Pre-operative DTI and probabilisitic tractography in four patients with deep brain stimulation for chronic pain

Owen, Sarah; Heath, Jennifer; Kringelbach, Morten L.; Green, A.L.; Pereira, Erlick A. C.; Jenkinson, Ned; Jegan, T.; Stein, John; Aziz, Tipu Z.

doi:10.1016/j.jocn.2007.06.010

Cited by 39 publications

(29 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Total PAG connectivity to the cortical and subcortical target regions was consistent with other diffusion MRI studies [Hadjipavlou et al, 2006; Owen et al, 2007, 2008; Pereira et al, 2010; Sillery et al, 2005]. Connectivity to the anterior division of the cingulate gyrus and paracingulate gyrus failed to reach the threshold, despite strong connectivity being demonstrated in animal tracer studies [An et al, 1998].…”

Section: Discussionsupporting

confidence: 82%

Connectivity‐based segmentation of the periaqueductal gray matter in human with brainstem optimized diffusion MRI

Ezra

Faull

Jbabdi

et al. 2015

Human Brain Mapping

View full text Add to dashboard Cite

The periaqueductal gray matter (PAG) is a midbrain structure, involved in key homeostatic neurobiological functions, such as pain modulation and cardiorespiratory control. Animal research has identified four subdivisional columns that differ in both connectivity and function. Until now these findings have not been replicated in humans. This study used high‐resolution brainstem optimized diffusion magnetic resonance imaging and probabilistic tractography to segment the human PAG into four subdivisions, based on voxel connectivity profiles. We identified four distinct subdivisions demonstrating high spatial concordance with the columns of the animal model. The resolution of these subdivisions for individual subjects permitted detailed examination of their structural connectivity without the requirement of an a priori starting location. Interestingly patterns of forebrain connectivity appear to be different to those found in nonhuman studies, whereas midbrain and hindbrain connectivity appears to be maintained. Although there are similarities in the columnar structure of the PAG subdivisions between humans and nonhuman animals, there appears to be different patterns of cortical connectivity. This suggests that the functional organization of the PAG may be different between species, and as a consequence, functional studies in nonhumans may not be directly translatable to humans. This highlights the need for focused functional studies in humans. Hum Brain Mapp 36:3459–3471, 2015. © 2015 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc.

show abstract

Section: Discussionsupporting

confidence: 82%

Connectivity‐based segmentation of the periaqueductal gray matter in human with brainstem optimized diffusion MRI

Ezra

Faull

Jbabdi

et al. 2015

Human Brain Mapping

View full text Add to dashboard Cite

show abstract

“…37,38 Preoperative DTI in the neurosurgical setting has been suggested as a marker of individual organization within the thalamus. 39 We conclude that better understanding of the correspondence between DTI-based and cytoarchitectural subdivisions would require validation studies with consecutive postmortem DTI imaging and histology.…”

Section: Discussionmentioning

confidence: 87%

Generation of Individualized Thalamus Target Maps by Using Statistical Shape Models and Thalamocortical Tractography

Jakab

Blanc

Berényi

et al. 2012

AJNR Am J Neuroradiol

View full text Add to dashboard Cite

show abstract

“…Current investigations are directed towards correlating PAVG DBS electrode location with clinical outcome by the patient's affected body part to assess if somatotopic electrode placement influences efficacy. Further studies in high-resolution diffusion tensor imaging may provide additional evidence for the proposed homunculus orientation [38,39]. Nevertheless, by using invasive neurophysiology to demonstrate the first in vivo objective evidence of a rostrocaudally inverted homunculus in man, the data provide an important addition to our anatomical knowledge of the midbrain.…”

Section: Discussionmentioning

confidence: 99%

Human Periventricular Grey Somatosensory Evoked Potentials Suggest Rostrocaudally Inverted Somatotopy

Pereira

Wang

Owen

et al. 2013

Stereotact Funct Neurosurg

View full text Add to dashboard Cite

Background: Somatosensory homunculi have been demonstrated in primary somatosensory cortex and ventral posterior thalamus but not periaqueductal and periventricular grey matter (PAVG), a therapeutic target for deep brain stimulation (DBS) in chronic pain. Aims: The study is an investigation of somatotopic representation in PAVG and assessment for a somatosensory homunculus. Methods: Five human subjects were investigated using electrical somatosensory stimulation and deep brain macroelectrode recording. DBS were implanted in the contralateral PAVG. Cutaneous arm, leg and face regions were stimulated while event-related potentials were recorded from deep brain electrodes. Electrode contact positions were mapped using MRI and brain atlas information. Results: Monopolar P1 somatosensory evoked potential amplitudes were highest and onset latencies shortest in contralateral caudal PAVG with facial stimulation and rostral with leg stimulation, in agreement with reported subjective sensation during intra-operative electrode advancement. Conclusions: A rostrocaudally inverted somatosensory homunculus exists in the human PAVG region. Objective human evidence of PAVG somatotopy increases understanding of a brainstem region important to pain and autonomic control that is a clinical target for both pharmacological and neurosurgical therapies. Such knowledge may assist DBS target localisation for neuropathic pain syndromes related to particular body regions like brachial plexopathies, anaesthesia dolorosa and phantom limb pain.

show abstract

Pre-operative DTI and probabilisitic tractography in four patients with deep brain stimulation for chronic pain

Cited by 39 publications

References 15 publications

Connectivity‐based segmentation of the periaqueductal gray matter in human with brainstem optimized diffusion MRI

Connectivity‐based segmentation of the periaqueductal gray matter in human with brainstem optimized diffusion MRI

Generation of Individualized Thalamus Target Maps by Using Statistical Shape Models and Thalamocortical Tractography

Human Periventricular Grey Somatosensory Evoked Potentials Suggest Rostrocaudally Inverted Somatotopy

Contact Info

Product

Resources

About