Pre‐operative psychosis following oral lorazepam

Sinha, Prabhat Kumar; Ambesh, Sushil P.

doi:10.1046/j.1365-2044.2003.03415_17.x

Cited by 2 publications

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“…Lorazepam produced significantly more drowsiness than diazepam in the morning of operation day, which was beneficial for induction of anaesthesia and preparation for regional block. Previous studies by Sinha also supports this finding but the greater degree of somnolence and significantly impaired psychomotor function after operation was not advantageous in minor surgical procedures where early discharge after operation is preferred 5,8,12 .…”

Section: Discussionmentioning

confidence: 54%

“…Pharmacodynamically the benzodiazepines are qualitatively identical and the differences between them are due to differences in affinity (potency) and to their different pharmacokinetic properties. The success of the benzodiazepines as therapeutic agents, accompanied by the virtual disappearance of the barbiturates, is due to their efficacy as anxiolytic, hypnotic and anticonvulsant, together with their flat log dose-response curve, which gives a much greater safety margin 3,7,8 .…”

Section: Discussionmentioning

confidence: 99%

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Lorazepam As Anxiolytic Sedative Night Before Operation

Karim¹,

Hossain

et al. 2012

J. Armed Forces Med. Coll.

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Introduction: Surgical patients have a high incidence of anxiety and there is a significant inverse relationship between anxiety and smoothness in induction of anaesthesia. The benzodiazepines are very effective at melting away the active terror of anxiety. Diazepam, a long acting benzodiazepine, is widely used by the anaesthesiologist to allay anxiety and provide sedation. The metabolism of diazepam is slow and is depressed by many factors such as old age, disease states (e.g. hepatic cirrhosis) and concomitant drug administration (e.g. cimetidine). Lorazepam, an intermediate acting benzodiazepine, is well absorbed orally. It is conjugated in the liver to the pharmacologically inactive glucuronide and its metabolism is less impaired by the above factors. Objective: To compare the anxiolytic properties of lorazepam with diazepam before elective surgical procedures. Method: One hundred patients of American Society of Anaesthesiologists (ASA) grade I and grade II, who were scheduled for general surgical, gynaecological operative procedures under general and regional anaesthesia in Combined Military Hospital, Saidpur Cantonment, during the period between June 2008 to June 2010, were included in this study. They were randomly distributed into two groups. Subjects of group A (n=50) received diazepam (Sedil) orally in a dose of 5 mg for <30 kg body weight or 10 mg for 30-70 kg body weight or 15 mg for >70 kg body weight. Subjects of group B (n=50) received lorazepam (Ativan) orally in a dose of 2 mg for <30 kg body weight or 4 mg for 30-70 kg body weight or 6 mg for >70 kg body weight. The effects of the two drugs as anxiolytic sedatives were compared on the basis of haemodynamic parameters, side effects and quality of sleep. Results: There was no significant change in haemodynamic parameters between the two groups. Drugs on group B (Lorazepam group) were found to be more anxiolytic than drugs on group A (Diazepam group). Twenty percent of patients in diazepam group complained of moderate anxiety but it was absent in lorazepam group (p<0.01). Six percent of patients were restless/agitated in preoperative period in diazepam group, but it was absent in lorazepam group. Percentage of tranquil patients was significantly higher in lorazepam group (44%) than that in diazepam group (30%). Hangover effect was noted markedly in group B patients (44%) which was nil in group A patients (p<0.01), but it was beneficial for induction of anaesthesia. Moreover this hangover effect was significantly higher (p<0.01) in female population (50%) than in male population (21.05%). Some other side effects like nausea, vertigo were also noticed in patients of both groups and females were more susceptible to these side effects than males which might be an individual variation. Conclusion: Considering all the factors, lorazepam appeared to be a better option than diazepam as anxiolytic sedative night before operation. DOI: http://dx.doi.org/10.3329/jafmc.v7i2.10392 JAFMC 2011; 7(2): 25-28

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Section: Discussionmentioning

confidence: 54%

Section: Discussionmentioning

confidence: 99%

Lorazepam As Anxiolytic Sedative Night Before Operation

Karim¹,

Hossain

et al. 2012

J. Armed Forces Med. Coll.

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Current awareness: Pharmacoepidemiology and drug safety

2004

Pharmacoepidemiology and Drug

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In order to keep subscribers up‐to‐date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of pharmacoepidemiology and drug safety. Each bibliography is divided into 19 sections: 1 Books, Reviews & Symposia; 2 General; 3 Anti‐infective Agents; 4 Cardiovascular System Agents; 5 CNS Depressive Agents; 6 Non‐steroidal Anti‐inflammatory Agents; 7 CNS Agents; 8 Anti‐neoplastic Agents; 9 Haematological Agents; 10 Neuroregulator‐Blocking Agents; 11 Dermatological Agents; 12 Immunosuppressive Agents; 13 Autonomic Agents; 14 Respiratory System Agents; 15 Neuromuscular Agents; 16 Reproductive System Agents; 17 Gastrointestinal System Agents; 18 Anti‐inflammatory Agents ‐ Steroidal; 19 Others. Within each section, articles are listed in alphabetical order with respect to author. If, in the preceding period, no publications are located relevant to any one of these headings, that section will be omitted.

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Pre‐operative psychosis following oral lorazepam

Cited by 2 publications

References 1 publication

Lorazepam As Anxiolytic Sedative Night Before Operation

Lorazepam As Anxiolytic Sedative Night Before Operation

Current awareness: Pharmacoepidemiology and drug safety

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