Prebiotic effects of a mixture of agavins and green banana flour in a mouse model of obesity

Alvarado-Jasso, Guadalupe Monserrat; Camacho-Díaz, Brenda Hildeliza; Arenas-Ocampo, Martha Lucía; Jiménez-Ferrer, Enrique; Mora‐Escobedo, Rosalva; Osorio-Dı́az, Perla

doi:10.1016/j.jff.2019.103685

Cited by 40 publications

(31 citation statements)

References 46 publications

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“…In the present work, we saw a reduction of GLP-1 levels in HF mice; nevertheless, this effect was reverted in the HF+A group. Increment of GLP-1 levels with the prebiotic consumption might be attributed to the increased number of L-cells (enteroendocrine cells producing GLP-1 in the jejunum and colon) as previously was reported for linear fructans [51] as well as a SCFA production derived from microbial fermentation of agavins [16,17]. In addition, levels of GLP-1 were positively associated with octadecanoic acid, ethyl ester and uracil concentrations ( Figure S3).…”

Section: Discussionsupporting

confidence: 69%

“…Nowadays, obesity is a serious worldwide public health problem that in many occasions is accompanied by metabolic alterations which include hyperglycemia and insulin resistance, among others. Previously, it was demonstrated that highly branched neo-fructans (agavins) consumption could be a very good dietary strategy to prevent or mitigate some problems associated with the metabolic syndrome derived from high-fat diet consumption [15][16][17]. However, to our knowledge, there is not an integral study evidencing the effects of agavins on gut microbiota regulation and their metabolic products as well as their impact on metabolic endotoxemia and low-grade inflammation, playing both fundamental roles on the development of the known metabolic syndrome [2,3].…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, recently, increasing interest in highly branched prebiotics has arisen from recent findings including the modulation of gut microbiota composition driven by agavins intake, particularly decreasing the Firmicutes/Bacteroidetes ratio and promoting the increased abundance of the Enterobacteriaceae family, with positive effects on body weight loss in overweight mice [15]. In addition, agavins intake also mitigate the metabolic syndrome, through the generation of metabolic products and satiety hormones such glucagon-like peptide-1 (GLP-1) and leptin [16,17].…”

Section: Introductionmentioning

confidence: 99%

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Highly Branched Neo-Fructans (Agavins) Attenuate Metabolic Endotoxemia and Low-Grade Inflammation in Association with Gut Microbiota Modulation on High-Fat Diet-Fed Mice

Huazano-García

Silva-Adame

Vázquez-Martínez

et al. 2020

Foods

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Highly branched neo-fructans (agavins) are natural prebiotics found in Agave plants, with a large capacity to mitigate the development of obesity and metabolic syndrome. Here, we investigated the impact of agavins intake on gut microbiota modulation and their metabolites as well as their effect on metabolic endotoxemia and low-grade inflammation in mice fed high-fat diet. Mice were fed with a standard diet (ST) and high-fat diet (HF) alone or plus an agavins supplement (HF+A) for ten weeks. Gut microbiota composition, fecal metabolite profiles, lipopolysaccharides (LPS), pro-inflammatory cytokines, and systemic effects were analyzed. Agavins intake induced substantial changes in gut microbiota composition, enriching Bacteroides, Parabacteroides, Prevotella, Allobaculum, and Akkermansia genus (LDA > 3.0). l-leucine, l-valine, uracil, thymine, and some fatty acids were identified as possible biomarkers for this prebiotic supplement. As novel findings, agavins supplementation significantly decreased LPS and pro-inflammatory (IL-1α, IL-1β, and TNF-α; p < 0.05) cytokines levels in portal vein. In addition, lipid droplets content in the liver and adipocytes size also decreased with agavins consumption. In conclusion, agavins supplementation mitigate metabolic endotoxemia and low-grade inflammation in association with gut microbiota regulation and their metabolic products, thus inducing beneficial responses on metabolic disorders in high-fat diet-fed mice.

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Section: Discussionsupporting

confidence: 69%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Highly Branched Neo-Fructans (Agavins) Attenuate Metabolic Endotoxemia and Low-Grade Inflammation in Association with Gut Microbiota Modulation on High-Fat Diet-Fed Mice

Huazano-García

Silva-Adame

Vázquez-Martínez

et al. 2020

Foods

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“…Although all samples could promote the growth of probiotics, BS and URB possessed the significantly highest growth promotion ability over 18-48 h. Hence, URB and BS from Kluai Namwa Luang not only exhibited the prebiotic properties but also promoted the growth of probiotics. This is consistent with previous studies reporting probiotics bacterial growth and count effects of banana powder from other banana varieties [61,62,63].…”

