Pre-Pulse Inhibition of an escape response in adult fruit fly, Drosophila melanogaster
Zoltan Asztalos,
Erika Viragh,
Lenke Asztalos
et al.
Abstract:Pre-Pulse Inhibition (PPI) is a neural process where suppression of a startle response is elicited by preceding the startling stimulus (Pulse) with a weak, non-startling one (Pre-Pulse). Defective PPI is widely employed as a behavioural endophenotype in humans and mammalian disorder-relevant models for neuropsychiatric disorders. We have developed a user-friendly, semi-automated, high-throughput-compatible Drosophila light-off jump response PPI paradigm, with which we demonstrate that PPI, with similar paramet… Show more
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