Pre-eclampsia has an adverse impact on maternal and fetal health

Lin, Saunders; Leonard, Dean; Co, Mary Antonette M.; Mukhopadhyay, Dhriti; Giri, Badri; Perger, Lena; Beeram, Madhava R.; Kuehl, Thomas J.; Uddin, Mohammad Nasir

doi:10.1016/j.trsl.2014.10.006

Cited by 58 publications

(61 citation statements)

References 137 publications

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“…Evidence for other pleiotropic links related to fitness included 25 genes that shared links with traits expressed during pregnancy (S4 and S5 Tables), i.e. variation that can negatively influence the health and survival outcomes of both the fetus and mother [66]. For example, a variant of CDKN2B-AS1 significantly contributes to risk of fetal growth restriction [67], both FLT1 [68] and LPL [69] are significantly differentially expressed in placental tissues from pregnancies with intrauterine growth restriction (IUGR), and preeclampsia and LDLR-deficient mice had litters with significant IUGR [70].…”

Section: Enrichment Of Cad Loci For Lifetime Reproductive Outcomes Anmentioning

confidence: 99%

Genetic loci associated with coronary artery disease harbor evidence of selection and antagonistic pleiotropy

Byars

Huang

Gray

et al. 2016

Preprint

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Traditional genome-wide scans for positive selection have mainly uncovered selective sweeps associated with monogenic traits. While selection on quantitative traits is much more common, very few signals have been detected because of their polygenic nature. We searched for positive selection signals underlying coronary artery disease (CAD) in worldwide populations, using novel approaches to quantify relationships between polygenic selection signals and CAD genetic risk. We identified new candidate adaptive loci that appear to have been directly modified by disease pressures given their significant associations with CAD genetic risk. These candidates were all uniquely and consistently associated with many different male and female reproductive traits suggesting selection may have also targeted these because of their direct effects on fitness. We found that CAD loci are significantly enriched for lifetime reproductive success relative to the rest of the human genome, with evidence that the relationship between CAD and lifetime reproductive success is antagonistic. This supports the presence of antagonistic-pleiotropic tradeoffs on CAD loci and provides a novel explanation for the maintenance and high prevalence of CAD in modern humans. Lastly, we found that positive selection more often targeted CAD gene regulatory variants using HapMap3 lymphoblastoid cell lines, which further highlights the unique biological significance of candidate adaptive loci underlying CAD. Our study provides a novel approach for detecting selection on polygenic traits and evidence that modern human genomes have evolved in response to CAD-induced selection pressures and other early-life traits sharing pleiotropic links with CAD.

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Section: Enrichment Of Cad Loci For Lifetime Reproductive Outcomes Anmentioning

confidence: 99%

Genetic loci associated with coronary artery disease harbor evidence of selection and antagonistic pleiotropy

Byars

Huang

Gray

et al. 2016

Preprint

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“…Preeclampsia is a clinical multisystem disorder with different phenotypes that begins after 20 weeks of gestation, and can evolve to eclampsia with life threatening brain damage [1,2], unique to humans [3]. Nowadays preeclampsia still lacks an etiology, early prediction and/or diagnosis and effective treatment.…”

Section: Preeclampsia In the 21st Century: Unresolved Questions Concementioning

confidence: 99%

Preeclampsia in the 21st century: Unresolved questions concerning etiology

Pluta¹,

Ułamek-Kozioł²,

Furmaga-Jabłońska³

et al. 2015

Nutrition

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ABSTRACT

Background: Pregnancy-induced hypertension (PIH) is still a major cause of maternal and infant morbidity and mortality worldwide.

…”

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“…Berdasarkan berat lahir, preeklamsia berat memiliki pengaruh yang bermakna secara statistik terhadap BBLSR (OR=11,45;38; OR penyesuaian=8,68; 95% CI=1,04) dan BBLR (OR=6,57; 95% CI=4,[1][2][3][4][5][6][7][8][9][10]79; OR penyesuaian=5,71; 95% CI=3,78 …”

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“…Genetic factors are at least partially responsible whether a maternal or a paternal family history of preeclampsia will increase the risk of developing it. 5 Fetal growth consists of several variables, namely birth weight (BW), birth length (BL), and head circumference (HC). It is determined by both duration of gestation and complication from maternal condition, especially preeclampsia.…”

mentioning

confidence: 99%

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Impact of pregnancy-induced hypertension on fetal growth

2016

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ABSTRAK (OR=1,90; 95% CI=1,01; OR penyesuaian=1,91; 95% CI=1,01) dan besar masa kehamilan (OR=2,70; 95% CI=1,(0)(1)(2)(3)(4)(5)(6)(7)29; OR penyesuaian=2,92; 95% CI=1,(7)(8)00). Berdasarkan berat lahir, preeklamsia berat memiliki pengaruh yang bermakna secara statistik terhadap BBLSR (OR=11,45;38; OR penyesuaian=8,68; 95% CI=1,04) dan BBLR (OR=6,57; 95% CI=4,[1][2][3][4][5][6][7][8][9][10]79; OR penyesuaian=5,71; 95% CI=3,78 ABSTRACTBackground: Pregnancy-induced hypertension (PIH) is still a major cause of maternal and infant morbidity and mortality worldwide. The aim of this study to investigate the impact of PIH on fetal growth.

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Pre-eclampsia has an adverse impact on maternal and fetal health

Cited by 58 publications

References 137 publications

Genetic loci associated with coronary artery disease harbor evidence of selection and antagonistic pleiotropy

Genetic loci associated with coronary artery disease harbor evidence of selection and antagonistic pleiotropy

Preeclampsia in the 21st century: Unresolved questions concerning etiology

Impact of pregnancy-induced hypertension on fetal growth

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