Abstract:Background: The newly developed mRNA-based COVID-19 vaccines can provoke
anaphylaxis, possibly induced by polyethylene glycol (PEG) contained in
the vaccine. The management of persons with a history of PEG allergy, or
with an allergic-like reaction after the first dose remains to be
defined. Methods: We studied two cohorts of individuals: one
pre-vaccination, the second post-vaccination. Skin testing was performed
with COVID-19 mRNA vaccines. Upon negative skin test, a two-step
(10%-90%) vaccination protocol … Show more
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