Pre-operative administration of butorphanol mitigates emergence agitation in patients undergoing functional endoscopic sinus surgery: A randomized controlled clinical trial

Zhang, Xiao; Qi, Siyi; Lin, Zhifang; Zhang, Yizhe; Dai, Wei; Tian, Weitian; Tian, Jie; Li, Zheng; Su, Diansan; Huai, Xiaorong

doi:10.3389/fpsyt.2022.1090149

Cited by 3 publications

(3 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Here, an initial dose of butorphanol 6-10 µg/kg/h was used, which is lower than the recommended dose of 10-20 µg/kg/h in previous studies [16]. Our results demonstrated that a lower dose of butorphanol can provide a similar analgesic effect to that of morphine [17], while reducing the risk of nausea, respiratory depression, and drowsiness.…”

Section: Discussionmentioning

confidence: 61%

Safety and Efficacy of Butorphanol as an Analgesic for Patients on Mechanical Ventilation after Cardiac Surgery: An Exploratory Prospective Observational Study

Huang,

Xiang,

Luo

et al. 2024

HSF

View full text Add to dashboard Cite

Purpose: This study assessed the safety and analgesic efficacy of butorphanol in patients receiving mechanical ventilation after cardiac surgery. Methods: This was a prospective study. A consecutive cohort of patients from our medical center who underwent cardiac surgery followed by mechanical ventilation between January 2021 and April 2022 were divided into two groups and received either butorphanol or morphine for analgesia, and all patients also received propofol for sedation. Statistical analysis was performed using the t-test or chi-square test, and the pain levels of the two groups were compared based on the Critical-Care Pain Observation Tool (CPOT), as well as sedation based on the Richmond Agitation-Sedation Scale (RASS), and incidences of adverse events. Results: The two groups, each of which contained 70 patients, reported similar analgesic efficacy; the CPOT score was almost 0 and the RASS score was between 0 and –3. The butorphanol group experienced significantly lower rates of nausea, respiratory depression, and drowsiness. However, the two groups experienced similar rates of vomiting, pruritus, drowsiness, constipation, and delirium, durations of mechanical ventilation, use of sedative drugs, and lengths of stay in the intensive care unit. Conclusions: For patients on mechanical ventilation after cardiac surgery, butorphanol can provide analgesic effects similar to those of morphine with a potentially lower risk of certain adverse events.

show abstract

Section: Discussionmentioning

confidence: 61%

Safety and Efficacy of Butorphanol as an Analgesic for Patients on Mechanical Ventilation after Cardiac Surgery: An Exploratory Prospective Observational Study

Huang,

Xiang,

Luo

et al. 2024

HSF

View full text Add to dashboard Cite

show abstract

“…This stability in MAP is consistent with existing literature highlighting effectiveness of beta blockers in maintaining intra-op hemodynamic stability. 18 Notably, heart rate differences were significant, especially post-medication and intraoperatively. The bisoprolol group exhibited a higher heart rate, averaging 92.47 bpm±5.8 post-medication and 93.77 bpm±5.8 intra-operatively, compared to the placebo group's 63.41 bpm±4.8 and 62.16 bpm±4.3, respectively.…”

Section: Discussionmentioning

confidence: 97%

Effect of preoperative oral bisoprolol on intraoperative outcomes in endoscopic sinus surgery

Alim,

Islam,

Bhoumik

et al. 2024

Int J Res Med Sci

View full text Add to dashboard Cite

Background: Endoscopic sinus surgery (ESS) presents challenges in managing intraoperative bleeding and hemodynamic stability. This study evaluates the efficacy of pre-operative oral bisoprolol in improving surgical conditions and outcomes in ESS. Methods: This study was conducted between March 2021 and June 2022 at the department of anaesthesia, Bangabandhu Sheikh Mujib medical University, Dhaka, Bangladesh. This randomized controlled trial was conducted with 50 participants undergoing elective ESS, divided into bisoprolol and placebo groups. Result: The study involved 50 participants undergoing elective ESS, with 25 in the bisoprolol group and 25 in the placebo group. While demographic characteristics, such as age, weight, height, and gender distribution, showed no statistically significant differences between the groups. The placebo group experienced significantly higher estimated blood loss (421.72 ml vs. 156.24 ml, p<0.001) and postoperative hemoglobin levels (12.88 g/dl vs. 11.07 g/dl, p<0.001) compared to the bisoprolol group. Hemodynamic parameters, particularly heart rate, exhibited significant differences at various time points, with the bisoprolol group maintaining a higher heart rate post-premedication, intra-operatively, and post-operatively (p<0.05 for all). In the assessment of intraoperative bleeding using the Fromme-Boezaart scale, the placebo group demonstrated higher incidences of severe bleeding grades (3 and 4) compared to the bisoprolol group, with these differences being statistically significant (p<0.001). Conclusions: Pre-operative oral bisoprolol in ESS patients significantly reduces intraoperative bleeding and anesthetic requirements while maintaining hemodynamic stability. These findings suggest bisoprolol as a beneficial pre-operative medication in ESS, warranting further research to optimize surgical outcomes.

