Pre-Radiotherapy (RT) treatment planning factors to take into account in oncologic patients with Inflammatory Bowel Diseases (IBD)

Tolia, Maria; Zygogianni, Anna; Kyrgias, G.; Theodorou, K.; Kappas, Constantin; Kouvaris, John; Kouloulias, Vasileios

doi:10.1016/j.ejmp.2014.07.323

Cited by 1 publication

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“…The two main clinical manifestations are Crohn's disease (CD) and ulcerative colitis (UC). The immune pathogenesis of IBD involves the immune system's interaction with environmental, genetic, vitamin D, and microbial factors (1)(2)(3)(4). Mitochondrial stress-induced mitophagy plays an anti-inflammatory role in IBD (5,6); Paneth cell abnormalities have been associated with defective mitophagy and autophagy in murine intestinal cells (7); Mitophagy also influences intestinal epithelial cell (IEC) viability (8).…”

Section: Introductionmentioning

confidence: 99%

Parkin increases the risk of colitis by downregulation of VDR via autophagy-lysosome degradation

Ma¹,

Wu²,

Wu³

et al. 2023

Int. J. Biol. Sci.

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Parkin, an E3 ubiquitin ligase, plays an essential role in mitophagy. Emerging evidence indicates that mitophagy is involved in various processes closely related to immune diseases, including inflammatory bowel diseases (IBD). Here, the authors show that Parkin increases the occurrence of colitis and severe inflammation. Deletion of Parkin resulted in marked reductions in colonic inflammation and exhibited high resistance to DSS-induced colitis. Mechanism investigation indicated that Parkin interacts with Vitamin D receptors (VDR), a critical inhibitory regulator in IBD. Parkin promotes VDR degradation via the p62-related autophagy-lysosome pathway. Comparison of colitis in Parkin-/- and Parkin-/-Vdr-/- mice showed that the protective effect of Parkin deletion against colitis was abolished by VDR deletion. The result suggests that the regulatory effect of Parkin in colitis is a VDR-dependent pathway. Our research provides a new role of Parkin in colitis by downregulating VDR, which provides a potential strategy for treating IBD.

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