplasia with dysplasia and also gallstones were statistically significant (p<0.001, p<0.005). The rate of the gallbladder polyps was 2.6% with the cholesterol polyps being the most common type (56.4%). Conclusion:Gallbladder diseases often present with similar clinical signs and symptoms and a surgical pathologist should be alert especially of precancerous lesions. With our results, we also conclude that elderly women with longstanding gallstone disease should undergo elective surgery even when no symptoms are present.

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Precancerous lesions of the gallbladder mucosa.

Cited by 14 publications

References 4 publications

Correlation of gallstone characteristics with mucosal changes in gall bladder

Correlation of gallstone characteristics with mucosal changes in gall bladder

Do histopathologic findings improve by increasing the sample size in cholecystectomies?

Expression of p16 protein and cyclin d1 in periampullary carcinomas

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