Pre-exposure to mRNA-LNP inhibits adaptive immune responses and alters innate immune fitness in an inheritable fashion

Qin, Zhen; Bouteau, Aurélie; Herbst, Christopher; Igyártó, Botond Z.

doi:10.1371/journal.ppat.1010830

Cited by 19 publications

(27 citation statements)

References 72 publications

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“…Indeed, the mRNA vaccine was shown to reprogram both adaptive and innate immunity [ 136 ], thus interfering with natural immune responses. The changes in immunity may be transmitted to the next generations in animal models [ 137 ]. Spike, by binding to its receptor ACE2, can change the catalytic activity of this receptor and enzyme or directly down-regulate the receptor, impeding its functions [ 138 ].…”

Section: Possible Mechanisms Of Covid-19 Mrna Vaccine-induced Tissue/...mentioning

confidence: 99%

Safety of COVID-19 Vaccines in Patients with Autoimmune Diseases, in Patients with Cardiac Issues, and in the Healthy Population

2023

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The coronavirus disease 2019 (COVID-19) has been a challenge for the whole world since the beginning of 2020, and COVID-19 vaccines were considered crucial for disease eradication. Instead of producing classic vaccines, some companies pointed to develop products that mainly function by inducing, into the host, the production of the antigenic protein of SARS-CoV-2 called Spike, injecting an instruction based on RNA or a DNA sequence. Here, we aim to give an overview of the safety profile and the actual known adverse effects of these products in relationship with their mechanism of action. We discuss the use and safety of these products in at-risk people, especially those with autoimmune diseases or with previously reported myocarditis, but also in the general population. We debate the real necessity of administering these products with unclear long-term effects to at-risk people with autoimmune conditions, as well as to healthy people, at the time of omicron variants. This, considering the existence of therapeutic interventions, much more clearly assessed at present compared to the past, and the relatively lower aggressive nature of the new viral variants.

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Section: Possible Mechanisms Of Covid-19 Mrna Vaccine-induced Tissue/...mentioning

confidence: 99%

Safety of COVID-19 Vaccines in Patients with Autoimmune Diseases, in Patients with Cardiac Issues, and in the Healthy Population

2023

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“…cerns can be traced back to as early as 2012, when laboratory mice developed severe pulmonary immunopathology after being vaccinated and then exposed to the SARS coronavirus [3]. A decade later, other mouse data linked the mRNA lipid nanoparticle-based Covid-19 vaccine platform to the phenomena of adaptive immune cell exhaustion and non-responsiveness, both secondary to the chronic stimulation of immune-inflammatory pathways [4].…”

Section: Of 15mentioning

confidence: 99%

Forgotten “Primum Non Nocere” and Increased Mortality after Covid-19 Vaccination

Šorli¹,

Makovec²,

Krevel³

et al. 2023

Preprint

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Background. The main impetus behind the worldwide Covid-19 vaccination campaign in 2021 was to reduce the mortality attributed to SARS-CoV-2 infection in the preceding year. Nevertheless, rigorous analyses of the mortality benefits conferred by this massive vaccination effort have been lacking. Methods Statistics offers us an essential methodological approach for measuring the impacts of Covid-19 vaccination on public health. The mathematical relation between vaccinated-alive groups can be repeated between vaccinated-dead groups with relatively high statistical reliability because of the large population numbers involved. This method also confers greater statistical usefulness because it eliminates the Simpson effect. Results Calculations were performed for each of the following five four-week intervals: weeks 35-38 (2021), weeks 39-42 (2021), weeks 43-46 (2031), weeks 47-50 (2021), and weeks 51(2021)-2(2022). The results obtained confirm that the mortality of the vaccinated coronavirus-infected groups was 14.5% higher on average than the mortality of non-vaccinated coronavirus-infected groups. Conclusions Vaccinated infected groups appear to have higher average mortality than their non-vaccinated infected counterparts. The findings suggest the legitimacy of extending the statistic between vaccinated living and vaccinated dead individuals for different age groups. Calculating the impact of Covid-19 vaccination on the mortality rate is a necessary step toward satisfying the first principle of medicine: “Primum non nocere”, “Do no harm”.

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“…These concerns can be traced back to as early as 2012 when laboratory mice developed severe pulmonary immunopathology after being vaccinated and then exposed to the SARS coronavirus [3]. A decade later, other mouse data linked the mRNA lipid nanoparticle-based Covid-19 vaccine platform to the phenomena of adaptive immune cell exhaustion and non-responsiveness, both secondary to the chronic stimulation of immune-inflammatory pathways [4].…”

Section: Of 23mentioning

confidence: 99%

Forgotten “Primum Non Nocere” and Increased Mortality after Covid-19 Vaccination

Šorli¹,

Makovec²,

Krevel³

et al. 2023

Preprint

View full text Add to dashboard Cite

Background. The main impetus behind the worldwide Covid-19 vaccination campaign in 2021 was to reduce the mortality attributed to SARS-CoV-2 infection in the preceding year. Nevertheless, rigorous analyses of the mortality benefits conferred by this massive vaccination effort have been lacking. Methods Statistics offers us an essential methodological approach for measuring the impacts of Covid-19 vaccination on public health. The mathematical relation between vaccinated-alive groups can be repeated between vaccinated-dead groups with relatively high statistical reliability because of the large population numbers involved. This method also confers greater statistical usefulness because it eliminates the Simpson effect. Results Calculations were performed for each of the following five(5) four-week intervals: weeks 35-38 (2021), weeks 39-42 (2021), weeks 43-46 (2021), weeks 47-50 (2021), and weeks 51(2021)-2(2022). The results obtained confirm that the mortality of the vaccinated coronavirus-infected groups was 14.5% higher on average than the mortality of non-vaccinated coronavirus-infected groups. Conclusions Vaccinated infected groups appear to have higher average mortality than their non-vaccinated infected counterparts. The findings suggest the legitimacy of extending the statistics between vaccinated living and vaccinated dead individuals for different age groups. Calculating the impact of Covid-19 vaccination on the mortality rate is a necessary step towards satisfying the first principle of medicine: “Primum non nocere”, “Do no harm”.

show abstract

Pre-exposure to mRNA-LNP inhibits adaptive immune responses and alters innate immune fitness in an inheritable fashion

Cited by 19 publications

References 72 publications

Safety of COVID-19 Vaccines in Patients with Autoimmune Diseases, in Patients with Cardiac Issues, and in the Healthy Population

Safety of COVID-19 Vaccines in Patients with Autoimmune Diseases, in Patients with Cardiac Issues, and in the Healthy Population

<strong></strong>Forgotten “Primum Non Nocere” and Increased Mortality after Covid-19 Vaccination <strong> </strong>

<strong></strong>Forgotten “Primum Non Nocere” and Increased Mortality after Covid-19 Vaccination <strong> </strong>

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