2012
DOI: 10.1590/s0004-282x2012000800010
|View full text |Cite
|
Sign up to set email alerts
|

Pre, intra and post-ischemic hypothermic neuroprotection in temporary focal cerebral ischemia in rats: morphometric analysis

Abstract: Objective: To evaluate the neuroprotection of mild hypothermia, applied in different moments, in temporary focal cerebral ischemia in rats. Methods: Rats was divided into Control (C), Sham (S), Ischemic-control(IC), Pre-ischemic Hypothermia (IH1), Intra-ischemic Hypothermia (IH2), and Post-ischemic Hypothermia (IH3) groups. Morphometry was performed using the KS400 software (Carl Zeiss IH3 and IH1 vs. IH2 (p=0.57; p=0.79). Conclusion: Pre-ischemic and intra-ischemic hypothermia were shown to be similarly neur… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
2

Citation Types

0
5
0
1

Year Published

2015
2015
2016
2016

Publication Types

Select...
5
1

Relationship

0
6

Authors

Journals

citations
Cited by 7 publications
(6 citation statements)
references
References 25 publications
(45 reference statements)
0
5
0
1
Order By: Relevance
“…Control ischemic group (n = 8) that submitted to 60 minutes of ischemia [5, 6, 13, 14] and 24 hours of reperfusion and then rats kept for seven days.…”
Section: Methodsmentioning
confidence: 99%
See 3 more Smart Citations
“…Control ischemic group (n = 8) that submitted to 60 minutes of ischemia [5, 6, 13, 14] and 24 hours of reperfusion and then rats kept for seven days.…”
Section: Methodsmentioning
confidence: 99%
“…Post-ischemic hypothermia (33.5-35°C) [5] was initiated at the time of reperfusion for 30 minutes, and then rats kept for seven days.…”
Section: Methodsmentioning
confidence: 99%
See 2 more Smart Citations
“…However, recent experimental and clinical studies have demonstrated that mild hypothermia is useful for neuroprotection [6,7] and the treatment of cerebral edema [8,9] after acute brain injury, including brain trauma, ischemic stroke, and ICH. Mild hypothermia may reduce cerebral metabolism, decrease levels of excitatory amino acids, stabilize the blood-brain barrier, and account for membrane stabilization [10][11][12]. In mild hypothermia, systemic mild hypothermia is difficult to achieve in clinical practice due to its potential adverse effects, including pneumonia, shivering, and metabolic derangements [8,9], local mild hypothermia can achieve target temperature quickly, and overcome possible adverse effects [13], thus, its efficacy is superior to systemic mild hypothermia in neuroprotective therapies.…”
Section: Introductionmentioning
confidence: 99%