Pre-treatment with high density lipoprotein (HDL) attenuates the renal and hepatic dysfunction caused by endotoxin in rats

Dhadly, Pal; McDonald, Michelle C.; Cockerill, Gillian; Hinds, C. J.; Miller, N. E.; Thiemermann, Christoph

doi:10.1093/bja/84.5.688-a

Cited by 2 publications

(1 citation statement)

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“…A possible reason for this observation is that the traditional standard for ultrasound fatty liver diagnosis is relatively subjective and Table 4 Comparison of fatty liver diagnosis by the ultrasound quantitative model, the ultrasound hepatic/renal ratio, the hepatic echo-intensity attenuation rate, and conventional ultrasound can easily result in misdiagnosis [14][15][16] . However, a computer-assisted quantitative ultrasound model makes the fatty liver objective and quantitative, which cannot easily be influenced by subjective factors and avoids subjective deviation [5,17,18] . Meanwhile, this method can accurately provide quantitative liver fat content information; overcoming the limitations of a qualitative-only diagnosis performed by conventional ultrasound.…”

Section: Efficacy Comparison Of the Quantitative Ultrasound Model Andmentioning

confidence: 99%

Ultrasound hepatic/renal ratio and hepatic attenuation rate for quantifying liver fat content

Zhang

Ding

Chen

et al. 2014

WJG

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AIM:To establish and validate a simple quantitative assessment method for nonalcoholic fatty liver disease (NAFLD) based on a combination of the ultrasound hepatic/renal ratio and hepatic attenuation rate. METHODS:A total of 170 subjects were enrolled in this study. All subjects were examined by ultrasound and 1 H-magnetic resonance spectroscopy ( 1 H-MRS) on the same day. The ultrasound hepatic/renal echointensity ratio and ultrasound hepatic echo-intensity attenuation rate were obtained from ordinary ultrasound images using the MATLAB program. RESULTS:Correlation analysis revealed that the ultrasound hepatic/renal ratio and hepatic echo-intensity attenuation rate were significantly correlated with 1 H-MRS liver fat content (ultrasound hepatic/renal ratio: r = 0.952, P = 0.000; hepatic echo-intensity attenuation r = 0.850, P = 0.000). The equation for predicting liver fat content by ultrasound (quantitative ultrasound model) is: liver fat content (%) = 61.519 × ultrasound hepatic/renal ratio + 167.701 × hepatic echo-intensity attenuation rate -26.736. Spearman correlation analysis revealed that the liver fat content ratio of the quantitative ultrasound model was positively correlated with serum alanine aminotransferase, aspartate aminotransferase, and triglyceride, but negatively correlated with high density lipoprotein cholesterol. Receiver operating characteristic curve analysis revealed that the optimal point for diagnosing fatty liver was 9.15% in the quantitative ultrasound model. Furthermore, in the quantitative ultrasound model, fatty liver diagnostic sensitivity and specificity were 94.7% and 100.0%, respectively, showing that the quantitative ultrasound model was better than conventional ultrasound methods or the combined ultrasound hepatic/renal ratio and hepatic echo-intensity attenuation rate. If the 1 H-MRS liver fat content had a value < 15%, the sensitivity and specificity of the ultrasound quantitative model would be 81.4% and 100%, which still shows that using the model is better than the other methods. CONCLUSION:The quantitative ultrasound model is a simple, low-cost, and sensitive tool that can accurately assess hepatic fat content in clinical practice. It provides an easy and effective parameter for the early diagnosis of mild hepatic steatosis and evaluation of the efficacy of NAFLD treatment. Key words: Non-alcoholic fatty liver disease; Ultrasound hepatic/renal ratio; Ultrasound hepatic echo-intensity attenuation rateCore tip: The quantitative ultrasound model is a simple, low-cost, and sensitive tool that can accurately assess hepatic fat content in clinical practice. It provides an easy and effective parameter for early diagnosis of mild hepatic steatosis and evaluation of the efficacy of Zhang B, Ding F, Chen T, Xia LH, Qian J, Lv GY. Ultrasound hepatic/renal ratio and hepatic attenuation rate for quantifying liver fat content.

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