Pre-Testicular, Testicular, and Post-Testicular Causes of Male Infertility

Dimitriadis, Fotios; Adonakis, George; Kaponis, Apostolos; Mamoulakis, Charalampos; Takenaka, Atsushi; Sofikitis, Nikolaos

doi:10.1007/978-3-319-29456-8_33-2

Cited by 5 publications

(4 citation statements)

References 299 publications

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“…Male-factor infertility is the sole contributor to 20–30% of all infertility cases [ 2 ]. Regardless of the known etiologic factors causing male infertility, such as genetic and chromosomal disorders, testis descent disorders, and post-infection factors, approximately 50% of the cases of male infertility are categorized as idiopathic [ 3 ]. Oxidative stress (OS) is a process associated with the etiology of male infertility.…”

Section: Introductionmentioning

confidence: 99%

Local and Systemic Oxidative Stress Biomarkers for Male Infertility: The ORION Study

Bergsma

Eliveld

et al. 2022

Antioxidants

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Infertility problems occur in around 10% of all couples worldwide, with male-factor infertility as the sole contributor in 20–30% of these cases. Oxidative stress (OS) is suggested to be associated with the pathophysiology of male infertility. In spermatozoa, OS can lead to damage to the cell membrane, resulting in disruption of DNA integrity and a decrease in motility. Established biomarkers for OS include free thiols and malondialdehyde (MDA), both representing different components of the reactive species interactome (RSI). This exploratory study aimed to investigate seminal plasma-free thiol and MDA levels in relation to semen parameters as defined by the World Health Organization (WHO) to determine if these markers are adequate to define local OS status. Furthermore, this study investigated if there is a relation between systemic and local OS status by comparing seminal concentrations of free thiol (R-SH, sulfhydryl groups, representing the extracellular redox status) and MDA (lipid peroxidation product) levels to those measured in serum. Free thiol and MDA measurements in both serum and semen plasma were performed in 50 males (18–55 y) of couples seeking fertility treatment. A significant positive correlation was found between seminal plasma-free thiol levels and sperm concentration and progressive motility (r = 0.383, p = 0.008 and r = 0.333, p = 0.022, respectively). In addition, a significant positive correlation was found between MDA levels in seminal plasma and sperm concentration (r = 0.314, p = 0.031). This study supports that seminal plasma-free thiols may be promising as local OS biomarkers. No associations were observed between local and systemic OS biomarker concentrations.

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Section: Introductionmentioning

confidence: 99%

Local and Systemic Oxidative Stress Biomarkers for Male Infertility: The ORION Study

Bergsma

Eliveld

et al. 2022

Antioxidants

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“…Regarding post-testicular defects, acquired or congenital obstruction arising from the epididymis, vas deferens, or ejaculatory duct can be the basis of obstructive azoospermia, present in about 40% of men with azoospermia [76]. By contrast with testicular damages, post-testicular abnormalities are treatable, and it is often possible to restore the fertility potential.…”

Section: Causes Of Male Infertilitymentioning

confidence: 99%

Semen rheology and its relation to male infertility

et al. 2022

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Infertility affects 15% of couples of reproductive age worldwide. In spite of many advances in understanding and treating male infertility, there is still a number of issues that need further investigation and translation to the clinic. Here, we review the current knowledge and practice concerning semen rheology and its relation with pathological states affecting male infertility. Although it is well recognized that altered rheological properties of semen can impair normal sperm movement in the female reproductive tract, routine semen analysis is mostly focused on number, motility and morphology of spermatozoa, and includes only an approximate, operator-dependent measure of semen viscosity. The latter is based on the possible formation of a liquid thread from a pipette where a semen sample has been aspirated, a method that is sensitive not only to viscosity but also to elongational properties and surface tension of semen. The formation of a liquid thread is usually associated with a gel-like consistency of the sample and changes in spermatozoa motility in such a complex medium are still to be fully elucidated. The aim of this review is to point out that a more quantitative and reliable characterization of semen rheology is in order to improve the current methods of semen analysis and to develop additional tools for the diagnosis and treatment of male infertility.

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“…Disorders of the male reproductive system are typically caused by low testosterone levels, which can lead to various symptoms such as decreased libido, infertility, and muscle loss (Lee & Tillman, 2016). Approximately 7% of men are affected by infertility, which can result from factors acting at different levels of the reproductive system (Dimitriadis, 2017).…”

Section: Introductionmentioning

confidence: 99%

Restorative effect of <i>Annona muricataextract</i> on histomorphology of testicular tissue of cadmium tumor induced albino rats

Ehiremen,

Iyare,

Omorodion

2024

JOHASAM

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Cadmium is a harmful heavy metal that is widely distributed in the environment. This study aimed to investigate the effects of Annona muricata seed extract on cadmium-induced testicular toxicity in adult male Wistar rats. A total of 35 adult male Wistar rats were randomly divided into five groups (A–E)) of 7 rats each. Group A (the control group) received distilled water only; group B-E received 2 mg/kg of cadmium (S.C.) and 100 mg/kg body weight of Annona muricata, 2 mg/kg of cadmium (S.C.) and 200 mg/kg body weight of Annona muricata, and 2 mg/kg of cadmium and 300 mg/kg body weight of Annona muricata respectively. After 17 days of treatment, the animals were brought out, weighed, and sacrificed via cranial dislocation. Testicular, seminal fluid, and blood samples were taken for examination. SPSS version 21 was used in the analysis. The results of the study showed that the Annona muricata aqueous seed extract increased the levels of superoxide dismutase (SOD) and catalase (CAT) in a dose-dependent manner compared to the cadmium-only group. The relative weight of the testis increased significantly in the treated groups compared to the cadmium-only group. Testosterone levels also increased significantly (P < 0.05) in the treated groups compared to the group A (control). The extract showed a significant protective effect against cadmium-induced toxicity, as indicated by the higher testosterone levels in treated groups compared to the untreated group. Medicinal plants like Annona muricata can be used to treat heavy metal toxicity in traditional medicine.

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Pre-Testicular, Testicular, and Post-Testicular Causes of Male Infertility

Cited by 5 publications

References 299 publications

Local and Systemic Oxidative Stress Biomarkers for Male Infertility: The ORION Study

Local and Systemic Oxidative Stress Biomarkers for Male Infertility: The ORION Study

Semen rheology and its relation to male infertility

Restorative effect of <i>Annona muricataextract</i> on histomorphology of testicular tissue of cadmium tumor induced albino rats

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