Pre-training Catechin gavage prevents memory impairment induced by intracerebroventricular streptozotocin in rats

Zamani, Marzieh; Rohampour, Kambiz; Zeraati, Maryam; Hosseinmardi, Narges; Kazemian, Mostafa M.

doi:10.17712/nsj.2015.3.20140440

Cited by 8 publications

(2 citation statements)

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“…The passive avoidance task was used to examine the memory acquisition and retrieval based on the negative reinforcement, as described elsewhere (28). Shortly, the step-through passive avoidance apparatus consisted of a light and a dark chamber (30 cm × 20 cm × 20 cm each).…”

Section: Behavioral Assessmentmentioning

confidence: 99%

Intracerebroventricular administration of adiponectin attenuates streptozotocin-induced memory impairment in rats

et al. 2017

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Alzheimer's disease (AD) has been reported to be linked with diabetes mellitus and insulin resistance. Adiponectin (ADN), an adipocytokine secreted from adipose tissue, is involved in the regulation of insulin sensitivity, energy homeostasis, and mitochondrial dysfunction. In this study, we examined the effect of ADN on passive avoidance memory in animal model of sporadic AD (sAD). On days 1 and 3 after cannulation, rats received intracerebroventricular (icv) injection of streptozotocin (STZ) (3 mg/kg). Thirty minutes before the learning process, animals received saline or ADN in different doses (6, 60, and 600 µg). The step-through latency (STL) and total time spent in the dark compartment (TDC) were recorded and analyzed. In STZ-treated rats, STL was significantly decreased, whereas TDC showed a dramatic increase. In ADN-treated rats, STL was significantly increased (P < 0.01) in all treatment doses. The number of entries was decreased in all applied doses; however, TDC was reduced only by the application of 6 ng of ADN (P < 0.05). It can be concluded that ADN is useful to improve the STZ-induced memory impairment. This study showed, for the first time, that icv administration of ADN could improve the memory acquisition in animal model of sAD.

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Section: Behavioral Assessmentmentioning

confidence: 99%

Intracerebroventricular administration of adiponectin attenuates streptozotocin-induced memory impairment in rats

et al. 2017

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“…This flavanol has shown numerous biological effects such as: decrease risk of cardiovascular dysfunction, metabolism regulation, skeletal muscle cells differentiation induction, among others [2,3,4,5,6,7]. However, despite its various positive effects there is little evidence demonstrating the mechanism(s) through which EC initiates those effects.…”

Section: Introductionmentioning

confidence: 99%

PXR is a target of (-)-epicatechin in skeletal muscle

Ortiz-Flores

Portilla-Martínez

Cabrera-Pérez

et al. 2020

Heliyon

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Epicatechin (EC) is a flavanol that has shown numerous biological effects such as: decrease risk of cardiovascular dysfunction, metabolism regulation, skeletal muscle (SkM) performance improvement and SkM cells differentiation induction, among others. The described EC acceptor/receptor molecules do not explain the EC's effect on SkM. We hypothesize that the pregnane X receptor (PXR) can fulfill those characteristics, based on structural similitude between EC and steroidal backbone and that PXR activation leads to similar effects as those induced by EC. In order to demonstrate our hypothesis, we: 1) analyzed the possible EC and mouse PXR interaction through in silico strategies, 2) developed an EC's affinity column to isolate PXR, 3) evaluated, in mouse myoblast (C2C12 cells) the inhibition of EC-induced PXR's nucleus translocation by ketoconazole, a specific blocker of PXR and 4) analyzed the effect of EC as an activator of mouse PXR, evaluating the expression modulation of cytochrome 3a11 (Cyp3a11) gen and myogenin protein. (-)-Epicatechin interacts and activates PXR, promoting this protein translocation to the nucleus, increasing the expression of Cyp3a11, and promoting C2C12 cell differentiation through increasing myogenin expression. These results can be the base of further studies to analyze the possible participation of PXR in the skeletal muscle effects shown by EC.

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