“…Furthermore, a two-way exchange may occur between the oocyte and granulosa cells and a direct action of FSH on oocytes produces compounds whose diffusion into the granulosa cells is necessary for their proliferation and maturation (Méduri et al, 2002). Other authors observed that FSH promotes an increase in follicular diameter and proliferation of granulosa cells (rats: McGee et al, 1997;mouse: Nayudu & Osborn, 1992;Cortvrindt et al, 1996Cortvrindt et al, , 1997Cortvrindt et al, , 1998bovine: Wandji et al, 1996;Saha et al, 2000;caprine: Silva et al, 2004;ovine: Cecconi et al, 1999;human: Roy & Treacy, 1993;Wright et al, 1999). In addition, FSH was found to stimulate antrum formation and steroidogenesis in granulosa cells (Nayudu & Osborn, 1992;Boland et al, 1993;Ralph et al, 1995Ralph et al, , 1996Wandji et al, 1996;Abir et al, 1997;Gutierrez et al, 2000;Wu et al, 2000;Mao et al, 2002;Mitchell et al, 2002;Kreeger et al, 2005).…”