show abstract

“…[18][19][20][21] In addition, butorphanol has also been proven to mitigate emergence agitation and reduce postoperative shivering. 22,23 Clinical practice concerning pair-wise combinations of butorphanol with ketorolac or dexmedetomidine via patient controlled intravenous analgesia (PCIA) has been well-established recently, while the beneficial characteristic and related side effects of butorphanol in combination with ketorolac and dexmedetomidine together in postoperative multimodal analgesic strategies remain to be verified in large clinical practice. 24 This retrospective study aims to investigate the efficacy and safety of butorphanol combined with dexmedetomidine and ketorolac in multimodal analgesia after hepatobiliary surgery as compared with sufentanil.…”

Section: Introductionmentioning

confidence: 99%

Application of Butorphanol versus Sufentanil in Multimode Analgesia via Patient Controlled Intravenous Analgesia After Hepatobiliary Surgery: A Retrospective Cohort Study

Xu,

Tao,

Yang

et al. 2023

DDDT

View full text Add to dashboard Cite

Purpose We investigate the efficacy and safety of butorphanol in multimodal analgesia combined with dexmedetomidine and ketorolac via patient-controlled intravenous analgesia (PCIA) after hepatobiliary surgery, as compared with sufentanil. Patients and Methods Postoperative follow-up data of hepatobiliary surgery patients in Henan Provincial People’s Hospital from March 2018 to June 2021 were collected retrospectively and divided into butorphanol group (group B) or sufentanil group (group S) according to the postoperative intravenous controlled analgesia scheme. The baseline characteristics and surgical information of the two groups were matched through propensity score matching (PSM). Results A total of 3437 patients were screened, and PSM yielded 1816 patients after matching, including 908 in the butorphanol group and 908 in the sufentanil group. Compared with group S, the incidence of moderate-to-severe pain on the first postoperative day and the second postoperative day was lower in group B during rest (3.2% vs 10.9%, P <0.001; 1.2% vs 4.6%, P <0.001), and during movement (7.0% vs 18.9%, P <0.001; 2.6% vs 8.7%, P <0.001). Patients receiving butorphanol had a lower morphine consumption (50mg vs 120mg, P <0.001). The bolus attempts of an analgesic pump in group B were significantly lower than in group S (1 vs 2, P <0.001). Postoperative hospital length of stay was shortened in group B (11d vs 12d, P =0.017). The occurrence of postoperative vomiting was lower in group B (1.4% vs 3.0%, P =0.025) than in group S. However, more patients in group B experienced dizziness (0.9% vs 0.1%, P =0.019). Conclusion Compared with sufentanil, the application of butorphanol in multimodal analgesia combined with dexmedetomidine and ketorolac via PCIA ameliorated postoperative pain after hepatobiliary surgery, with reduced opioid consumption and shorter postoperative hospital length of stay.

show abstract

Pre-operative administration of butorphanol mitigates emergence agitation in patients undergoing functional endoscopic sinus surgery: A randomized controlled clinical trial

Cited by 3 publications

References 31 publications

Safety and Efficacy of Butorphanol as an Analgesic for Patients on Mechanical Ventilation after Cardiac Surgery: An Exploratory Prospective Observational Study

Safety and Efficacy of Butorphanol as an Analgesic for Patients on Mechanical Ventilation after Cardiac Surgery: An Exploratory Prospective Observational Study

Effect of preoperative oral bisoprolol on intraoperative outcomes in endoscopic sinus surgery

Application of Butorphanol versus Sufentanil in Multimode Analgesia via Patient Controlled Intravenous Analgesia After Hepatobiliary Surgery: A Retrospective Cohort Study

Contact Info

Product

Resources

About