Prealbumin is best for nutritional monitoring

Kuszajewski, Michele L.; Clontz, Amy

doi:10.1097/00152193-200505000-00056

Cited by 31 publications

(26 citation statements)

References 1 publication

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“…21,[31][32] Synthesized by the liver and choroids plexus of the brain, it is used as a marker for denutrition. 33 Several physiological posttranslational modifications have been identified for this protein, mainly sulfonation, cysteinylation, conjugation with glutathion or cysteinyl glycine and amino acid substitution. 21,23,24,34 Here, in all patients, the distribution of different physiologically forms of TTR was modified: the sulfite form was up-regulated, contrary to the unmodified and cysteinylated forms that were down regulated in controls.…”

Section: Discussionmentioning

confidence: 99%

Discovery and Identification of Potential Biomarkers in a Prospective Study of Chronic Lymphoid Malignancies Using SELDI-TOF−MS

Miguet¹,

Bogumil²,

Decloquement³

et al. 2006

J. Proteome Res.

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The accurate diagnosis of the different forms of chronic mature B-cell lymphocytic malignancies is of primary importance to determine an appropriate and efficient treatment. Usually, the diagnosis is achieved by morphology and immunophenotyping. Nevertheless, the diagnostic tools available are not able to discriminate pathologies with variable evolution, or to classify some of them. To discover new biomarkers, we used peptide and protein profiling SELDI-TOF-MS, to analyze 39 chronic B-cell malignancies and 20 control serum samples. Markers of interest were subsequently identified and characterized. In the obtained SELDI-MS profiles, most of the differences were observed in three mass ranges (m/z = 13 000; m/z = 9000; m/z < 2000). Identification of these biomarkers was achieved either by direct enrichment on the ProteinChip arrays followed by on-chip-MS/MS or by chromatographic fractionation, 1D-gel followed by nanoLC-MS/MS analysis. An increase of a sulfite form of transthyretin (13,841 Da) was observed in the patient group. A second set of markers at 8.6 and 8.9 kDa was identified as complement related fragment proteins, the C3a and C4a anaphylatoxins. In the low mass range, several peptides originating from N-terminal and C-terminal processing of the C3 alpha and C4 alpha chains were specifically observed in 38% of the patient sera, but in none of the control sera. This study emphasizes the usefulness of mass spectrometry studies in such malignancies.

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Section: Discussionmentioning

confidence: 99%

Discovery and Identification of Potential Biomarkers in a Prospective Study of Chronic Lymphoid Malignancies Using SELDI-TOF−MS

Miguet¹,

Bogumil²,

Decloquement³

et al. 2006

J. Proteome Res.

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“…Transthyretin, also known as prealbumin, is mainly synthesized by the hepatocyte and less likely caused by hepatic disease compared to other serum proteins [1, 2]. Transthyretin has a relatively short half-life with a high percentage of essential amino acids [3].…”

Section: Introductionmentioning

confidence: 99%

Prognostic Value of Pretreatment Serum Transthyretin Level in Patients with Gastrointestinal Cancers

et al. 2019

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Background. Many studies have shown the link between the pretreatment serum transthyretin and prognosis in gastrointestinal (GI) cancers. However, based on the conclusion, the initial findings were inconsistent. Hence, this meta-analysis was performed to identify the prognostic values of the pretreatment serum transthyretin in GI cancers. Methods. Previous studies published before November 2018 were collected from a comprehensive literature search of several databases. The pooled hazard ratios (HRs) and 95% confidence intervals (CIs) were applied in the assessment of the intensity of associations. Also, the publication bias and the robustness of merged data were assessed. All statistical analyses were undertaken using STATA/SE 14.1. Results. The combined data indicated that the pretreatment serum transthyretin level was related to the prognosis in GI cancers. The group with reduced pretreatment transthyretin had a significantly worse overall survival (OS) (HR=1.71, 95% CI: 1.37-2.05). The subgroup analysis for OS further showed the predictive value of transthyretin. In addition, the low serum transthyretin level could be an unfavorable factor for recurrence-free survival (RFS) or progression-free survival (PFS) (HR=1.66, 95% CI: 1.14-2.18) in GI cancers. Conclusion. The low pretreatment serum transthyretin level implies an unfavorable prognosis for patients with GI cancers. The monitoring of pretreatment transthyretin level could contribute to the risk stratification and individualized therapy in GI cancers.

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“…Studies have suggested that the concentration of PA is sensitive and specific for the diagnosis of patients with liver cell damage [8] , [9] . In addition, it has also been widely accepted that PA, which is more sensitive than serum albumin, can be a useful indicator in assessing nutritional status and monitoring the effect of nutritional support [10] , [11] , [12] , [13] .…”

Section: Introductionmentioning

confidence: 99%

The Value of Serum Prealbumin in the Diagnosis and Therapeutic Response of Tuberculosis: A Retrospective Study

et al. 2013

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ObjectiveThe aim of this study was to examine serum prealbumin (PA) levels in patients with tuberculosis and lung cancer, and to evaluate the correlations of serum PA levels with clinicopathological characteristics.MethodTotal 760 patients were included in the study: 320 patients with tuberculosis, 320 patients with lung cancer, and 120 healthy subjects. Serum PA was detected using a biochemical analyzer to determine the value of serum PA in the diagnosis and therapeutic response of tuberculosis.ResultsCompared to lung cancer and healthy individuals, TB patients were more frequent in suffering from low serum PA (75.0% vs.30.9% vs.6.7%,P<0.01), and the serum PA levels of TB patients were significantly reduced (137.5±42.4 mg/L vs. 183.5±49.1 mg/L vs. 240.0±43.9 mg/L, P<0.01). Among various clinical characteristics, type (with pleuritis), age (≥60), ESR (>20 mm/h) and smoking status (≥20 pack×years) were associated with low serum PA levels of TB patients, while ECOG performance status (≥2) was associated with low serum PA levels of lung cancer patients. The change of serum PA levels was in accordance with the therapeutic effects of anti-TB drugs, which might present a valuable and objective indicator for monitoring the therapeutic effects of TB drugs on TB patients.ConclusionLow serum prealbumin levels are very common in TB patients and can be served as a potential indicator for differential diagnosis of lung cancer and monitoring the therapeutic effects of TB drugs.

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Prealbumin is best for nutritional monitoring

Cited by 31 publications

References 1 publication

Discovery and Identification of Potential Biomarkers in a Prospective Study of Chronic Lymphoid Malignancies Using SELDI-TOF−MS

Discovery and Identification of Potential Biomarkers in a Prospective Study of Chronic Lymphoid Malignancies Using SELDI-TOF−MS

Prognostic Value of Pretreatment Serum Transthyretin Level in Patients with Gastrointestinal Cancers

The Value of Serum Prealbumin in the Diagnosis and Therapeutic Response of Tuberculosis: A Retrospective Study

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