Prealbumin May Predict Clinical Outcomes in Children with Severe Mycoplasma pneumoniae Pneumonia

Chen, Ming-Fong; Song, Chao-Min; Wang, Shibiao; Liu, Guanghua

doi:10.5812/ijp.97680

Cited by 5 publications

(3 citation statements)

References 34 publications

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“…A PA ≤144.5 mg/L was associated with BMP formation in children with MPP. PA is a negative acute phase protein synthesized by the liver and is a non-specific host defense [15]. In addition, it was found that earlier use of corticosteroid (CS) therapy can reduce the formation of BMP in children with MPP.…”

Section: Discussionmentioning

confidence: 99%

Prediction of risk factors of bronchial mucus plugs in children with Mycoplasma pneumoniae pneumonia

Zhang

Wang

et al. 2021

Preprint

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Background: Recently, many cases of pneumonia in children with Mycoplasma pneumoniae infection have been shown to have varying degrees of intrabronchial mucus plug formation. The clinical, laboratory, radiological characteristics, and treatment of patients with Mycoplasma infection are analyzed in this study. The risk factors for M. pneumoniae pneumonia (MPP) mucus plug formation in children are explored, and a risk factor scoring system is established.Methods: MPP patients treated with bronchoscopy were retrospectively enrolled in the study from February 2015 to December 2019. The children were divided into a mucus plug group and a control group according to the presence or absence of mucus plug formation. The clinical, laboratory, radiological characteristics, and treatment of the two groups of children were compared. Univariate and multivariate logistic regression models were used to identify the risk factors for MPP mucus plug formation. The receiver operating characteristic (ROC) curve was drawn to evaluate the regression model and establish the MPP mucous plug risk factor scoring system.Results: A univariate analysis showed that the children in the mucous group were older and had a longer fever duration, longer hospital stay, higher fever peak, more cases of wheezing symptoms and allergies, and azithromycin or corticosteroids were administered later. In addition, neutrophil, C-reactive protein (CRP), lactate dehydrogenase (LDH), D-dimer (DD), sputum MP-DNA copy number, and total immunoglobulin A (IgA) levels were higher, while prealbumin (PA) levels were lower. The ROC curve analysis showed that children with MPP had PA ≤144.5 mg/L, had used corticosteroids during the course of the illness of ≥4.5 days, CRP ≥12.27 mg/L, an LDH≥462.65 U/L, and there was a possibility of intra-airway mucus formation. The independent risk factors were scored according to their odds ratio (OR) value. Among the 255 children with MPP, the high-risk group had 44 (83.02%) mucus plugs out of 53; the middle-risk group had 35 (34.3%) mucus plugs out of 102; and the low-risk group had 11 (11%) mucus plugs out of 100.Conclusions: PA levels, timing of corticosteroid use (use in the first few days), CRP levels, and LDH levels were independent risk factors for MPP mucus plug formation. This provides a basis for the early identification of MPP in children combined with mucus plug formation.

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Section: Discussionmentioning

confidence: 99%

Prediction of risk factors of bronchial mucus plugs in children with Mycoplasma pneumoniae pneumonia

Zhang

Wang

et al. 2021

Preprint

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“…Wang et al compared Mycoplasma pneumoniae (MP)-associated PB cases with an MP-associated non-PB patient group and reported higher CRP and erythrocyte sedimentation rate levels in the patient group. 9 The authors suggested that this could be used as an indicator of airway mucus embolism in children with MP. In support of this hypothesis, we thought that in our study, an increase in acute phase reactants due to viral infections may lead to airway rigid mucus plugs by increasing inflammation and edema formation.…”

