Pre-gelatinized cassava starch orally disintegrating films: Influence of β-Cyclodextrin

Sha, Haojie; Yuan, Chao; Cui, Bo; Zhao, Meng; Wang, Jialin

doi:10.1016/j.foodhyd.2021.107196

Cited by 22 publications

(5 citation statements)

References 44 publications

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“…Samples (approx. 3 mg) were heated in a hermetically sealed standard aluminum pan over a temperature range of 40–250 °C at a heating cycle of 20 °C·min −1 under a nitrogen atmosphere [ 30 ].…”

Section: Methodsmentioning

confidence: 99%

Development and Characterizations of Pullulan and Maltodextrin-Based Oral Fast-Dissolving Films Employing a Box–Behnken Experimental Design

et al. 2022

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Migraine is a neurological disorder characterized by severe headaches, visual aversions, auditory, and olfactory disorders, accompanied by nausea and vomiting. Zolmitriptan (ZMT®) is a potent 5HT1B/1D serotonin receptor agonist frequently used for the treatment of migraine. It has erratic absorption from the gastrointestinal tract (GIT), but its oral bioavailability is low (40–45%) due to the hepatic metabolism. This makes it an ideal candidate for oral fast dissolving formulations. Hence, the current study was undertaken to design and develop oral fast-dissolving films (OFDFs) containing ZMT for migraine treatment. The OFDFs were formulated by the solvent casting method (SCM) using Pullulan (PU) and maltodextrin (MDX) as film-forming agents and propylene glycol (PG) as a plasticizer. The strategy was designed using Box–Behnken experimental design considering the proportion of PU:MDX and percentage of PG as independent variables. The effectiveness of the OFDF’s was measured based on the following responses: drug release at five min, disintegration time (D-time), and tensile strength (TS). The influence of formulation factors, including percent elongation (%E), thickness, water content, moisture absorption, and folding endurance on ZMT-OFDFs, were also studied. The results showed a successful fabrication of stable ZMT-OFDFs, with surface uniformity and amorphous shape of ZMT in fabricated films. The optimized formulation showed a remarkable rapid dissolution, over 90% within the first 5 min, a fast D-time of 18 s, and excellent mechanical characteristics. Improved maximum plasma concentration (C max) and area under the curve (AUC 0–t) in animals (rats) treated with ZMT-OFDFs compared to those treated with an intra-gastric (i-g) suspension of ZMT were also observed. Copolymer OFDFs with ZMT is an exciting proposition with great potential for the treatment of migraine headache. This study offers a promising strategy for developing ZMT-OFDFs using SCM. ZMT-OFDFs showed remarkable rapid dissolution and fast D-time, which might endeavor ZMT-OFDFs as an auspicious alternative approach to improve patient compliance and shorten the onset time of ZMT in migraine treatment.

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Section: Methodsmentioning

confidence: 99%

Development and Characterizations of Pullulan and Maltodextrin-Based Oral Fast-Dissolving Films Employing a Box–Behnken Experimental Design

et al. 2022

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“…The twisted chains between OCD3 and CS might be hindered by the excessive CS, resulting in a smoothness of the complex surface. 43 The surface roughness of the complexes and their shape were also slightly altered at different pH values. The OCD3/ CS-pH 5 exhibited a relatively more uniform surface with lowest R q of 0.24 nm and R a of 0.11 nm, whereas complexes generated at pH 3 and 7 presented considerably greater R q values with magnitudes of 0.44 and 35.04 nm, respectively.…”

Section: ■ Results and Discussionmentioning

confidence: 98%

“…However, the roughness of the complex surface declined when the CS concentration was 1%. The twisted chains between OCD3 and CS might be hindered by the excessive CS, resulting in a smoothness of the complex surface …”

Section: Resultsmentioning

confidence: 99%

Development of Emulsion Gels Stabilized by Chitosan and Octenyl Succinic Anhydride-Modified β-Cyclodextrin Complexes for β-Carotene Digestion and 3D Printing

