“…There is strong support today for the role of non‐HLA genes in celiac disease. A small controversial effect of the CTLA‐4 gene, which encodes a molecule involved in T‐cell inhibition, has been reported (47–51). Evidence exists for a strong linkage at 5p31–33 (52–54) and also, albeit to a lesser degree, at 19p13.1 (55), 9p 21 (55), and 11q (53, 56).…”