Pre-treatment antinuclear antibody positivity, therapeutic efficacy and persistence of biologics in rheumatoid arthritis

Codreanu, Cătălin; Mogoşan, Corina; Popescu, C; Rednic, Simona; Popovici, Horațiu; Parvu, M.; Opriş, D.; Ionescu, Ruxandra

doi:10.1515/rrlm-2016-0018

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2019

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“…Tobacco use leads to a poor response to methotrexate administered in monotherapy. smoker's resistance to therapy may be caused by the pharmacokinetic interactions between drugs and tobacco constituents that stimulate the metabolic rate (4,5). smoking cessation may have a positive effect on ra patients, but the risk in former smokers is minimized only after 10 or even 20 years.…”

Section: Introductionmentioning

confidence: 99%

Etiopathogenic mechanisms of tobacco constituents in rheumatoid arthritis

Macovei¹,

Cardoneanu²,

Burlui³

et al. 2019

Ro J Rheumatol.

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Active smoking is considered a risk factor for rheumatoid arthritis. Smokers show respiratory extra-articular manifestations and complications, such as interstitial lung disease and chronic obstructive pulmonary disease. Smokers may receive a more intensive drug therapy than non-smokers, but they have a poor prognosis. Smoker's resistance to therapy may be caused by the pharmacokinetic interactions between drugs and tobacco constituents. The present account of some of those thousands of components of the gas and tar phase of cigarette smoke (polynuclear aromatic hydrocarbons, quinones, cyanide, heavy metals, bacterial endotoxins, nicotine and carbon monoxide) may help explain the inconclusive incrimination of tobacco use in the development of rheumatoid arthritis and convince more clinicians to recommend smoking cessation.

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Section: Introductionmentioning

confidence: 99%