Section: Promoting Growth Effect Of Probiotics Of Urb Prb and Bssupporting

confidence: 93%

Physicochemical and prebiotic properties of resistant starch from Musa sapientum Linn., ABB group, cv. Kluai Namwa Luang

Jaiturong

Laosirisathian

Sirithunyalug

et al. 2020

Heliyon

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Resistant starch (RS), a current health trend, can be obtained from various natural sources. Musa sapientum Linn., ABB group, cv. Kluai Namwa Luang is a good source of RS. This is the first study to investigate the physicochemical properties, RS contents, and prebiotic properties of unpeeled raw banana powder (URB), peeled raw banana powder (PRB), and banana starch (BS) from Kluai Namwa Luang. Their physicochemical properties were characterized by scanning electron microscope, differential scanning calorimeter, and X-ray diffractometer. The RS contents were determined using the Megazyme Resistant Starch Assay Kit. The prebiotic properties are reported as a prebiotic index (PI). The particle morphology of URB, PRB, and BS granules showed a smooth surface with irregular size and shape. Their gelatinization temperatures were 74–78 °C. All samples exhibited typical B-type diffraction patterns. URB contained the highest dietary fiber (9.7 ± 0.2 g per 100 g of dried sample), whereas BS contained the highest RS content (74.1 ± 0.1 g per 100 g of dried sample). Both URB and BS possessed excellent probiotic growth promotion, prebiotic properties with PI values comparable to the commercial inulin, and were highly resistant to digestive enzymes. Therefore, BS from Kluai Namwa Luang is suggested as functional nutrient in health promotion products.

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“…Our preceding researches ( Tan and Wang, 2018 ; Wang, 2018 ) report that BRS has a good effect on weight loss and improved the condition of the obese rats. Moreover, some literatures ( Alvarado-Jasso et al, 2020 ; Wu et al, 2020 ) show that banana flour is benefit for reducing body fat. But few studies focused on the mechanistic role of the BRS-induced weight loss.…”

Section: Introductionmentioning

confidence: 99%

Effects of Banana Resistant Starch on the Biochemical Indexes and Intestinal Flora of Obese Rats Induced by a High-Fat Diet and Their Correlation Analysis

Wang

Tan

et al. 2021

Front. Bioeng. Biotechnol.

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The effects of banana resistant starch (BRS) on obesity-related metabolic and intestinal flora were investigated in a high-fat diet-induced obesity model. After 6 weeks of intervention, the glucolipid metabolism index [blood glucose (GLU), total cholesterol (TC), triacylglycerol (TG), low density lipoprotein-cholesterol (LDL-C), and high density lipoprotein-cholesterol (HDL-C)], hormone index [leptin (LEP), insulin (INS), ghrelin, adiponectin (ADP), and thyroxine (T4)], and 16S rRNA sequencing analyses were performed for each group to explore the regulating effect of intestinal flora and the mechanism of weight loss in obese rats. The results showed that (1) BRS intervention significantly reduced the levels of GLU, TG, TC, LDL-C, LEP, and INS (p < 0.01) and increased the contents of ghrelin (p < 0.05) and ADP (p < 0.01). (2) BRS could improve the diversity of intestinal flora and regulate the overall structure of intestinal microorganisms, mainly by upregulating the Bacteroides/Firmicutes ratio and the relative abundance of Cyanobacteria and downregulating the relative abundances of Deferribacteres and Tenericutes (at the phylum level). BRS could inhibit the proliferation of Turicibacter, Romboutsia, and Oligella and increase the abundances of Bacteroides, Ruminococcaceae, and Lachnospiraceae (at the genus level). (3) Some significant correlations were observed between the gut microbiota and biomarkers. Turicibacter, Romboutsia, and Oligella were positively correlated with GLU, TG, TC, LEP, and INS and negatively correlated with ghrelin and ADP. Bacteroides, Parabacteroides, and Akkermansia were negatively correlated with GLU, TG, and TC. Conclusion: BRS had promising effects on weight loss, which could be associated with the improvement in host metabolism by regulating intestinal flora.

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Prebiotic effects of a mixture of agavins and green banana flour in a mouse model of obesity

Cited by 40 publications

References 46 publications

Highly Branched Neo-Fructans (Agavins) Attenuate Metabolic Endotoxemia and Low-Grade Inflammation in Association with Gut Microbiota Modulation on High-Fat Diet-Fed Mice

Highly Branched Neo-Fructans (Agavins) Attenuate Metabolic Endotoxemia and Low-Grade Inflammation in Association with Gut Microbiota Modulation on High-Fat Diet-Fed Mice

Physicochemical and prebiotic properties of resistant starch from Musa sapientum Linn., ABB group, cv. Kluai Namwa Luang

Effects of Banana Resistant Starch on the Biochemical Indexes and Intestinal Flora of Obese Rats Induced by a High-Fat Diet and Their Correlation Analysis

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