Prebiotic Supplementation in Kidney Transplant Recipients for Preventing Infections and Gastrointestinal Upset: A Randomized Controlled Feasibility Study

Chan, Samuel; Hawley, Carmel M.; Pascoe, Elaine M.; Cao, Christopher; Campbell, Scott; Campbell, Katrina L.; Francis, Ross; Hale, Rachael; Isbel, Nicole M.; Morrison, Mark; Johnson, David W.

doi:10.1053/j.jrn.2022.02.006

Cited by 8 publications

(6 citation statements)

References 22 publications

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“…Subjects assigned to the intervention group had lower microbial richness and Shannon diversity (a combined measure of microbial richness and evenness) scores at baseline when compared to subjects assigned to placebo (Figure 2). However, after 6 to 8 weeks of prebiotic supplementation, significant increases in microbial richness (from 96 ± 46.5 to 142 ± 38.6, p = .01) and Shannon Diversity (from 4 In that context, we propose there are three key observations arising from the findings reported here. First, our findings suggest that there can be a significant improvement in the microbial diversity following prebiotic supplementation in acute kidney transplant patients.…”

Section: Characteristics Of the Gastrointestinal Microbiota Following...mentioning

confidence: 50%

“…The study protocol details and metagenomics sequencing have been published. 3,4 The study flow diagram and the baseline characteristics of the intervention (n = 25) and control (n = 24) arm are illustrated in Figure 1A and Table 1, respectively. Subjects in both groups received standard immunosuppression (tacrolimus, mycophenolate mofetil, prednisolone) as well as basiliximab induction and prophylactic antimicrobial use.…”

Section: Characteristics Of the Gastrointestinal Microbiota Following...mentioning

confidence: 99%

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Characteristics of the gastrointestinal microbiota following prebiotic supplementation in acute kidney transplant recipients: Results from a randomised controlled trial

Chan,

Wood,

Hawley

et al. 2023

Clinical Transplantation

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Section: Characteristics Of the Gastrointestinal Microbiota Following...mentioning

confidence: 50%

Section: Characteristics Of the Gastrointestinal Microbiota Following...mentioning

confidence: 99%

Characteristics of the gastrointestinal microbiota following prebiotic supplementation in acute kidney transplant recipients: Results from a randomised controlled trial

Chan,

Wood,

Hawley

et al. 2023

Clinical Transplantation

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“…P-cresol generally accumulates when its production by the dysbiotic gut microbiome increases ( Guida et al., 2017 ). In a study, 27 recipients of kidney transplantation with gastrointestinal symptoms received a prebiotic powder suspension with breakfast for 7 weeks ( Chan et al., 2022 ). In this randomized placebo-controlled trial, prebiotics significantly suppressed gastrointestinal symptoms.…”

Section: Kidney Transplantation and Regulation Of Gut Microbiotamentioning

confidence: 99%

“…Norovirus has been attributed to approximately 25% of cases with diarrhea after transplantation. Clostridium difficile infection occurs in 2%–7% of kidney transplant recipients ( Chan et al., 2022 ). Evidence from several studies has suggested that C. difficile also causes nosocomial infections that patients contract within the first few months after transplantation ( Guida et al., 2017 ; Lin et al., 2018 ).…”

Section: Kidney Transplantation Outcomes and Profiles Of Gut Microbiotamentioning

confidence: 99%

Regulation of gut microbiota: a novel pretreatment for complications in patients who have undergone kidney transplantation

Yao

et al. 2023

Front. Cell. Infect. Microbiol.

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Kidney transplantation is an effective method to improve the condition of patients with end-stage renal disease. The gut microbiota significantly affects the immune system and can be used as an influencing factor to change the prognoses of patients who have undergone kidney transplantation. Recipients after kidney transplantation showed a lower abundance of Firmicutes and Faecalibacterium prausnitzii and a higher proportion of Bacteroidetes and Proteobacteria. After using prebiotics, synbiotics, and fecal microbiota transplantation to regulate the microbial community, the prognoses of patients who underwent kidney transplantation evidently improved. We aimed to determine the relationship between gut microbiota and various postoperative complications inpatients who have undergone kidney transplantation in recent years and to explore how gut microecology affects post-transplant complications. An in-depth understanding of the specific functions of gut microbiota and identification of the actual pathogenic flora during complications in patients undergoing kidney transplantation can help physicians develop strategies to restore the normal intestinal microbiome of transplant patients to maximize their survival and improve their quality of life.

