Prebiotic Consumption Alters Microbiota but Not Biological Markers of Stress and Inflammation or Mental Health Symptoms in Healthy Adults: A Randomized, Controlled, Crossover Trial

Mysonhimer, Annemarie R; Cannavale, Corinne N.; Bailey, Melisa A; Khan, Naiman A.; Holscher, Hannah D.

doi:10.1016/j.tjnut.2023.02.015

Cited by 13 publications

(14 citation statements)

References 78 publications

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“…Consistent with these findings, a number of recent studies have shown improvements in affective symptoms following prebiotic interventions (21-26) , often accompanied by increases in Bifidobacterium (21, 23, 26) . In this study, we too observed significant increases in Bifidobacterium and Parabacteroides in the treatment group, both of which have been linked to fibre degradation and the subsequent production of SCFAs (54, 55) . It is important to note that we did not observe any between-group differences in these genera at week 12.…”

Section: Discussionmentioning

confidence: 44%

Effects of a diverse prebiotic fibre blend on inflammation, the gut microbiota, and affective symptoms: A pilot open label randomised controlled trial

Hall,

Hepsomali,

Dalile

et al. 2024

Preprint

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Emerging evidence suggests that low-grade systemic inflammation plays a key role in altering brain activity, behaviour, and affect. Modulation of the gut microbiota using prebiotic fibre offers a potential therapeutic tool to regulate inflammation, mediated via the production of short-chain fatty acids (SCFAs). However, the impact of prebiotic consumption on affective symptoms, and the possible contribution from inflammation, gut symptoms, and the gut microbiome, is currently underexamined. In this 12-week study, the effects of a diverse prebiotic blend on inflammation, gut microbiota profiles, and affective symptoms in a population with Metabolic Syndrome (MetS) was examined. Sixty patients meeting the criteria for MetS were randomised into a treatment group (n = 40), receiving 10g per day of a diverse prebiotic blend and healthy eating advice and a control group (n = 20), receiving healthy eating advice only. Our results showed a significant reduction in C-reactive protein (CRP), alongside improvements in self-reported affective scores in the treatment compared to the control group. While there were no differences in relative abundance between groups at week 12, there was a significant increase from baseline to week 12 in Bifidobacterium and Parabacteroides in the treatment group, both of which are recognised as SCFA producers. Multivariate regression analyses further revealed that changes in affective scores were positively associated with both gastrointestinal symptoms and CRP. Together, this study provides preliminary support for the use of a diverse prebiotic blend for mood, stress, and anxiety.

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Section: Discussionmentioning

confidence: 44%

Effects of a diverse prebiotic fibre blend on inflammation, the gut microbiota, and affective symptoms: A pilot open label randomised controlled trial

Hall,

Hepsomali,

Dalile

et al. 2024

Preprint

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“…Another study demonstrated that the administration of Lactobacillus plantarum DR7 for a duration of 12 weeks resulted in a decrease in stress and anxiety levels among individuals experiencing stress, with the abundance of Negativicutes increasing after DR7 supplementation [36] . In a study in which consuming prebiotics altered the microbiota of healthy adults, the prebiotics reduced Eubacteriumbrachygroup but did not signi cantly change biomarkers of stress or mental health symptoms [37] . No literature evidence has been found linking Selenomonadales to AD.…”

Section: Discussionmentioning

confidence: 96%

Association between gut microbiota and anxiety disorders: a bidirectional two-sample Mendelian randomization study

