Pre-Menopausal Breast Fat Density Might Predict MACE During 10 Years of Follow-Up

Sardu, Celestino; Gatta, Gianluca; Pieretti, Gorizio; Viola, Luigi; Sacra, Cosimo; Grezia, Graziella Di; Musto, Lanfranco; Minelli, Salvatore; Forgia, Daniele La; Capodieci, Mariangela; Galiano, Alessandro; Vestito, Angela; Lisio, Angela De; Pafundi, Pia Clara; Sasso, Ferdinando Carlo; Cappabianca, Salvatore; Nicoletti, Gianfranco; Paolisso, Giuseppe; Marfella, Raffaele

doi:10.1016/j.jcmg.2020.08.028

Cited by 42 publications

(39 citation statements)

References 24 publications

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“…Besides, age is also a factor influencing the efficacy of hormone replacement therapy for postmenopausal women [ 21 ]. Recently published 10-year follow-up results of the BRECARD Study [ 22 ] indicated that the higher the content of breast adipose tissue, the higher the incidence of MACE in pre-menopausal women. In addition to the traditional risk factors, adipokines may play an important role in atherosclerosis process in elder people [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

Particles and corrected particles of LDL and non-HDL are stronger predicters of coronary lesion in postmenopausal women

Chen

Wei

et al. 2021

BMC Cardiovasc Disord

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Background The optimum lipid indexes, predicting the coronary lesion in postmenopausal women are not clear. Objective To evaluate the optimum lipid predicter for coronary lesion in routine and advanced lipid tests. Method 300 postmenopausal women were enrolled and assigned into coronary heart disease (CHD) Group (242), and non-CHD Group (58). Routine and advanced lipid indexes were measured with standard laboratory test and nuclear magnetic resonance (NMR) spectroscopy. The correlation and predictivities for CHD of routine and advanced lipid indexes were performed with Logistic regression, Spearman correlation analysis and receiver operating characteristic (ROC). Results Age (hazard ratio (HR) 2.58, 95% confidence interval (CI) 1.08–5.86, P = 0.03), apolipoprotein B (ApoB) (HR 1.35, 95% CI 1.15–1.59, P < 0.001), corrected particles of low-density lipoprotein (LDL-p-corr) (HR 1.05, 95% CI 1.03–1.06, P < 0.001) and corrected particles of non-high-density lipoprotein (non-HDL-p-corr) (HR 1.02, 95% CI 1.01–1.03, P < 0.001) were the risk factors of CHD. LDL cholesterol (LDL-C), LDL-p, LDL-p-corr, HDL cholesterol (HDL-C), non-HDL cholesterol (non-HDL-C), non-HDL-p and non-HDL-p-corr were in linear correlation with Gensini score. Advanced lipid indexes LDL-p (area under curve (AUC) = 0.750, P = 0.02), LDL-p-corr (AUC = 0.759, P = 0.02), non-HDL-p (AUC = 0.693, P = 0.03) and non-HDL-p-corr (AUC = 0.699, P = 0.03) were more predictive for CHD than the routine ones (LDL-C and non-HDL-C). Conclusion In postmenopausal women, age, ApoB, LDL-p-corr and non-HDL-p-corr were risk factors of CHD. Compared with traditional lipid items, LDL-p, LDL-p-corr, non-HDL-p and non-HDL-p-corr may be better lipid indexes for CHD in postmenopausal women.

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Section: Discussionmentioning

confidence: 99%

Particles and corrected particles of LDL and non-HDL are stronger predicters of coronary lesion in postmenopausal women

Chen

Wei

et al. 2021

BMC Cardiovasc Disord

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“…The MACE were defined as a composite end point indicating cardiovascular disease events, hospital admissions for heart failure and ischemic cardiovascular events. The cardiovascular disease events were diagnosed by evidence of ischemic heart disease, peripheral arterial disease, stroke/transitory ischemic attack, or revascularization procedure (10,12). Finally, the study investigators reported all the events with the potential to be adjudicated as one of the predefined study end points, regardless of the opinion of the investigator (12).…”

Section: Major Adverse Cardiac Events Definitionmentioning

confidence: 99%

“…The cardiovascular disease events were diagnosed by evidence of ischemic heart disease, peripheral arterial disease, stroke/transitory ischemic attack, or revascularization procedure (10,12). Finally, the study investigators reported all the events with the potential to be adjudicated as one of the predefined study end points, regardless of the opinion of the investigator (12). In the case of identification of a suspected unreported event by a reviewer, authors asked to the reviewer to make a note back to the investigator (12).…”

Section: Major Adverse Cardiac Events Definitionmentioning

confidence: 99%

“…Finally, the study investigators reported all the events with the potential to be adjudicated as one of the predefined study end points, regardless of the opinion of the investigator (12). In the case of identification of a suspected unreported event by a reviewer, authors asked to the reviewer to make a note back to the investigator (12). Thereafter, MACE were collected during patients' interview, visits, and by hospital discharge schedules (12).…”

Section: Major Adverse Cardiac Events Definitionmentioning

confidence: 99%

“…In the case of identification of a suspected unreported event by a reviewer, authors asked to the reviewer to make a note back to the investigator (12). Thereafter, MACE were collected during patients' interview, visits, and by hospital discharge schedules (12).…”

