Pre-Synaptic Control by Histamine H3 Receptors of Neurotransmitter Release

Osorio-Espinoza, Angélica; Ramos-Jiménez, Judith; Arias‐Montaño, José‐Antonio

doi:10.1007/978-90-481-9349-3_15

Cited by 4 publications

(4 citation statements)

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“…In several areas of the rat brain such as cerebral cortex, hippocampus, cerebellum and olfactory bulb, presynaptic H 3 Rs regulate noradrenaline release (Feuerstein, 2008;Osorio-Espinoza et al, 2010;Panula and Nuutinen, 2013;Aquino-Miranda et al, 2012). The NAcc receives noradrenergic projections (Sesack and Grace, 2010), and the inhibition of DOPA accumulation reported herein could have occurred thus in noradrenergic nerve terminals endowed with H 3 Rs.…”

Section: Inhibition By H 3 R Activation Of Dopa Accumulationmentioning

confidence: 78%

Histamine H3 receptor activation inhibits dopamine synthesis but not release or uptake in rat nucleus accumbens

et al. 2016

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Section: Inhibition By H 3 R Activation Of Dopa Accumulationmentioning

confidence: 78%

Histamine H3 receptor activation inhibits dopamine synthesis but not release or uptake in rat nucleus accumbens

et al. 2016

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“…Higher levels of glutamate have been found in plasma and in saliva samples in migraine patients when compared with healthy controls (Tajti et al ., ), and trigeminal nociceptive fibres release the vasoactive neuropeptides, substance P, CGRP and neurokinin A (Cutrer, ). Pre‐synaptic H 3 receptors reduce substance P and neurokinin release from sensory nerve endings as well as glutamate release in several areas of the rat brain (see Feuerstein, and Osorio‐Espinoza et al ., ). Thus, the reduced efficacy of the mutant hH 3 receptor reported herein may be also related to a diminished inhibitory action of endogenous histamine on the release of glutamate and neuroactive peptides, leading to increased susceptibility to migraine attacks.…”

Section: Discussionmentioning

confidence: 97%

A single‐point mutation (Ala280Val) in the third intracellular loop alters the signalling properties of the human histamine H₃ receptor stably expressed in CHO‐K1 cells

Flores-Clemente¹,

Osorio-Espinoza²,

Escamilla-Sánchez³

et al. 2013

British J Pharmacology

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BACKGROUND AND PURPOSEAn alanine to valine exchange at amino acid position 280 (A280V) in the third intracellular loop of the human histamine H3 receptor was first identified in a patient suffering from Shy-Drager syndrome and later reported as a risk factor for migraine. Here, we have compared the pharmacological and signalling properties of wild-type (hH3RWT) and A280V mutant (hH3RA280V) receptors stably expressed in CHO-K1 cells. EXPERIMENTAL APPROACHThe hH3RA280V cDNA was created by overlapping extension PCR amplification. Receptor expression and affinity were assessed by radioligand (N-α-[methyl- KEY RESULTSBoth receptors were expressed at similar levels with no significant differences in their affinities for H3 receptor ligands. Upon activation the hH3RWT was significantly more efficacious to inhibit forskolin-induced cAMP accumulation and to stimulate [ 35 S]-GTPγS binding, with no difference in pEC50 estimates. The hH3RWT was also more efficacious to stimulate ERK1/2 phosphorylation, but this difference was not significant. The inverse agonist ciproxifan was more efficacious at hH3RWT to reduce [ 35 S]-GTPγS binding but, for both receptors, failed to enhance forskolin-induced cAMP accumulation. CONCLUSIONS AND IMPLICATIONSThe A280V mutation reduces the signalling efficacy of the human H3 receptor. This effect may be relevant to the pathophysiology of disorders associated with the mutation.

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“…γ‐Aminobutyric acid (GABA) is a chief endogenous inhibitory neurotransmitter in the central nervous system , and its effects include sedating nerves, promoting resistance to anxiety and detoxification . GABA is also directly responsible for the regulating of muscle tone .…”

Section: Introductionmentioning

confidence: 99%

HPLC determination of γ‐aminobutyric acid and its analogs in human serum using precolumn fluorescence labeling with 4‐(carbazole‐9‐yl)‐benzyl chloroformate

You

Sun

et al. 2019

J of Separation Science

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In this study, a simple analytical method for the determination of γ‐aminobutyric acid, gabapentin, and baclofen by using high‐performance liquid chromatography with fluorescence detection was developed. An amidogen‐reactive fluorescence labeling reagent, 4‐(carbazole‐9‐yl)‐benzyl chloroformate was first used to sensitively label these analytes. The completed labeling of these analytes can be finished rapidly only within 5 min at the room temperature (25°C) to form 4‐(carbazole‐9‐yl)‐benzyl chloroformate labeled fluorescence derivatives. These labeled derivatives expressed strong fluorescence property with the maximum excitation and emission wavelengths of 280 and 380 nm, respectively. The labeled derivatives were analyzed using a reversed‐phase Eclipse SB‐C18 column within 10 min with satisfactory shapes. Excellent linearity (R2 > 0.995) for all analytes was achieved with the limits of detection and the limits of quantitation in the range of 0.25−0.35 and 0.70−1.10 μg/L, respectively. The proposed method was used for the simultaneous determination of γ‐aminobutyric acid and its analogs in human serum with satisfactory recoveries in the range of 94.5–97.5%.

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Pre-Synaptic Control by Histamine H3 Receptors of Neurotransmitter Release

Cited by 4 publications

References 104 publications

Histamine H3 receptor activation inhibits dopamine synthesis but not release or uptake in rat nucleus accumbens

Histamine H3 receptor activation inhibits dopamine synthesis but not release or uptake in rat nucleus accumbens

A single‐point mutation (Ala280Val) in the third intracellular loop alters the signalling properties of the human histamine H₃ receptor stably expressed in CHO‐K1 cells

HPLC determination of γ‐aminobutyric acid and its analogs in human serum using precolumn fluorescence labeling with 4‐(carbazole‐9‐yl)‐benzyl chloroformate

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Pre-Synaptic Control by Histamine H3 Receptors of Neurotransmitter Release

Cited by 4 publications

References 104 publications

Histamine H3 receptor activation inhibits dopamine synthesis but not release or uptake in rat nucleus accumbens

Histamine H3 receptor activation inhibits dopamine synthesis but not release or uptake in rat nucleus accumbens

A single‐point mutation (Ala280Val) in the third intracellular loop alters the signalling properties of the human histamine H3 receptor stably expressed in CHO‐K1 cells

HPLC determination of γ‐aminobutyric acid and its analogs in human serum using precolumn fluorescence labeling with 4‐(carbazole‐9‐yl)‐benzyl chloroformate

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A single‐point mutation (Ala280Val) in the third intracellular loop alters the signalling properties of the human histamine H₃ receptor stably expressed in CHO‐K1 cells