Pre-treatment Neutrophil-to-Lymphocyte Ratio as a predictor for occult cervical metastasis in early stage (T1-T2 cN0) squamous cell carcinoma of the oral tongue

Abbate, Vincenzo; Orabona, Giovanni Dell’Aversana; Salzano, Giovanni; Bonavolontà, Paola; Maglitto, Fabio; Romano, Antonio; Tarabbia, Filippo; Turri‐Zanoni, Mario; Attanasi, Federica; Lauro, Alessandro; Iaconetta, Giorgio; Califano, Luigi

doi:10.1016/j.suronc.2018.06.002

Cited by 35 publications

(38 citation statements)

References 37 publications

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“…Many predictive factors, such as NLR, tobacco and alcohol use, histologic grade, minimum size, and neural infiltration of tumor, have been identified to be related to lymph node metastasis of OTSCC, 10,11,24 and our data showed similar results ( Table 1, Fig 4). Recent studies have found that NLR plays a critical role in tumor metastasis and prognosis, probably because of tumor-promoting inflammation.…”

Section: Discussionsupporting

confidence: 80%

Machine Learning Predicts Lymph Node Metastasis in Early-Stage Oral Tongue Squamous Cell Carcinoma

Shan

Jiang

Chen

et al. 2020

Journal of Oral and Maxillofacial Surgery

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Section: Discussionsupporting

confidence: 80%

Machine Learning Predicts Lymph Node Metastasis in Early-Stage Oral Tongue Squamous Cell Carcinoma

Shan

Jiang

Chen

et al. 2020

Journal of Oral and Maxillofacial Surgery

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“…On the other hand, it was interesting to find that the NLR value was significantly lower in the young patients than in the old patients, and previous strong evidence has shown that a high NLR value is a predictor of a worse prognosis in head and neck SCC 3–7. Additionally, although we did not have the HPV status of the patients, because of the higher sexual activity in young patients, there might be higher rate of HPV infection in young patients, and several authors had shown the correlation between HPV + and better prognosis in young people 19,20. Furthermore, other unassessed factors, including poor oral hygiene and poor dentures in the old patients, might also be responsible for this finding.…”

Section: Discussionmentioning

confidence: 89%

<p>Significance of the neutrophil-to-lymphocyte ratio in young patients with oral squamous cell carcinoma</p>

Zhang¹,

Du²,

Gan³

et al. 2019

CMAR

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Background The main goal of this study was to evaluate the prognosis of young patients with oral squamous cell carcinoma (SCC) with a focus on the value of the pretreatment neutrophil-to-lymphocyte ratio (NLR). Materials and methods Young (≤40 years old) patients with oral SCC were retrospectively enrolled, and each young patient was matched with an old (≥60 years old) oral SCC patient. Associations between the NLR and clinicopathological variables were analyzed by the chi-square test, and the Kaplan–Meier method was used to analyze recurrence-free survival (RFS) and disease-specific survival (DSS) rates. Results A total of 103 young patients were enrolled, and compared to the old group, the young group had a significantly lower NLR value ( p =0.012). In the young group, the 5-year RFS and DSS rates were 82% and 85%, respectively. In the old group, the 5-year RFS and DSS rates were 65% and 71%, respectively, and the differences between the groups were significant (both p <0.05). In the young patients with an NLR≤2.56, the 5-year DSS rate was 93%, while in the young patients with an NLR >2.56, the 5-year DSS rate was 76%. This difference was significant ( p =0.020). A further Cox model analysis confirmed that the NLR was an independent prognostic factor for DSS. Conclusion Young patients with oral SCC have a better prognosis than old oral SCC patients, and the NLR is significantly associated with DSS in young patients.

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“…High NLR is thought to be significantly associated with worse survival in solid cancers (28). Abbate et al (30) firstly presented there was higher risk for occult neck lymph node metastasis when pre-treatment NLR was greater than 2.93. Loganathan et al (31) recently reported END should be considered when the tumor thickness exceeds 5 mm based on the significant relationship between tumor thickness and occult neck lymph node metastasis.…”

Section: Discussionmentioning

confidence: 99%

Lingual Lymph Node Metastasis in cT1-2N0 Tongue Squamous Cell Carcinoma: Is It an Indicator for Elective Neck Dissection

et al. 2020

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Objective: Accurate predictors for occult metastasis in cT1-2N0 tongue squamous cell carcinoma (SCC) remains scarce, the main goal in current study was to evaluate whether there is significant association between lingual lymph node (LLN) metastasis and occult lymph node metastasis as well as whether there is prognostic value of LLN metastasis in early stage tongue SCC. Methods: Patients with surgically treated primary cT1-2N0 tongue SCC were prospectively enrolled from January 2010 to December 2018. LLNs were dissected independently for pathologic analysis. The main study endpoints were locoregional control survival (LRC) and disease-specific survival (DSS). The Chi-square test and multivariate regression analysis were used to assess the predictors for occult metastasis. The Kaplan-Meier approach and Cox model were used to analyze the potential prognostic factors. Results: A total of 317 patients were enrolled for analysis. Eighty-eight patients had occult metastasis with a prevalence of 27.8%. LLNs presented in 89 patients, in which 43 patients had LLN metastasis. In the 43 patients with positive LLNs, 20 patients had occult metastasis, in 274 patients with negative LLNs or no LLNs, 68 patients had occult metastasis, the difference was significant (p = 0.012). Further multivariate regression analysis confirmed the independence of LLN metastasis in predicting the occult metastasis. In patients without LLNs, the 5-year LRC rate was 79%, in patients with negative LLNs, the 5-year LRC rate was 78%, in patients with positive LLNs, the 5-year LRC rate was 62%, the difference was significant (p = 0.024). In patients without LLNs, the 5-year DSS rate was 84%, in patients with negative LLNs, the 5-year DSS rate was 74%, in patients with positive LLNs, the 5-year DSS rate was 51%, the difference was significant (p < 0.001), further Cox model confirmed the independence of LLN metastasis in affecting the LRC and DSS. Conclusions: LLN metastasis is significantly associated with occult neck lymph node metastasis, and decrease the LRC and DSS in early stage tongue SCC.

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Pre-treatment Neutrophil-to-Lymphocyte Ratio as a predictor for occult cervical metastasis in early stage (T1-T2 cN0) squamous cell carcinoma of the oral tongue

Cited by 35 publications

References 37 publications

Machine Learning Predicts Lymph Node Metastasis in Early-Stage Oral Tongue Squamous Cell Carcinoma

Machine Learning Predicts Lymph Node Metastasis in Early-Stage Oral Tongue Squamous Cell Carcinoma

<p>Significance of the neutrophil-to-lymphocyte ratio in young patients with oral squamous cell carcinoma</p>

Lingual Lymph Node Metastasis in cT1-2N0 Tongue Squamous Cell Carcinoma: Is It an Indicator for Elective Neck Dissection

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