Prebiotic effects of plant-derived (poly)phenols on host metabolism: Is there a role for short-chain fatty acids?

Freitas, Perla Lopes de; Barros, Marcus Vinicius Câmara; Fróes, Rômulo Brênno Lopes; França, Lucas Martins; Paes, Antonio Marcus de Andrade

doi:10.1080/10408398.2022.2100315

Cited by 3 publications

(2 citation statements)

References 86 publications

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“…Numerous studies have shown that plant polyphenols are able to influence the levels of SCFAs in the intestine and feces, such as capsaicin and quercetin (Freitas et al, 2022). Here, we found that EGCG administration changed the structure and abundance of gut microbiota to reduce the rise of total SCFAs in the gut of HFD-induced obese mice.…”

Section: Discussionmentioning

confidence: 50%

“…It has been shown that an increase in the ratio of Firmicutes and Bacteroides, the two main SCFA‐producing microbial phyla in the HFD mice model, affects the concentration and ratio of acetic, propionic, and butyric acids in the gut; for example, HFD‐induced obese mice may have significantly elevated levels of acetic acid in the body due to metabolic disturbances (Perry et al., 2016). Numerous studies have shown that plant polyphenols are able to influence the levels of SCFAs in the intestine and feces, such as capsaicin and quercetin (Freitas et al., 2022). Here, we found that EGCG administration changed the structure and abundance of gut microbiota to reduce the rise of total SCFAs in the gut of HFD‐induced obese mice.…”

Section: Discussionmentioning

confidence: 99%

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Green tea catechin epigallocatechin gallate alleviates high‐fat diet‐induced obesity in mice by regulating the gut–brain axis

et al. 2023

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Plant polyphenols have gained attention in recent years because of their potential to alleviate obesity and metabolic syndrome, protect neurological function, and maintain intestinal function. Here, we evaluated the effect of green tea catechin epigallocatechin gallate (EGCG) to suppress obesity, alleviate intestinal inflammation, and regulate hypothalamic neurotransmitters in high‐fat diet mice. Obese male C57BL/6J mice were gavaged with 25, 50, or 100 mg/kg·body weight (bw) of EGCG or water per day for 6 weeks. The results demonstrated that EGCG significantly reduced bw, fat accumulation, and liver steatosis. EGCG also modulated hypothalamic neurotransmitters such as dopamine and 5‐HTP. Besides, EGCG attenuated the expression of colonic inflammatory factors and barrier damage, increased the gut microbial abundance such as genus Alloprevotella, reduced short‐chain fatty acids, and downregulated the transcription factors. The results suggest that EGCG may alleviate obesity and related metabolic disorders through gut–brain interaction.

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Section: Discussionmentioning

confidence: 50%

Section: Discussionmentioning

confidence: 99%

Green tea catechin epigallocatechin gallate alleviates high‐fat diet‐induced obesity in mice by regulating the gut–brain axis

et al. 2023

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Eugenia uniflora (pitanga) juice as a new alternative vehicle for Limosilactobacillus fermentum ATCC 23271: evaluation of antioxidant and anti-infective effects

Costa dos Santos,

da Silva Pereira,

da Silva

et al. 2024

Braz J Microbiol

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Plant-Derived (Poly)phenols and Their Metabolic Outcomes: The Pursuit of a Role for the Gut Microbiota

et al. 2022

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Plant-derived (poly)phenolic compounds have been undoubtedly shown to promote endocrine homeostasis through the improvement of diverse metabolic outcomes. Amongst diverse potential mechanisms, the prebiotic modulatory effects exerted by these compounds on the gut microbiota have supported their nutraceutical application in both experimental and clinical approaches. However, the comprehension of the microbiota modulatory patterns observed upon (poly)phenol-based dietary interventions is still in its infancy, which makes the standardization of the metabolic outcomes in response to a given (poly)phenol a herculean task. Thus, this narrative review sought to gather up-to-date information on the relationship among (poly)phenols intake, their modulatory effect on the gut microbiota diversity, and consequent metabolic outcomes as a supportive tool for the future design of experimental approaches and even clinical trials.

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Prebiotic effects of plant-derived (poly)phenols on host metabolism: Is there a role for short-chain fatty acids?

Cited by 3 publications

References 86 publications

Green tea catechin epigallocatechin gallate alleviates high‐fat diet‐induced obesity in mice by regulating the gut–brain axis

Green tea catechin epigallocatechin gallate alleviates high‐fat diet‐induced obesity in mice by regulating the gut–brain axis

Eugenia uniflora (pitanga) juice as a new alternative vehicle for Limosilactobacillus fermentum ATCC 23271: evaluation of antioxidant and anti-infective effects

Plant-Derived (Poly)phenols and Their Metabolic Outcomes: The Pursuit of a Role for the Gut Microbiota

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