Pre-vaccine plasma levels of soluble inflammatory indices negatively predict responses to HAV, HBV, and tetanus vaccines in HCV and HIV infection

Shive, Carey L.; Judge, Chelsey J.; Clagett, Brian; Kalayjian, Robert C.; Osborn, Melissa; Sherman, Kenneth E.; Fichtenbaum, Carl J.; Gandhi, Rajesh T.; Kang, Min-Hee; Popkin, Daniel L.; Sieg, Scott F.; Lederman, Michael M.; Rodrı́guez, Benigno; Anthony, Donald D.

doi:10.1016/j.vaccine.2017.12.018

Cited by 19 publications

(22 citation statements)

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“…Numerous studies have demonstrated increased expression of and serum levels of IL‐6, TNF‐ α, sTNFR, sCD163, and sCD14 among CHC patients compared to healthy controls (Table ) and those with other hepatic diseases such as alcoholic liver disease . In addition, increased serum levels of IL‐10, or disturbances in the ratios of proinflammatory/anti‐inflammatory cytokines TNF‐α/IL‐10 and IL‐6/IL‐10 have been noted among CHC patients compared to healthy controls .…”

Section: Resultsmentioning

confidence: 99%

“…21 TNF-dependent processes are up regulated and activated in CHC, and TNF-α mRNA is ubiquitously expressed in hepatocytes, Kupffer cells, and infiltrating mononuclear cells at higher levels in CHC patients than in healthy controls. 22,23 31 Falasca et al 32 Helaly et al 33 Khan et al 34 Migita et al 36 Zekri et al 37 Malaguarnera et al 38 Costantini et al 39 Capone et al 40 Oyanagi et al 41 Lapinski et al 42 Lecube et al 43 Sandler et al 44a Grungreiff et al 46a Cotler et al 48a Hung et al 49 Antonelli et al 50 Shive et al 52 Cua et al 53 Grungreiff et al 54 Lee et al 84 Mishra et al 87 Sousa et al 91 Tsui et al 35 Zuwała-Jagiełło et al 57 Mourtzikou et al 58 Han et al 85 Müller et al 92…”

Section: Biomarkers Of Inflammationmentioning

confidence: 99%

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Inflammatory and cardiovascular diseases biomarkers in chronic hepatitis C virus infection: A review

Babiker

Hassan

Muhammed

et al. 2019

Clinical Cardiology

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Hepatitis C virus (HCV) infects 180 million people worldwide and over 4 million people in the United States. HCV infection is a major cause of chronic liver disease and is recognized as a risk factor for clinical cardiovascular disease (CVD). Many studies have shown increased prevalence of cardiac and inflammatory biomarkers in patients with chronic HCV infection (CHC), and though these markers may be used to risk stratify people for cardiac disease in the general population their role in the HCV population is unknown. Patients with CHC have elevated cardiac and inflammatory biomarkers compared to noninfected controls which may play a role in CVD risk stratification. We undertook a systematic review of inflammatory and cardiac biomarkers in people with HCV infection with a focus on the effect of CHC on serum levels of these markers and their utility as predictors of CVD in this population. Medline, EMBASE, and Cochrane databases were searched for relevant articles until June 2019. A total of 2430 results were reviewed with 115 studies included. Our review revealed that HCV infection significantly alters serum levels of markers of inflammation, endothelial function, and cardiac dysfunction prior to HCV treatment, and some of which may change in response to HCV therapy. Current risk stratification tools for development of CVD in the general population may not account for the increased inflammatory markers that appear to be elevated among HCV‐infected patients contributing to increased CVD risk.

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Section: Resultsmentioning

confidence: 99%

Section: Biomarkers Of Inflammationmentioning

confidence: 99%

Inflammatory and cardiovascular diseases biomarkers in chronic hepatitis C virus infection: A review

Babiker

Hassan

Muhammed

et al. 2019

Clinical Cardiology

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“…Suboptimal vaccine responses with aging have been associated with alterations in cellular pathways, such as increased TNF-NFkB signaling or activity (16). For example, several studies observed a weak negative correlation between serum TNF and vaccine responses (9,(17)(18)(19). However, therapeutic anti-TNF antibody treatment paradoxically did not result in improved humoral responses and instead led to reduced vaccine-induced antibody responses to pneumococcal and influenza vaccines (20)(21)(22).…”

Section: Main Textmentioning

confidence: 99%

Vaccine-induced ICOS+CD38+ cTfh are sensitive biosensors of age-related changes in inflammatory pathways

