Pre-Eclampsia: One Name, Two Conditions – The Case for Early and Late Disease Being Different

Valensise, H.; Novelli, G. P.; Vasapollo, B.

doi:10.1017/s0965539513000016

Cited by 2 publications

(2 citation statements)

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“…The exact mechanisms of these interactions are not clear; however, it is postulated that varying the influence of both factors can produce two separate phenotypes of preeclampsia: an early-onset phenotype, which is associated with poor placentation and foetal growth restriction, and a lateonset phenotype, which is not thought to be related to placental causes [27,28].…”

Section: Pre-eclampsiamentioning

confidence: 99%

Hypertension in Pregnancy: Natural History and Treatment Options

et al. 2015

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Hypertensive disorders of pregnancy affect approximately 5-10% of all maternities and are major contributors of maternal and neonatal morbidity and mortality worldwide. This group of disorders encompasses chronic hypertension, as well as conditions that arise de novo in pregnancy: gestational hypertension and pre-eclampsia. The latter group is thought to be part of the same continuum but with arbitrary division. Research into the aetiology of hypertension in pregnancy have largely been focused on pre-eclampsia, with a majority of studies exploring either pregnancy-associated factors such as placental-derived or immunologic responses to pregnancy tissue, or maternal constitutional factors such as cardiovascular health and endothelial dysfunction. The evidence base for the pathophysiology and progression of hypertensive disorders in pregnancy, particularly pre-eclampsia, is reviewed. Clinical algorithms and pharmacological agents for the management of hypertension in pregnancy are summarised, with a brief focus on post-partum considerations and long-term health implications. Novel therapeutic options for the management of pre-eclampsia are also explored.

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Section: Pre-eclampsiamentioning

confidence: 99%

Hypertension in Pregnancy: Natural History and Treatment Options

et al. 2015

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“…También se ha descrito diferencias hemodinámicas, encontrando en la PIP aumento de la resistencia periférica, con respuesta baja del gasto cardiaco, y en la PIT, resistencia periférica disminuida con gasto cardiaco aumentado, en lo que algunos investigadores denominan la fase latente de la preeclampsia (15,16) .…”

Section: Las Diferencias Clínicasunclassified

Preeclampsia de inicio temprano y tar dío: una antigua enfermedad, nuevas ideas

Paredes

Romero

2015

Rev peru ginecol obstet.

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Las importantes diferencias que existen entre las manifestaciones de la preeclampsia, antes(inicio temprano) y después de la semana 34 (inicio tardío), plantean la posibilidad quese trate de dos enfermedades distintas. Basada en diferencias genéticas, epidemiológicasy placentarias, esta hipótesis cobra fuerza. Sin embargo, recientes estudios nos muestranla posibilidad de una continuidad clínico temporal entre ambos fenotipos. En este contextolos fenómenos antiangiogénicos y su relación con el feto podrían ser determinantes paraesclarecer la interrogante.Palabras clave: Preeclampsia de inicio temprano, preeclampsia de inicio tardío, desbalanceantiangiogénico.

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Pre-Eclampsia: One Name, Two Conditions – The Case for Early and Late Disease Being Different

Cited by 2 publications

References 32 publications

Hypertension in Pregnancy: Natural History and Treatment Options

Hypertension in Pregnancy: Natural History and Treatment Options

Preeclampsia de inicio temprano y tar dío: una antigua enfermedad, nuevas ideas

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