Pre-morbid characteristics and co-morbidity of methamphetamine users with and without psychosis

Chen, C K; Lin, Shih‐Ku; Sham, Pak C.; Ball, David; Loh, El Wui; Hsiao, Chih‐Cheng; Chiang, Yuan‐Lin; Ree, Shao‐Chun; Lee, C H; Murray, Robin M.

doi:10.1017/s0033291703008353

Cited by 245 publications

(249 citation statements)

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“…These findings reinforce the DSM 5 substance-induced psychosis criteria of hallucinations and delusions (American Psychiatric Association, 2013), and they are consistent with past research in showing that delusions in methamphetamine psychosis are primarily persecutory in nature (Akiyama, 2006;Chen et al, 2003;Dore and Sweeting, 2006;Harris and Batki, 2000;Iwanami et al, 1994;Srisurapanont et al, 2003). The affective accompaniment to this psychosis (dominated by depression, suicidality, hostility and self-neglect) is not recognized in the diagnostic criteria for substance-induced psychosis (American Psychiatric Association, 2013) but our results are consistent with Srisurapanont et al (2011), who also found an affective symptom dimension, and other research showing elevated levels of depression among people diagnosed with methamphetamine psychosis relative to other users of the drug (Chen et al, 2003;Lecomte et al, 2013).…”

Section: Discussionsupporting

confidence: 87%

“…The affective accompaniment to this psychosis (dominated by depression, suicidality, hostility and self-neglect) is not recognized in the diagnostic criteria for substance-induced psychosis (American Psychiatric Association, 2013) but our results are consistent with Srisurapanont et al (2011), who also found an affective symptom dimension, and other research showing elevated levels of depression among people diagnosed with methamphetamine psychosis relative to other users of the drug (Chen et al, 2003;Lecomte et al, 2013). These collective findings suggest that affective symptoms may be a core feature of the methamphetamine psychosis, perhaps similar to depression with psychotic features or schizoaffective disorder (Tsuang et al, 1982).…”

Section: Discussionsupporting

confidence: 87%

“…Consistent with these criteria, most studies have noted the prominence of hallucinations and delusions, which are usually persecutory in nature (Akiyama, 2006;Angrist et al, 1974;Angrist and Gershon, 1970;Chen et al, 2003;Connell, 1966;Dore and Sweeting, 2006;Harris and Batki, 2000;Iwanami et al, 1994;Janowsky and Risch, 1979;Mahoney et al, 2008;Medhus et al, 2013;Srisurapanont et al, 2003). However, they fail to distinguish between methamphetamine-induced psychosis and schizophrenia on the remaining symptoms of schizophrenia (Hides et al, 2015;Medhus et al, 2013;Srisurapanont et al, 2003Srisurapanont et al, , 2011, disorganized speech (e.g., frequent derailment or incoherence), grossly disorganized or catatonic behavior, and negative symptoms (e.g., diminished emotional expression or avolition; American Psychiatric Association, 2013).…”

Section: Introductionmentioning

confidence: 92%

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The profile of psychiatric symptoms exacerbated by methamphetamine use

McKetin

Dawe

Burns

et al. 2016

Drug and Alcohol Dependence

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Methods: 164 methamphetamine users, who did not meet DSM-IV criteria for a lifetime primary psychotic disorder, were followed monthly for one year to assess the relationship between days of methamphetamine use and symptom severity on the 24-item Brief Psychiatric Rating Scale.Exacerbation of psychiatric symptoms with methamphetamine use was quantified using random coefficient models. The dimensions of symptom exacerbation were examined using principal axis factoring and a latent profile analysis. Results:Symptoms exacerbated by methamphetamine loaded on three factors: positive psychotic symptoms (suspiciousness, unusual thought content, hallucinations, bizarre behavior); affective symptoms (depression, suicidality, guilt, hostility, somatic concern, self-neglect); and psychomotor symptoms (tension, excitement, distractibility, motor hyperactivity). Methamphetamine use did not significantly increase negative symptoms. Vulnerability to positive psychotic and affective symptom exacerbation was shared by 28% of participants, and this vulnerability aligned with a past year DSM-IV diagnosis of substance-induced psychosis (38% vs. 22%, χ 2 (df 1) = 3.66, p = 0.056). Conclusion:Methamphetamine use produced a symptom profile comprised of positive psychotic and affective symptoms, which aligned with a diagnosis of substance-induced psychosis, with no evidence of a negative syndrome.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionsupporting

confidence: 87%

Section: Introductionmentioning

confidence: 92%

See 1 more Smart Citation

The profile of psychiatric symptoms exacerbated by methamphetamine use

McKetin

Dawe

Burns

et al. 2016

Drug and Alcohol Dependence

View full text Add to dashboard Cite

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“…The original purpose of CKC's study was to investigate the predisposing factors to methamphetamineinduced psychosis and the results demonstrate that subjects with methamphetamine-induced psychosis may be classified as a distinct group from methamphetamine users. 39 Details of the sampling method and exclusion criteria are mentioned in their work. As the size of the methamphetamine-induced psychosis sample is rather small at this status and may have a different genetic background, here we only examined methamphetamine users without psychosis and the controls.…”