Herati

Silva

Vella

et al. 2019

Preprint

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Humoral immune responses are dysregulated with aging but details remain incompletely understood. In particular, little is known about the effects of aging on T follicular helper (Tfh) CD4 cells, the subset that provides critical help to B cells for effective humoral immunity. We previously demonstrated that influenza vaccination increases a circulating Tfh (cTfh) subset that expresses ICOS and CD38, contains influenza-specific memory cells, and is correlated with antibody responses. To directly study the effects of aging on the cTfh response, we performed transcriptional profiling and cellular analysis before and after influenza vaccination in young and elderly adults. Several key differences in cTfh responses were revealed in the elderly. First, whole blood transcriptional profiling defined cross-validated genesets of youth versus aging and these genesets were, compared to other T cells, preferentially enriched in ICOS+CD38+ cTfh from young and elderly subjects, respectively, following vaccination. Second, vaccine-induced ICOS+CD38+ cTfh from the elderly were enriched for transcriptional signatures of inflammation including TNF-NFkB pathway activation. Indeed, we reveal a paradoxical positive effect of TNF signaling on Tfh providing help to B cells linked to survival circuits that may explain detrimental effects of TNF blockade on vaccine responses. Finally, vaccine-induced ICOS+CD38+ cTfh displayed strong enrichment for signatures of underlying age-associated biological changes.Thus, these data reveal key biological changes in cTfh during aging and also demonstrate the sensitivity of vaccine-induced cTfh to underlying changes in host physiology. This latter observation suggests that vaccine-induced cTfh could function as sensitive biosensors of underlying inflammatory and/or overall immune health. Main Text:Influenza vaccination induces strain-specific neutralizing antibodies in healthy adults, but this process is impaired with aging (1-4). Moreover, immunological aging, that may or may not be directly linked to chronological aging, is also associated with increased morbidity and mortality from infectious diseases (5,6). Studies of immunological aging and vaccines have identified mechanisms including alterations at the subcellular (7, 8), cellular (9, 10), and systems levels (11)(12)(13)(14) that lead to altered vaccine responses. Vaccination strategies that can effectively combat age-associated immune dysfunction are of great interest for rational vaccine design. Moreover, identifying strategies to define critical characteristics of overall immune fitness during aging would be of considerable utility for selecting appropriate immunological and other interventions for disease.The production of class-switched, affinity-matured antibody by B cells is dependent on help from T follicular helper (Tfh) cells in germinal centers (GC) in lymphoid tissues (15), but few studies have evaluated the effects of aging on the GC reaction and GC dependent cellular responses in humans. Suboptimal vaccine responses with aging ...

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“…Importantly, plasma levels of soluble inflammatory markers before vaccination negatively predicted responses to HAV, HBV, and tetanus vaccines in HCV and HIV infection [ 36 ]. Moreover, hsCRP levels were a significant predictor of herpes zoster vaccine response in elderly nursing home residents [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

Improved CD4 T cell profile in HIV-infected subjects on maraviroc-containing therapy is associated with better responsiveness to HBV vaccination

et al. 2018

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BackgroundMaraviroc-containing combined antiretroviral therapy (MVC-cART) improved the response to the hepatitis B virus (HBV) vaccine in HIV-infected subjects younger than 50 years old. We aimed here to explore the effect of this antiretroviral therapy on different immunological parameters that could account for this effect.MethodsWe analysed baseline samples of vaccinated subjects under 50 years old (n = 41). We characterized the maturational subsets and the expression of activation, senescence and prone-to-apoptosis markers on CD4 T-cells; we also quantified T-regulatory cells (Treg) and dendritic cell (DC) subsets. We used binary logistic regression to evaluate the immunological impact of MVC-cART, correlation with MVC exposure and linear regression for association with the magnitude of the HBV vaccine response.ResultsHIV-infected subjects on MVC-cART prior to vaccination showed increased recent thymic emigrants levels and reduced myeloid-DC levels. A longer exposure to MVC-cART was associated with lower frequencies of Tregs and activated and proliferating CD4 T-cells. Furthermore, the frequencies of activated and proliferating CD4 T-cells were inversely associated with the magnitude of the HBV vaccine response.ConclusionThe beneficial effect of MVC-cART in the HBV vaccine response in subjects below 50 years old could be partially mediated by its reducing effect on the frequencies of activated and proliferating CD4 T-cells prior to vaccination.Electronic supplementary materialThe online version of this article (10.1186/s12967-018-1617-1) contains supplementary material, which is available to authorized users.

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Pre-vaccine plasma levels of soluble inflammatory indices negatively predict responses to HAV, HBV, and tetanus vaccines in HCV and HIV infection

Abstract: During HCV and HIV infection markers of systemic inflammation reflect immune dysfunction as demonstrated by poor response to HAV/HBV neo-antigen vaccine.

Cited by 19 publications

References 50 publications

Inflammatory and cardiovascular diseases biomarkers in chronic hepatitis C virus infection: A review

Inflammatory and cardiovascular diseases biomarkers in chronic hepatitis C virus infection: A review

Vaccine-induced ICOS+CD38+ cTfh are sensitive biosensors of age-related changes in inflammatory pathways

Improved CD4 T cell profile in HIV-infected subjects on maraviroc-containing therapy is associated with better responsiveness to HBV vaccination

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