Prealbumin as a nutrition status indicator may be associated with outcomes of geriatric hip fractures: a propensity score matching and 1-year follow-up study

Liu, Mingchong; Ji, Shengchao; Yang, Chensong; Zhang, Tianhao; Han, Ning; Pan, Yutao; Xu, Xiaodong; Jiang, Lin; Sun, Guixin

doi:10.1007/s40520-022-02243-4

Cited by 14 publications

(19 citation statements)

References 44 publications

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“…The current study showed that the CONUT score was significantly inversely correlated with Hb, PAB and RBP and was sig- PAB represents protein content and RBP is associated with protein metabolism. 23,24 The results of the current study suggested that the CONUT score could be used to assess the nutritional status of UC patients. FC is a calcium-binding protein derived from colonic mucosal neutrophils and it is a critical biomarker for evaluating the activity of UC.…”

Section: Discussionmentioning

confidence: 82%

Association with controlling nutritional status score and disease activity of ulcerative colitis

Lian,

Hu,

Cheng

et al. 2023

J Int Med Res

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Objective To explore the association between the controlling nutritional status (CONUT) score and disease activity in patients with ulcerative colitis (UC). Methods This retrospective study enrolled patients with UC. Demographic, clinical and laboratory data were collected and compared. The CONUT score was obtained for each patient. The association between the CONUT score and laboratory parameters was analysed and the ability of the score to assess disease activity was evaluated. Results A total of 182 patients with UC were enrolled. Patients with active disease showed significantly increased inflammatory biomarkers and decreased nutritional biomarkers compared with patients in remission. Malnourished individuals had significantly elevated inflammatory biomarkers and significantly reduced haemoglobin, prealbumin and retinol-binding protein. The CONUT score was inversely correlated with haemoglobin, prealbumin, retinol-binding protein and was positively correlated with faecal calprotectin, C-reactive protein, erythrocyte sedimentation rate, neutrophil/lymphocyte ratio and platelet/lymphocyte ratio. The area under the receiver operating characteristic curve was 0.655 (95% confidence interval, 0.557–0.752). The optimal cut-off value was 1.5 points, with a sensitivity of 75.7% and a specificity of 50.0%. Conclusion The CONUT score may evaluate the inflammatory response and nutritional status of UC patients, so it could be a potential biomarker to assess disease activity in UC.

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Section: Discussionmentioning

confidence: 82%

Association with controlling nutritional status score and disease activity of ulcerative colitis

Lian,

Hu,

Cheng

et al. 2023

J Int Med Res

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“…After reviewing the titles, abstracts, and full texts, 9 retrospective studies were eventually included in this meta-analysis. [22][23][24][25][26][27][28][29][30]…”

Section: Literature Search and Selectionmentioning

confidence: 99%

“…Year Country Sample size Gender (male/female) Age Cutoff value Follow-up NOS Kotera [22] 2019 Japan 607 114/493 87 ± 6 82 180 d 7 Hao [23] 2020 USA 290 21,773 82 ± 7 92, 98 60 d 6 Yokoyama [24] 2021 Japan 137 29/108 79.6 ± 8.8/83.3 ± 6.9 92 180 d 6 Zhao [25] 2021 China 135 63/72 74.69 ± 13.24 74.59 365 d 7 Fujimoto [26] 2022 Japan 109 24/85 84 (78-89) 82, 92, 98 365 d 6 Tsutsui [30] 2022 Japan 623 128/495 82 (60-101) Continuous 4 yr (0-7 yr) 7 Funahashi [27] 2022 Japan 1113 242/798 84.7 ± 7.8 75.4 30 d 8 Liu [28] 2022 China 546 171/375 75.19 ± 10.23 98 365 d 6 Meng [29] 2022 muscle mass, a condition known as sarcopenia. [32,33] Sarcopenia weakens muscle strength, increasing susceptibility to losing balance when individuals fall, thus increasing the risk of hip fractures due to falls.…”

Section: Authormentioning

confidence: 99%

Geriatric nutritional risk index predicts postoperative prognosis in older patients with hip fracture: A meta-analysis

Liu,

Xie

2024

Medicine

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Background: Hip fracture is common in elderly individuals and is accompanied by a relatively high mortality rate. However, it is currently difficult to accurately predict postoperative prognosis for older patients with hip fractures. The aim of this meta-analysis was to further determine the prognostic value of the geriatric nutritional risk index (GNRI) for patients who underwent hip fracture surgery. Methods: The Medline, EMBASE, Web of Science, and CNKI databases were searched up to September 19, 2023, for available studies. The primary and secondary outcomes were the mortality and complication rates, respectively. Hazard ratios (HRs) and relative risks with corresponding 95% confidence intervals (CIs) were separately combined to assess the associations between the GNRI and mortality and complication rates. All the statistical analyses were performed with STATA 15.0 and SPSS 22.0 software. Results: A total of 9 studies with 3959 patients were included. The pooled results demonstrated that a lower GNRI was significantly related to an increased risk of postoperative mortality (HR = 0.82, 95% CI = 0.72–0.92, P = .001). In addition, the GNRI predicted the risk of overall postoperative complications (52% vs 35.5%, P = .04) and pneumonia (33.3% vs 13.6%, P = .010). Conclusion: The GNRI might serve as a novel prognostic indicator for older patients with hip fractures, and a lower GNRI indicates an increased risk of postoperative mortality and complication rates.

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“…In a retrospective study of 161,625 patients who underwent TKA, Roche et al demonstrated increased rates of infections and wounds with prealbumin levels of <15 mg/dL 33 . In a retrospective study of 546 patients with hip fracture, Liu et al observed increased mortality and decreased ability to walk freely 6 months and 1 year postoperatively for patients with preoperative prealbumin of <14.65 mg/dL 44 . In the neurosurgery literature, prealbumin of <20 mg/dL was associated with an increased risk of infection following spine surgery 5,6 .…”

Section: Serologic Markersmentioning

confidence: 99%

Nutrition in Surgery: An Orthopaedic Perspective

Zink,

Kent,

Choudhary

et al. 2023

Journal of Bone and Joint Surgery

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➤ Malnutrition is common among subsets of patients undergoing orthopaedic surgery and is associated with an increased risk of postoperative complications.➤ Serum proteins, in particular, albumin, may be used in the evaluation of nutritional status.➤ Anthropometric measurements and surveys also play a role in the evaluation of nutritional status.➤ Increased energy and nutrient requirements due to surgical procedures necessitate increased caloric and protein intake in the perioperative period, which may be achieved through diet or supplementation.➤ Evidence supports the use of protein-calorie, amino acid, and immunonutrition supplements. Vitamin D supplementation is an area of further consideration.➤ Diet restriction, activity alterations, pharmacotherapy, and bariatric surgery are all safe, effective approaches to weight loss, although the optimal timing and magnitude of preoperative weight loss require further investigation.

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Prealbumin as a nutrition status indicator may be associated with outcomes of geriatric hip fractures: a propensity score matching and 1-year follow-up study

Cited by 14 publications

References 44 publications

Association with controlling nutritional status score and disease activity of ulcerative colitis

Association with controlling nutritional status score and disease activity of ulcerative colitis

Geriatric nutritional risk index predicts postoperative prognosis in older patients with hip fracture: A meta-analysis

Nutrition in Surgery: An Orthopaedic Perspective

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