Preadipocyte response and impairment of differentiation in an inflammatory environment

Poulain‐Godefroy, Odile; Froguel, Philippe

doi:10.1016/j.bbrc.2007.03.053

Cited by 64 publications

(69 citation statements)

References 35 publications

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“…Indirect co-culture experiments on MDM indicated that the phenotype of ATM is related specifically to factors released by the preadipocytes, whereas lipids released from mature adipocytes do not induce these effects. These data are in line with previous observations, suggesting the high proinflammatory potential of preadipocytes (5,6).…”

Section: Discussionsupporting

confidence: 93%

“…ATM are surrounded by preadipocytes and adipocytes, and it is likely that paracrine loops exist via the production of adipokines, free fatty acids, and derived mediators, leading to inflammatory changes. In particular, preadipocytes produce higher levels of proinflammatory cytokines compared with adipocytes, suggesting that they play an important role in the induction and maintenance of inflammation (5,6) and may thus operate as ATM activators.…”

mentioning

confidence: 99%

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Human Adipose Tissue Macrophages Display Activation of Cancer-related Pathways

Mayi

Daoudi

Derudas

et al. 2012

Journal of Biological Chemistry

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Section: Discussionsupporting

confidence: 93%

mentioning

confidence: 99%

Human Adipose Tissue Macrophages Display Activation of Cancer-related Pathways

Mayi

Daoudi

Derudas

et al. 2012

Journal of Biological Chemistry

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“…In the past 2 years, different studies showed that TLR4 has an important role in obesity-induced insulin resistance, and that mice with a loss-of-function mutation or knockout for TLR4 are protected from diet-induced insulin resistance (Senn 2006, Shi et al 2006, Song et al 2006, Kim et al 2007, Nguyen et al 2007, Poggi et al 2007, Poulain-Godefroy & Froguel 2007, Tsukumo et al 2007. Our data show that TLR2 may also have a role in the interface of subclinical inflammation and insulin resistance in DIO mice.…”

Section: Discussionmentioning

confidence: 51%

“…Upon stimulation, TLR recruits IL1R1-associated protein kinases via adaptor MYD88, and finally induces the activation of nuclear factor-kB and mitogen-activated protein kinases, as well as the expression of inflammatory cytokines (Aderem & Ulevitch 2000, Heldwein & Fenton 2002, Akira & Sato 2003. Preliminary studies have indicated that loss-of-function mutation and knockout in TLR4 prevents insulin resistance induced by obesity or free fatty acids, suggesting an important role of TLR4 in the interface of innate immune system and energetic metabolism (Shi et al 2006, Song et al 2006, Kim et al 2007, Nguyen et al 2007, Poggi et al 2007, Poulain-Godefroy & Froguel 2007, Tsukumo et al 2007.…”

Section: Introductionmentioning

confidence: 99%

Inhibition of toll-like receptor 2 expression improves insulin sensitivity and signaling in muscle and white adipose tissue of mice fed a high-fat diet

Caricilli¹,

Nascimento²,

Pauli³

et al. 2008

Journal of Endocrinology

117

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The aims of the present study were to investigate the expression of toll-like receptor 2 (TLR2) in muscle and white adipose tissue (WAT) of diet-induced obesity (DIO) mice, and also the effects of its inhibition, with the use of TLR2 antisense oligonucleotide (ASON), on insulin sensitivity and signaling. The expression of TLR2 was increased in muscle and WAT of DIO mice, compared with those that received standard chow. Inhibition of TLR2 in DIO mice, by TLR2 ASON, improved insulin sensitivity and signaling in muscle and WAT. In addition, data show that the inhibition of TLR2 expression prevents the activation of IKBKB, MAPK8, and serine phosphorylation of IRS1 in DIO mice, suggesting that TLR2 is a key modulator of the crosstalk between inflammatory and metabolic pathways. We, therefore, suggest that a selective interference with TLR2 presents an attractive opportunity for the treatment of insulin resistance in obesity and type 2 diabetes.

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“…RANTES is expressed by adipocytes and has been hypothesized to mediate leukocyte infiltration of adipose tissue in obesity (2,3). Circulating RANTES concentrations are elevated in obesity, impaired glucose tolerance (IGT), and type 2 diabetes (4,5).…”

Section: Introductionmentioning

confidence: 99%

RANTES/CCL5 gene polymorphisms, serum concentrations, and incident type 2 diabetes: results from the MONICA/KORA Augsburg case–cohort study, 1984–2002

Herder

Illig

Baumert

et al. 2008

European Journal of Endocrinology

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Objective: Regulated on activation, normal T-cell expressed and secreted (RANTES)/chemokine(C-C motif) ligand (CCL5) is expressed by adipocytes, and serum levels of RANTES are increased in obesity and type 2 diabetes. The aim of this study was to test the hypothesis that RANTES is involved in the pathogenesis of type 2 diabetes by analyzing the triangular association between CCL5 gene polymorphisms, systemic RANTES concentrations, and incident type 2 diabetes in a large prospective study. Subjects and methods:The study is based on 502 individuals (293 men and 209 women) and 1632 individuals (859 men and 773 women) with and without incident type 2 diabetes from the populationbased MONItoring of Trends and Determinants in Cardiovascular Disease (MONICA)/Cooperative Health Research in the Region of Augsburg (KORA) case-cohort study respectively (mean follow-up timeGS.D. 10.1G4.9 years). CCL5 genotypes and RANTES serum concentrations were determined and associations between genotypes, haplotypes, serum levels, and incident type 2 diabetes were assessed. Results: Minor alleles of four single nucleotide polymorphisms were associated with lower RANTES levels (P additive between 1.2!10 K9 and 3.1!10 K8), but neither genotypes, haplotypes, nor serum levels were associated with incident type 2 diabetes. Conclusions: Our data suggest that RANTES/CCL5 gene variants and serum levels are not causally related with type 2 diabetes and that elevated RANTES levels in patients with type 2 diabetes may be a consequence of hyperglycemia. However, our findings cannot preclude a local role in adipose tissue where RANTES expression may contribute to leukocyte infiltration and a proinflammatory state. European Journal of Endocrinology 158 R1-R5

show abstract

Preadipocyte response and impairment of differentiation in an inflammatory environment

Cited by 64 publications

References 35 publications

Human Adipose Tissue Macrophages Display Activation of Cancer-related Pathways

Human Adipose Tissue Macrophages Display Activation of Cancer-related Pathways

Inhibition of toll-like receptor 2 expression improves insulin sensitivity and signaling in muscle and white adipose tissue of mice fed a high-fat diet

RANTES/CCL5 gene polymorphisms, serum concentrations, and incident type 2 diabetes: results from the MONICA/KORA Augsburg case–cohort study, 1984–2002

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