“…The potential advantages include strong immune responses, capacity for large gene inserts, genetic stability and good expression of the constructs, and the availability of various strains. Among the potential disadvantages are preexisting immunity in the population because of widespread viral infection or immunization campaigns, immunogenicity of vector itself, and the pathogenic and tumorigenic potential of viruses with a doublestranded DNA genome [5,6]. In addition, it is sometimes impossible to find a proper balance between attenuation, immunogenicity, and growth properties of a viral vector, as was demonstrated in preclinical studies of engineered vectored vaccines based on vesicular stomatitis virus [7].…”