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“…2010]. W jednym z najnowszych badań nad wpływem prebiotyków zaobserwowano mniejsze nasilenie objawów żołądkowo-jelitowych w stosunku do pacjentów przyjmujących placebo [Chan i in. 2022].…”

Section: Pozytywny Wpływ Wykorzystania Prebiotyków U Chorych Po Przes...unclassified

Wybrane zagadnienia z zakresu bromatologii, t. 3

2023

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Berberine in the treatment of type 2 diabetes -a review Cukrzyca typu 2 (ang. diabetes mellitus type 2, T2DM) jest rozpowszechniona w społeczeństwie. Według raportu Narodowego Funduszu Zdrowia w 2018 r. w Polsce na cukrzycę chorowało 2,9 mln dorosłych, co stanowiło 9,1% populacji, przy czym diagnoza częściej dotyczyła kobiet [Narodowy Fundusz Zdrowia 2019]. W raporcie zwrócono uwagę na trend wzrostowy chorobowości w latach 2013-2018. Cukrzyca jest też chorobą śmiertelną, na co uwagę zwraca Główny Urząd Statystyczny [2017] -w 2016 r. odnotowano ponad 8 tysięcy zgonów z jej powodu. Chociaż na T2DM przeznacza się obecnie 10% globalnych wydatków na zdrowie, pozostaje ona w pierwszej czwórce przyczyn zgonów z powodu chorób niezakaźnych [Balakumar i in. 2016]. Berberyna jest alkaloidem izochinolinowym, należącym do klasy protoberberyn. Tyrozyna lub fenyloalanina są prekursorami jej biosyntezy [Singh i Sharma 2018], a wzór chemiczny to C20H18NO4 + [National Center for Biotechnology Information 2023]. W przypadku doustnej drogi podania biodostępność jest bardzo niska. Około 56% spożytej berberyny nie wchłania się w przewodzie pokarmowym, a 43,5% jest wydalane w wyniku metabolizmu w jelicie cienkim i wątrobie, przez co mniej niż 0,5% dostaje się do krążenia [Liu i in. 2016]. Mimo niskiej przyswajalności po podaniu w formie doustnej dowiedziono, że dodanie witaminy E lub ekstraktu z Quillaia (E999) zwiększa osiągane maksymalne stężenie we krwi [Yagiz i in. 2022]. Berberyna występuje w różnych roślinach, w tym w: Annonaceae, Menispermaceae, Berberidaceae, Papaveraceae, Rutaceae i Ranunculaceae [Bahar i in. 2011]. Głównym jej źródłem jest berberys, który powszechnie występuje w stanie dzikim w Europie [Činčura i in. 1990]. Szerokie rozpowszechnienie roślin zawierających berberynę spowodowało częste jej wykorzystanie w medycynie ludowej wielu kultur.Celem pracy jest zwrócenie uwagi na problem zdrowotny, jakim jest cukrzyca, i wskazanie możliwości terapii wspomnianej choroby również poprzez wprowadzenie do diety (np. w formie suplementów) berberyny -naturalnie występującej substancji.

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Prebiotic Supplementation in Kidney Transplant Recipients for Preventing Infections and Gastrointestinal Upset: A Randomized Controlled Feasibility Study

Cited by 8 publications

References 22 publications

Characteristics of the gastrointestinal microbiota following prebiotic supplementation in acute kidney transplant recipients: Results from a randomised controlled trial

Characteristics of the gastrointestinal microbiota following prebiotic supplementation in acute kidney transplant recipients: Results from a randomised controlled trial

Regulation of gut microbiota: a novel pretreatment for complications in patients who have undergone kidney transplantation

Wybrane zagadnienia z zakresu bromatologii, t. 3

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