Section: Discussionmentioning

confidence: 99%

Plastic Bronchitis and Human Bocavirus: A Report of Three Cases

Yılmaz

Çopur

Parlatan

et al. 2023

J Pediatr Infect Dis

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This study aims to investigate and analyze the clinical features of coexisting human bocavirus (HBoV) positivity and plastic bronchitis (PB). We present three cases with no known history of cardiac surgery who presented with cough, progressive dyspnea, and atelectasis. They tested positive for HBoV in a real-time polymerase chain reaction of both nasal lavage fluids. They were diagnosed with PB as a result of bronchoscopy and pathology. PB is a rare disease characterized by forming thick rigid casts in the tracheobronchial tree, which can progress to respiratory failure. While asthma or atopy-related type 1 PB was observed in one patient, two patients were diagnosed with PB, which was thought to have developed secondary to viral infections of unknown etiology. As far as we know, HBoV-associated PB cases are rare in the literature. Besides the commonly known infectious agents, we identified a relationship with HBoV in all the presented cases.

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“…Combined with CRP, PA can effectively improve the diagnostic e ciency of children's CAP and assess the severity of pneumonia [17]. Research by Wang et al showed that the PA level can re ect the severity of severe MPP, suggesting that the PA level may become an objective indicator for predicting the progress of severe MPP [18].…”

Section: Discussionmentioning

confidence: 99%

Prediction of risk factors of bronchial mucus plugs in children with Mycoplasma pneumoniae pneumonia

zhang

Wang

et al. 2020

Preprint

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Background Recently, many cases of pneumonia with Mycoplasma pneumoniae (M. pneumoniae) infection have been shown to have varying degrees of intrabronchial mucus plug formation. The clinical, laboratory, radiological characteristics, and treatment of patients with Mycoplasma infection are analyzed in this study. The risk factors for M. pneumoniae pneumonia (MPP) mucus plug formation are explored, and a risk factor scoring system is established. Methods MPP patients treated with bronchoscopy were retrospectively enrolled in the study from February 2015 to December 2019. The children were divided into a mucus plug group and a control group according to the presence or absence of mucus plug formation. The clinical, laboratory, radiological characteristics, and treatment of the two groups of children were compared. The receiver operating characteristic (ROC) curve was drawn to evaluate the regression model and establish the MPP mucous plug risk factor scoring system. Results A univariate analysis showed that the children in the mucous group were older and had a longer fever duration, longer hospital stay, higher fever peak, more cases of wheezing symptoms and allergies, and azithromycin or corticosteroids were administered later. In addition, neutrophil, C-reactive protein (CRP), lactate dehydrogenase (LDH), D-dimer (DD), sputum MP-DNA copy number, and total immunoglobulin A (IgA) levels were higher, while prealbumin (PA) levels were lower. The ROC curve analysis showed that children with MPP had PA ≤ 144.5 mg/L, had used corticosteroids during the course of the illness of ≥ 4.5 days, CRP ≥ 12.27 mg/L, an LDH ≥ 462.65 U/L, and there was a possibility of intra-airway mucus formation. The independent risk factors were scored according to their odds ratio (OR) value. Among the 255 children with MPP, the high-risk group had 44 (83.02%) mucus plugs out of 53; the middle-risk group had 35 (34.3%) mucus plugs out of 102; and the low-risk group had 11 (11%) mucus plugs out of 100. Conclusions PA levels, timing of corticosteroid use (use in the first few days), CRP levels, and LDH levels were independent risk factors for MPP mucus plug formation. This provides a basis for the early identification of MPP combined with mucus plug formation.

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Prealbumin May Predict Clinical Outcomes in Children with Severe Mycoplasma pneumoniae Pneumonia

Cited by 5 publications

References 34 publications

Prediction of risk factors of bronchial mucus plugs in children with Mycoplasma pneumoniae pneumonia

Prediction of risk factors of bronchial mucus plugs in children with Mycoplasma pneumoniae pneumonia

Plastic Bronchitis and Human Bocavirus: A Report of Three Cases

Prediction of risk factors of bronchial mucus plugs in children with Mycoplasma pneumoniae pneumonia

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