Preattentive and attentive eye movements during visual scanning of a cocaine cue: correlation with intensity of cocaine cravings

Rosse, Richard B.; Johri, Surendra K.; Kendrick, Kathie; Hess, Anemarie L.; Alim, Tanya N.; Deutsch, Stephen I.

doi:10.1176/jnp.9.1.91

Cited by 39 publications

(8 citation statements)

References 6 publications

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“…Previously, for most substance use disorders, increased LPPs were consistently reported in relation to craving ( 20 – 22 ). Craving influences drug-seeking behavior ( 18 ) and has been associated with relapse in substance use disorders ( 14 , 32 ). In a recent study of craving using LPP, increased LPP amplitudes for drug-related cues relative to non-drug-related cues were found in individuals with cocaine use disorder; however, the LPP changes were reversed from baseline to 6–month follow-up with treatment, wherein the extent of LPP reversal was correlated with decreased craving at follow-up ( 18 ).…”

Section: Discussionmentioning

confidence: 99%

Increased Attentional Bias Toward Visual Cues in Internet Gaming Disorder and Obsessive-Compulsive Disorder: An Event-Related Potential Study

Kim

Lee

et al. 2018

Front. Psychiatry

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Internet gaming disorder (IGD) is a newly identified potential addiction disorder associated with compulsive internet-game playing behavior and attentional bias toward online gaming- related cues. Attentional bias toward addiction-related cues is the core feature of addiction that is associated with craving, but the pathophysiology of attentional bias in IGD is not well-understood, such as its relationship to compulsivity. In this study, we used the electrophysiological marker of late positive potential (LPP) to compare attentional bias in IGD and obsessive compulsive disorder (OCD). Twenty patients with IGD, 20 patients with OCD, and 23 healthy control (HC) subjects viewed a series of game-related, OCD-related, and neutral pictures while their event-related potentials (ERPs) were recorded. The game-related cues included in-game screen captures of popular internet games. The OCD-related cues included pictures which provokes obsessive and compulsive symptoms of contamination/washing or checking. LPPs were calculated as the mean value of amplitudes between 350 and 750 ms at the centro-parietal (CP1, CPz, CP2) and parietal (P1, Pz, P2) electrode sites. Higher LPP amplitudes were found for game-related cues in the IGD group than in the HCs, and higher LPP amplitudes were observed in the OCD group for OCD-related cues. The IGD group did not exhibit LPP changes in response to OCD-related cues. Subjective scales demonstrated increased arousal to game-related cues and OCD-related cues in both the IGD and OCD groups compared with the HC group. Increased LPPs in response to disorder-specific cues (game-related and OCD-related) were found in both IGD and OCD groups respectively, although the groups showed overlapping arousal on subjective scales. Our results indicate that LPP is a candidate neurophysiological marker for cue-related craving in IGD.

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Section: Discussionmentioning

confidence: 99%

Increased Attentional Bias Toward Visual Cues in Internet Gaming Disorder and Obsessive-Compulsive Disorder: An Event-Related Potential Study

Kim

Lee

et al. 2018

Front. Psychiatry

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“…We are aware of only one AB study with eye tracking involving cocaine users, which yielded evidence interpreted by the authors as offering support for AB among cocaine cues (Rosse et al, 1997; Rosse, Miller, Hess, Alim, & Deutsch, 1993). Given the existence of only one published study and the reliance on qualitatively different dependent variables in eye tracking compared to reaction time tasks, we did not include the Rosse et al (1993; 1997) findings in our review of behavioral effects of AB discussed below.…”

Section: Ab As a Cognitive Marker For Cudmentioning

confidence: 98%

A critical review of the literature on attentional bias in cocaine use disorder and suggestions for future research.

Leeman

Robinson²,

Waters³

et al. 2014

Experimental and Clinical Psychopharmacology

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Cocaine use disorder (CUD) continues to be an important public health problem and novel approaches are needed to improve the effectiveness of treatments for CUD. Recently, there has been increased interest in the role of automatic cognition such as attentional bias (AB) in addictive behaviors and AB has been proposed to be a cognitive marker for addictions. Automatic cognition may be particularly relevant to CUD as there is evidence for particularly robust AB to cocaine cues and strong relationships to craving for cocaine and other illicit drugs. Further, the wide-ranging cognitive deficits (e.g., in response inhibition and working memory) evinced by many cocaine users enhance the potential importance of interventions targeting automatic cognition in this population. In the current paper, we discuss relevant addiction theories, followed by a review of studies that examined AB in CUD. We then consider the neural substrates of attentional bias including human neuroimaging, neurobiological and pharmacological studies. We conclude with a discussion of research gaps and future directions for attentional bias in CUD.

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“…Methodologies commonly used in the addiction-related attentional bias literature include the visual/dot-probe task (e.g., Field et al, 2004; Lubman et al, 2000; Mogg et al, 2003), free viewing of naturalistic images (e.g., Rosse et al, 1993, 1997; Wong et al, 2006; Volkow et al, 2006) or the completion of a secondary task while viewing naturalistic images (e.g., Luijten et al, 2011, 2012; Nickolaou et al, 2013a), and the addiction-Stroop task in which drug-related words serve as task-irrelevant input (e.g., Carpenter et al, 2006; Cox et al, 2002; Marissen et al, 2006; see Cox et al, 2006, for a meta-analysis). Studies of value-driven attention in non-clinical samples, in contrast, tend to use simple visual stimuli in tasks designed to isolate spatial-attentional competition between the target and a distractor, such as the additional singleton and visual search paradigms (e.g., Anderson et al, 2011a, 2011b, 2014; Chelazzi et al, 2014; Feldmann-Wustefeld et al, 2016; Lee and Shomstein, 2014); however, the visual/dot-probe task (e.g., Failing and Theeuwes, 2014; Muller et al, 2016; Pool et al, 2014; Stankevich and Geng, 2014; Sun et al, in press), naturalistic images (Anderson, 2015; Hickey and Peelen, 2015), free viewing methods (Anderson and Yantis, 2012; Yamamoto et al, 2013), and the Stroop task (Krebs et al, 2010, 2011) have also been employed in the study of value-driven attention.…”

Section: Comparison Of Experimental Paradigmsmentioning

confidence: 99%

What is abnormal about addiction-related attentional biases?

Anderson

2016

Drug and Alcohol Dependence

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Background: The phenotype of addiction includes prominent attentional biases for drug cues, which play a role in motivating drug-seeking behavior and contribute to relapse. In a separate line of research, arbitrary stimuli have been shown to automatically capture attention when previously associated with reward in non-clinical samples. Methods and Results: Here, I argue that these two attentional biases reflect the same cognitive process. I outline five characteristics that exemplify attentional biases for drug cues: resistant to conflicting goals, robust to extinction, linked to dorsal striatal dopamine and to biases in approach behavior, and can distinguish between individuals with and without a history of drug dependence. I then go on to describe how attentional biases for arbitrary reward-associated stimuli share all of these features, and conclude by arguing that the attentional components of addiction reflect a normal cognitive process that promotes reward-seeking behavior.

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Preattentive and attentive eye movements during visual scanning of a cocaine cue: correlation with intensity of cocaine cravings

Cited by 39 publications

References 6 publications

Increased Attentional Bias Toward Visual Cues in Internet Gaming Disorder and Obsessive-Compulsive Disorder: An Event-Related Potential Study

Increased Attentional Bias Toward Visual Cues in Internet Gaming Disorder and Obsessive-Compulsive Disorder: An Event-Related Potential Study

A critical review of the literature on attentional bias in cocaine use disorder and suggestions for future research.

What is abnormal about addiction-related attentional biases?

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