Section: Major Adverse Cardiac Events Definitionmentioning

confidence: 99%

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Atherosclerotic Plaque Fissuration and Clinical Outcomes in Pre-Diabetics vs. Normoglycemics Patients Affected by Asymptomatic Significant Carotid Artery Stenosis at 2 Years of Follow-Up: Role of MIcRoRNAs Modulation. The ATIMIR Study

Sardu¹,

Modugno²,

Castellano³

et al. 2021

Preprint

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BACKGROUND AND PURPOSE—Atherosclerotic plaque instability and rupture in patients with asymptomatic carotid artery stenosis (ACAS) is a leading cause of major adverse cardiac events (MACE). This could be mainly evidenced in patients with pre-diabetes. Indeed, the altered glucose homeostasis and insulin resistance could cause over-inflammation of atherosclerotic plaque, favoring its conversion to unstable phenotype with rupture and MACE. Notably, the metformin therapy reducing the metabolic distress and the inflammatory burden, could lead to reduction of MACE in ACAS patients with pre-diabetes. In this setting, microRNAs (miRs) could be used as molecular biomarkers of atherosclerosis progression, plaque rupture and worse prognosis in normoglycemics (NG) vs. pre-diabetics metformin users (PDMU) vs. pre-diabetics non metformin users (PDNMU). However, the aim of our study was to investigate a wide miRNA panel in peripheral blood exosomes from patients with ACAS divided in NG vs. PDMU vs. PDNMU, and to associate the circulating miRNA expression profiles with MACE at 2 years of follow-up after endarterectomy. METHODS—The study included 234 patients with ACAS divided in NG (n 125), PDNMU (n 73) and PDMU (n 36). The miRs’ expression profiles of circulating exosomes were determined at baseline and at 2 years of follow-up by Affymetrix microarrays from plasma samples of the patients from any study cohort. Then we collected and analyzed MACE at 2 years of follow-up in NG vs. PDMU vs. PDNMU. RESULTS—prediabetics vs. NG had over-inflammation (p<0.05) and over expressed miR 24 and miR 27 at baseline. At 2 years of follow-up PDNMU vs. NG, PDMU vs. NG and PDNMU vs. PDMU over-expressed inflammatory markers and miR 24, miR 27, miR 100, miR 126 and miR 133 (p<0.05). Finally, at follow-up end we observed a significant difference about MACE comparing PDNMU vs. NG (n 27 (36.9%) vs. n 8 (6.4%); p<0.05), PDNMU vs. PDMU (n 27 (36.9%) vs. n 6 (16.6%); p <0.05), and PDMU vs. NG (n 6 (16.6%) vs. n 8 (6.4%); p<0.05). Admission glucose values (HR 1.020, CI 95% [1.001-1.038], p 0.029), atheromatous carotid plaque (HR 5.373, CI 95% [1.251-11.079], p 0.024), and miR 24 (HR 3.842, CI 95% [1.768-19.222], p 0.011) predicted MACE at 2 years of follow-up. CONCLUSIONS—Specific circulating miRs could be over-expressed in pre-diabetics and specifically in PDNMU vs. PDMU after endarterectomy. MiR24, hyperglycemia and atheromatous plaque could predict MACE at 2 years of follow-up.

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The association between breast arterial calcification and atherosclerotic cardiovascular disease in an Australian population-based breast cancer case–control study

et al. 2023

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Purpose Atherosclerotic cardiovascular disease (ASCVD) is a major cause of morbidity and mortality. Breast arterial calcification (BAC) on mammograms is not associated with breast cancer risk. However, there is increasing evidence supporting its association with cardiovascular disease (CVD). This study examines the association between BAC and ASCVD and their risk factors within an Australian population-based breast cancer study. Materials and methods Data from the controls who participated in the breast cancer environment and employment study (BCEES) were linked with the Western Australian Department of Health Hospital Morbidity database and Mortality Registry to obtain ASCVD outcomes and related risk factor data. Mammograms from participants with no prior history of ASCVD were assessed for BAC by a radiologist. Cox proportional hazards regression was used to examine the association between BAC and later occurrence of an ASCVD event. Logistic regression was used to investigate the factors associated with BAC. Results A total of 1020 women with a mean age of 60 (sd = 7.0 years) were included and BAC found in 184 (18.0%). Eighty (7.8%) of the 1020 participants developed ASCVD, with an average time to event of 6.2 years (sd = 4.6) from baseline. In univariate analysis, participants with BAC were more likely to have an ASCVD event (HR = 1.96 95% CI 1.29–2.99). However, after adjusting for other risk factors, this association attenuated (HR = 1.37 95% CI 0.88–2.14). Increasing age (OR = 1.15, 95% CI 1.12–1.19) and parity (pLRT < 0.001) were associated with BAC. Conclusion BAC is associated with increased ASCVD risk, but this is not independent of cardiovascular risk factors.

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Pre-Menopausal Breast Fat Density Might Predict MACE During 10 Years of Follow-Up

Cited by 42 publications

References 24 publications

Particles and corrected particles of LDL and non-HDL are stronger predicters of coronary lesion in postmenopausal women

Particles and corrected particles of LDL and non-HDL are stronger predicters of coronary lesion in postmenopausal women

Atherosclerotic Plaque Fissuration and Clinical Outcomes in Pre-Diabetics vs. Normoglycemics Patients Affected by Asymptomatic Significant Carotid Artery Stenosis at 2 Years of Follow-Up: Role of MIcRoRNAs Modulation. The ATIMIR Study

The association between breast arterial calcification and atherosclerotic cardiovascular disease in an Australian population-based breast cancer case–control study

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