Abstract:Background: Although ketamine can rapidly decrease suicidal ideation (SI), its neurobiological mechanism of action remains unclear. Several areas of the cingulate cortex have been implicated in SI; therefore, we aimed to explore the neural correlates of the anti-suicidal effect of ketamine with cingulate cortex functional connectivity (FC) in depression.Methods: Forty patients with unipolar or bipolar depression with SI underwent six infusions of ketamine over two weeks. Clinical symptoms and resting-state fun… Show more
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