Section: Subjectsmentioning

confidence: 99%

Gender-specific contribution of the GABAA subunit genes on 5q33 in methamphetamine use disorder

et al. 2003

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Family and twins studies have suggested that genetic factors are involved in the development of substance use disorders. Several unrelated case/control association studies have reported associations of the GABA A subunit genes on 5q33 with the development of alcohol dependence. We hypothesized that these particular GABA A subunit genes also contribute to the development of methamphetamine use disorder. To test our hypothesis, we recruited cases using a series of questionnaires. Among the polymorphic SNPs, significant differences between cases and controls were identified in the female sample in the rs2279020 of the GABA A a1 subunit gene, and the novel SNP rs4480617 in the GABA A g2 subunit gene. No associations were found in the male sample. Further haplotype analysis identified several marker blocks significantly associated with methamphetamine use disorder in females; each block consists of the rs4480617. Our study provides preliminary evidence that the GABA A subunit genes on 5q33 may preferentially contribute to methamphetamine use disorder in females. There is increasing evidence that substance use disorders are familial and that genetic factors explain a substantial degree of the familial aggregation. 3 Grove et al 4 studied a sample of 32 pairs of monozygotic twins reared apart, and reported that inherited factors explained 45% of the variance in drug abuse and dependence. Pickens et al 5 found that the variance attributable to genetic factors in abuse of illicit drugs is 31% in males and 22% in females. Similarly, Tsuang et al 6 reported that genetic factors account for 34% of the variance in the individual's risk of developing a drug use disorder; for stimulant abuse, 44% of the variance is attributable to genetic factors. The pairwise concordance rate for stimulant abuse was 14.1% for monozygotic twins and 5.3% for dizygotic twins. 7 The supporting evidence is also derived from animal studies. For example, knockout of the dopamine D4 receptor gene in mice result in animals that are supersensitive to several substances, including methamphetamine. 8 For the GABA A a1 knockout mice, administration of amphetamine sulfate caused an

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“…Drug users in Taiwan typically have high morbidity of physical and mental illnesses, 15,16 but have little access to mental health services. 16,17 For example, of 325 methamphetamine abusers at a detention center in Taipei, only 8.9% had seen a mental health professional and only 3.1% had been admitted to a psychiatric facility, despite 36.6% reporting that they experienced mental disturbances and 24.3% reporting that they experienced occupational impairment. 16 The majority of these drug abusers did not reveal their use to professionals.…”

Section: Introductionmentioning

confidence: 99%

Recidivism among male subjects incarcerated for illicit drug use in Taiwan

Chiang

Chan

Chen

et al. 2006

Psychiatry Clin Neurosci

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Illicit drug users are generally considered both patients and criminals in Taiwan. This study presents drug use behaviors and criminal recidivism of male subjects incarcerated for illicit drug use in Taiwan after detoxification at a detention center. This study also examined the relationship between drug use behaviors and subsequent recidivism. Charts and crime records of 794 male patients from the acute detoxification unit in a detention center in northern Taiwan were reviewed. These subjects were incarcerated for methamphetamine or/and heroin use. The authors examined the relationship between the variables collected during detoxification and subsequent recidivism of illicit drug use in the following 5 years after detoxification. Of 794 subjects, 539 (67.9%) were repeat offenders during the following 5 years after detoxification. Their recidivism occurred primarily within the first 2 years after being released into the community. The recidivism rate for heroin users was significantly higher than that of methamphetamine users. Aged under 30 years, a previous criminal record, and a positive urine analyses test for illicit drugs upon entering the detoxification unit were significantly associated with recidivism. Recidivism rates of illicit drug users in Taiwan after detoxification in the detention center were substantially high. The efficacy of detoxification programs at detention centers in Taiwan needs to be re-evaluated.

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Pre-morbid characteristics and co-morbidity of methamphetamine users with and without psychosis

Cited by 245 publications

References 25 publications

The profile of psychiatric symptoms exacerbated by methamphetamine use

The profile of psychiatric symptoms exacerbated by methamphetamine use

Gender-specific contribution of the GABAA subunit genes on 5q33 in methamphetamine use disorder

Recidivism among male subjects incarcerated for illicit drug use in Taiwan

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