Li,

Hao,

Gao

2023

J. Agric. Food Chem.

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β-cyclodextrin (β-CD)-based emulsion gels encapsulated with nutrition for three-dimensional (3D) printing are promising, while obstacles such as low bioaccessibility of bioactive compounds and the molding process in food manufacturing hinder their application. This study intended to develop stable composite emulsion gels using the complexes of chitosan (CS) and octenyl succinic anhydride (OSA)-modified β-CD (OCD) to conquer these challenges. The esterification of OSA generated more negatively charged OCD and ester groups, which aided in the combination of OCD and CS through enhanced electrostatic and hydrogen bonding interactions. The addition of CS improved the emulsification properties of the complexes and acted as a bridge link in the aqueous phase, thereby increasing the gel strength of the composite emulsion gels. Moreover, the encapsulation of βcarotene destabilized the strength of the emulsion gels by lowering the interfacial tension. The emulsion gel stabilized by OCD3/CS-0.75% at an initial pH not only successfully encapsulated β-carotene and presented the highest bioaccessibility of 41.88 ± 0.87% in the in vitro digestion but also showed excellent 3D printability. These results provided a promising strategy to enhance the viscoelasticity of β-CD-based emulsion gels and accelerate their application in bioactive compound delivery systems and 3D food printing.

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“…木薯淀粉制作薄膜的制作方法主要有流延法 [234] 、热熔挤出法 [235] 、溶剂浇铸法 [236] 和溶剂置换法 [237] , 所用原料的相关技术主要有共混技术和淀粉改性技术. 混合材料主要包括纤维类(如木薯渣 [236,238] 、蓝莓渣 [239] 、南瓜皮 [240] 、羧甲基纤维素 [241] 、纳米纤维素 [234,242] 等)、天然橡胶 [243] 、蛋白类(发酵乳清 [244] 、明胶 [245,246] 、玉米醇溶蛋白 [247] 、燕麦麸 [240] 等)、土类(如蒙脱土 [248] 、膨润土 [249] 、纳米粘土 [250] 等)、精油类 [251,252] 、多酚 [253,254] 、多糖 [235,246,251] 、纳米粒子 [255][256][257] 和离子液体 [258] 等; 淀粉改性主要涉及化学改性和物理改性, 如交联改性 [259] 、氧化改性 [260] 、酯化改性 [259] 、预糊化 [261] 、辐照改性 [262,263] 、超声改性 [264] 等. 目前, 木薯淀粉膜也在向智能化发展, 如 pH 响应型膜 [257,265] 的开发.…”

Section: 消化特性unclassified

Research progress of starch from characteristic tropical crops

WANG,

ZHANG,

ZHANG

et al. 2024

Sci. Sin.-Vitae

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Starch, the predominant carbohydrate in nature, serves as the primary energy source for various physiological activities in humans. Characteristic starches from tropical crops, such as cassava, banana, jackfruit, and breadfruit, mango, and canistel have gained attention due to their diverse and multiscale structures, distinct physicochemical properties, processing characteristics, and myriad applications. This review provides a comprehensive summary of the research progress on starch from various tropical crops. Specifically, the extraction technology, amylopectin content, multiscale structure, physical and chemical properties, processing technology, and applications of starch are reviewed. The advancements, application prospects, and research suggestions on starch from characteristic tropical crops are also discussed, which provides theoretical guidance for enhancing the processing level of related products and diversifying food sources.

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Pre-gelatinized cassava starch orally disintegrating films: Influence of β-Cyclodextrin

Cited by 22 publications

References 44 publications

Development and Characterizations of Pullulan and Maltodextrin-Based Oral Fast-Dissolving Films Employing a Box–Behnken Experimental Design

Development and Characterizations of Pullulan and Maltodextrin-Based Oral Fast-Dissolving Films Employing a Box–Behnken Experimental Design

Development of Emulsion Gels Stabilized by Chitosan and Octenyl Succinic Anhydride-Modified β-Cyclodextrin Complexes for β-Carotene Digestion and 3D Printing

Research progress of starch from characteristic tropical crops

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