Prebiotics supplementation: an effective approach to mitigate the detrimental effects of heat stress in broiler chickens

Awad, Elmutaz Atta; Zulkifli, I.; Ramiah, Suriya Kumari; Khalil, Eilaf Suliman; Abdallh, Medani Eldow

doi:10.1080/00439339.2020.1759222

Cited by 14 publications

(12 citation statements)

References 77 publications

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“…Interestingly, we found that dietary SDP supplementation attenuated HS-induced histological damage. Similarly, the existing literature reveals that the use of dietary phytochemicals can improve the morphology of immune organs of animals exposed to HS [10,34]. Previous studies have demonstrated that dietary algae (EP) polysaccharides can alleviate histopathological alterations of immune organs in a stressed animal model [21,24].…”

Section: Discussionmentioning

confidence: 93%

Seaweed-Derived Polysaccharides Attenuate Heat Stress-Induced Splenic Oxidative Stress and Inflammatory Response via Regulating Nrf2 and NF-κB Signaling Pathways

Zhuang

Zhao

et al. 2022

Marine Drugs

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With global warming, heat stress (HS) has become a worldwide concern in both humans and animals. The ameliorative effect of seaweed (Enteromorpha prolifera) derived polysaccharides (SDP) on HS-induced oxidative stress and the inflammatory response of an immune organ (spleen) was evaluated using an animal model (Gallus gallus domesticus). In total, 144 animals were used in this 4-week trial and randomly assigned to the following three groups: thermoneutral zone, HS, and HS group supplemented with 1000 mg/kg SDP. Dietary SDP improved the antioxidant capacity and reduced the malondialdehyde (MDA) of the spleen when exposed to HS, regulated via enhancing nuclear factor erythroid 2-related factor-2 (Nrf2) signaling. Furthermore, the inclusion of SDP reduced the levels of pro-inflammatory cytokines and alleviated HS-induced splenic inflammatory response by suppressing the nuclear factor-kappa B (NF-κB) p65 signaling. These findings suggest that the SDP from E. prolifera can be used as a functional food and/or feed supplement to attenuate HS-induced oxidative stress and inflammatory responses of the immune organs. Moreover, the results could contribute to the development of high-value marine products from seaweed for potential use in humans and animals, owing to their antioxidant and anti-inflammatory effects.

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Section: Discussionmentioning

confidence: 93%

Seaweed-Derived Polysaccharides Attenuate Heat Stress-Induced Splenic Oxidative Stress and Inflammatory Response via Regulating Nrf2 and NF-κB Signaling Pathways

Zhuang

Zhao

et al. 2022

Marine Drugs

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“…Synbiotics are synergistic combinations of prebiotics and probiotics ( Schrezenmeir and de Vrese, 2001 ). Both prebiotics and probiotics exert beneficial effects on animal health when supplemented into the diet ( Sohail et al, 2012 ; Sugiharto et al, 2017 ; Awad et al, 2021 ). However, their combination as synbiotics may lead to synergistic and additive effects.…”

Section: Alleviating the Adverse Effects Of Heat Stressmentioning

confidence: 99%

The Microbiota-Gut-Brain Axis During Heat Stress in Chickens: A Review

et al. 2021

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Heat stress is a global issue for the poultry industries with substantial annual economic losses and threats to bird health and welfare. When chickens are exposed to high ambient temperatures, like other species they undergo multiple physiological alterations, including behavioral changes, such as cessation of feeding, initiation of a stress signaling cascade, and intestinal immune, and inflammatory responses. The brain and gut are connected and participate in bidirectional communication via the nervous and humoral systems, this network collectively known as the gut-brain axis. Moreover, heat stress not only induces hyperthermia and oxidative stress at the gut epithelium, leading to impaired permeability and then susceptibility to infection and inflammation, but also alters the composition and abundance of the microbiome. The gut microflora, primarily via bacterially derived metabolites and hormones and neurotransmitters, also communicate via similar pathways to regulate host metabolic homeostasis, health, and behavior. Thus, it stands to reason that reshaping the composition of the gut microbiota will impact intestinal health and modulate host brain circuits via multiple reinforcing and complementary mechanisms. In this review, we describe the structure and function of the microbiota-gut-brain axis, with an emphasis on physiological changes that occur in heat-stressed poultry.

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“…Therefore, poultry is very susceptible to heat stress compared to other farm animals, and commercial broilers produce more metabolic heat than other local pure genotypes of broilers. In terms of mechanism, heat stress easily damages the antioxidant system, alters intestinal microbiota [ 4 ], and disrupts the intestinal function [ 6 ] of the poultry [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Ellagic Acid Improves Antioxidant Capacity and Intestinal Barrier Function of Heat-Stressed Broilers via Regulating Gut Microbiota

Yang

Liu

Wang

et al. 2022

Animals

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Heat stress (HS) has been revealed to damage the antioxidant system and intestinal barrier function, which greatly threatens poultry production. The present study investigated the effects of dietary ellagic acid (EA) on the antioxidant system, gut barrier function, and gut microbiota of heat-stressed broilers. Arbor Acres 14-day-old broilers numbering 360 were randomly divided into six groups, including one negative control group (NC) and five experimental groups. The broilers in the NC group were supplemented with a basal diet at a normal temperature (23 ± 2 °C). The broilers in the experimental groups were supplemented with basal diets containing EA at different doses (0, 75, 150, 300, and 600 mg/kg) at HS temperature (35 ± 2 °C). The experiment lasted for 4 weeks. Results showed that dietary EA reduced the corticosterone (CORT), LPS, and diamine oxidase (DAO) levels in the serum of heat-stressed broilers. Additionally, dietary EA improved the antioxidant enzyme activity and mRNA levels of Nrf2/HO-1 in the ileum of heat-stressed broilers. The relative abundances of Streptococcus, Ruminococcus_torques, Rothia, Neisseria, Actinomyces, and Lautropia in the cecum were significantly reduced by the EA supplementation in a dose-dependent manner. Notably, the LPS, DAO, and MDA in the serum were revealed to be positively correlated with the relative abundances of Rothia, Neisseria, Actinomyces, and Lautropia, while the GSH-px, SOD, and CAT levels in the serum were negatively correlated with the relative abundances of Ruminococcus_torques, Rothia, Neisseria, Actinomyces, Streptococcus, and Lautropia. Taken together, dietary EA improved the antioxidant capacity, intestinal barrier function, and alleviated heat-stressed injuries probably via regulating gut microbiota.

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Prebiotics supplementation: an effective approach to mitigate the detrimental effects of heat stress in broiler chickens

Cited by 14 publications

References 77 publications

Seaweed-Derived Polysaccharides Attenuate Heat Stress-Induced Splenic Oxidative Stress and Inflammatory Response via Regulating Nrf2 and NF-κB Signaling Pathways

Seaweed-Derived Polysaccharides Attenuate Heat Stress-Induced Splenic Oxidative Stress and Inflammatory Response via Regulating Nrf2 and NF-κB Signaling Pathways

The Microbiota-Gut-Brain Axis During Heat Stress in Chickens: A Review

Ellagic Acid Improves Antioxidant Capacity and Intestinal Barrier Function of Heat-Stressed Broilers via Regulating Gut Microbiota

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