jianbing,

changhe,

jiaqi

et al. 2023

Preprint

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Background There are many articles reporting that the component of intestinal microbiota implies a link to anxiety disorders (AD), and the brain-gut axis is also a hot topic in current research. However, the specific relevance between gut microbiota and AD is uncertain. We aimed to investigate causal relationship between gut microbiota and AD by using bidirectional Mendelian randomization (MR). Methods Genetic instrumental variable (IV) for the gut microbiota were obtained from a genome-wide association study (GWAS) involving 18,340 participants. Summary data for AD were derived from the GWAS and included 158,565 cases and 300,995 controls. We applied the inverse variance weighting (IVW) method as the main analysis. To ensure the robustness of the results, we further executed weighted median method and MR-Egger regression to evaluate potential horizontal pleiotropy. Result We discovered 16 potential connections between bacterial traits and AD. Utilizing the IVW method, we identified 7 species that exhibited a direct correlation with the risk of AD: class Negativicutes, genus Eubacteriumbrachygroup, genus Coprococcus3, genus Enterorhabdus, genus Oxalobacter, genus Ruminiclostridium6, order Selenomonadales. Additionally, we found 9 species that exhibited a negative association with AD: class Methanobacteria, family Methanobacteriaceae, family Porphyromonadaceae, genus Blautia, genus Butyricicoccus, genus Erysipelotrichaceae-UCG003, genus Parasutterella, order Methanobacteriales, phylum Proteobacteria. Conclusion Our study found a causal relation between parts of the gut microbiota and AD. Further randomized controlled trials are crucial to elucidate the protective effects of probiotics on AD and their particular protection systems.

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“…Five bacterial genera positively linked to anxiety may indicate that they exacerbate anxiety, but they were less reported. In a study in which consuming prebiotics altered the microbiota of healthy adults, the prebiotics reduced Eubacteriumbrachygroup but did not significantly change biomarkers of stress or mental health symptoms [ 32 ]. In previous studies on AD cases, it has been found that individuals with AD have lower levels of Coprococcus [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

Association between gut microbiota and anxiety disorders: a bidirectional two-sample mendelian randomization study

Li,

Fan,

Wang

et al. 2024

BMC Psychiatry

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Background There are many articles reporting that the component of intestinal microbiota implies a link to anxiety disorders (AD), and the brain-gut axis is also a hot topic in current research. However, the specific relevance between gut microbiota and AD is uncertain. We aimed to investigate causal relationship between gut microbiota and AD by using bidirectional Mendelian randomization (MR). Methods Genetic instrumental variable (IV) for the gut microbiota were obtained from a genome-wide association study (GWAS) involving 18,340 participants. Summary data for AD were derived from the GWAS and included 158,565 cases and 300,995 controls. We applied the inverse variance weighted (IVW) method as the main analysis. Cochran’s Q values was computed to evaluate the heterogeneity among IVs. Sensitivity analyses including intercept of MR-Egger method and MR-PRESSO analysis were used to test the horizontal pleiotropy. Result We discovered 9 potential connections between bacterial traits on genus level and AD. Utilizing the IVW method, we identified 5 bacterial genera that exhibited a direct correlation with the risk of AD: genus Eubacteriumbrachygroup, genus Coprococcus3, genus Enterorhabdus, genus Oxalobacter, genus Ruminiclostridium6. Additionally, we found 4 bacterial genera that exhibited a negative association with AD: genus Blautia, genus Butyricicoccus, genus Erysipelotrichaceae-UCG003 and genus Parasutterella. The associations were confirmed by the sensitivity analyses. Conclusion Our study found a causal relation between parts of the gut microbiota and AD. Further randomized controlled trials are crucial to elucidate the positive effects of probiotics on AD and their particular protection systems.

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Prebiotic Consumption Alters Microbiota but Not Biological Markers of Stress and Inflammation or Mental Health Symptoms in Healthy Adults: A Randomized, Controlled, Crossover Trial

Cited by 13 publications

References 78 publications

Effects of a diverse prebiotic fibre blend on inflammation, the gut microbiota, and affective symptoms: A pilot open label randomised controlled trial

Effects of a diverse prebiotic fibre blend on inflammation, the gut microbiota, and affective symptoms: A pilot open label randomised controlled trial

Association between gut microbiota and anxiety disorders: a bidirectional two-sample Mendelian randomization study

Association between gut microbiota and anxiety disorders: a bidirectional two-sample mendelian randomization study

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