Pre‐fusion motion state determines the heterogeneity of membrane fusion dynamics for large dense‐core vesicles
Renhao Xue,
Enming Zhang,
Yu Wang
Abstract:AimIn neuroendocrine cells, large dense‐core vesicles (LDCVs) undergo highly regulated pre‐fusion processes before releasing hormones via membrane fusion. Significant heterogeneity has been found for LDCV population based on the dynamics of membrane fusion. However, how the pre‐fusion status impacts the heterogeneity of LDCVs still remains unclear. Hence, we explored pre‐fusion determinants of heterogeneous membrane fusion procedure of LDCV subpopulations.MethodsWe assessed the pre‐fusion motion of two LDCV su… Show more
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