Pre-diagnostic serum levels of inflammation markers and risk of ovarian cancer in the Prostate, Lung, Colorectal and Ovarian Cancer (PLCO) Screening Trial

Trabert, Britton; Pinto, Lígia A.; Hartge, Patricia; Kemp, Troy J.; Black, Amanda; Sherman, Mark E.; Brinton, Louise A.; Pfeiffer, Ruth M.; Shiels, Meredith S.; Chaturvedi, Anil K.; Hildesheim, Allan; Wentzensen, Nicolas

doi:10.1016/j.ygyno.2014.08.025

Cited by 86 publications

(70 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Despite the somewhat equivocal evidence on specific dietary components, there is strong evidence suggesting the role of inflammation in the incidence of ovarian cancer (6, 7, 38, 39). In the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, both higher levels of CRP and IL-6 have been shown to be associated with increased risk of ovarian cancer (7).…”

Section: Discussionmentioning

confidence: 99%

Dietary inflammatory index and ovarian cancer risk in a large Italian case–control study

Shivappa

Hébert

Rosato

et al. 2016

Cancer Causes Control

View full text Add to dashboard Cite

Background While inflammation has been shown to play an important etiologic role in ovarian carcinogenesis, little is known about the association between inflammatory properties of diet and ovarian cancer risk. Methods We explored the association between the dietary inflammatory index (DII) and ovarian cancer risk in a multicentric Italian case-control study conducted between 1992 and 1999. Cases were 1031 women with incident, histologically confirmed ovarian cancer from 4 areas in Italy. Controls were 2,411 women admitted to the same network of hospitals as the cases for acute, non-malignant and non-gynecological conditions, unrelated to hormonal or digestive-tract diseases or committed to long-term modifications of diet. DII scores were computed based on 31 nutrients and food items assessed using a reproducible and validated 78-item food frequency questionnaire. Odds ratios (ORs) were estimated through logistic regression models adjusting for age, total energy intake and other recognised confounding factors. Results Subjects in the highest quartile of DII scores (i.e., with the most pro-inflammatory diets) had a higher risk of ovarian cancer compared to subjects in the lowest quartile (i.e., with an anti-inflammatory diet) (ORQuartile4vs1= 1.47, 95% confidence interval, CI, 1.07, 2.01; p-trend=0.009). When analyses were carried out using continuous DII, a significant positive association with ovarian cancer was observed, the OR for one-unit increment in DII score (corresponding to approximately 8% of its range in the current study, +6.0 to −6.20) was 1.08 (95% CI=1.02, 1.14). Conclusion A pro-inflammatory diet as indicated by higher DII scores is associated with increased ovarian cancer risk.

show abstract

Section: Discussionmentioning

confidence: 99%

Dietary inflammatory index and ovarian cancer risk in a large Italian case–control study

Shivappa

Hébert

Rosato

et al. 2016

Cancer Causes Control

View full text Add to dashboard Cite

show abstract

“…Log-transformed ICCs were greater than 0.8 in 91%, 91% and 78% of evaluable markers in the lung, NHL and ovary studies, respectively (29). ICCs below 0.70 were reported for one marker (IL-2) in the lung study (26) and five markers (IFNγ, IL-1RA, PYY, sIL-4R, and sVEGF-2) in the ovarian cancer study (27). Additional information on quality control measurements can be found elsewhere (26–28).…”

Section: Methodsmentioning

confidence: 98%

“…The present cross-sectional investigation includes participants from the screening arm of PLCO who were selected as either cases or controls for one of three previously conducted nested case-control studies of lung cancer (526 cases and 592 controls) (26), ovarian cancer (150 cases and 149 controls) (27) or non-Hodgkin lymphoma (NHL) (301 cases and 301 controls) (28). Participants in the three case-control studies were weighted to the screening-arm of PLCO using weights discussed in the Statistical Analysis section.…”

Section: Methodsmentioning

confidence: 99%

“…Serum samples from the lung cancer and NHL studies were collected at baseline; serum samples from the ovarian cancer study were collected at baseline or at a follow-up visit to ensure a relatively equal distribution of specimens between 2 and 14 years prior to diagnosis (27). All samples were centrifuged at 1,200×g for 15 minutes, frozen within two hours of collection and stored at −70°C.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Associations of Coffee Drinking with Systemic Immune and Inflammatory Markers

Loftfield

Shiels

Graubard

et al. 2015

Cancer Epidemiology, Biomarkers &Amp; Prevention

Self Cite

View full text Add to dashboard Cite

Background Coffee drinking has been inversely associated with mortality as well as cancers of the endometrium, colon, skin, prostate, and liver. Improved insulin sensitivity and reduced inflammation are among the hypothesized mechanisms by which coffee drinking may affect cancer risk; however, associations between coffee drinking and systemic levels of immune and inflammatory markers have not been well characterized. Methods We used Luminex bead-based assays to measure serum levels of 77 immune and inflammatory markers in 1,728 older non-Hispanic Whites. Usual coffee intake was self-reported using a food frequency questionnaire. We used weighted multivariable logistic regression models to examine associations between coffee and dichotomized marker levels. We conducted statistical trend tests by modeling the median value of each coffee category and applied a 20% false discovery rate criterion to P-values. Results Ten of the 77 markers were nominally associated (P-value for trend<0.05) with coffee drinking. Five markers withstood correction for multiple comparisons and included aspects of the host response namely chemotaxis of monocytes/macrophages (IFNγ, CX3CL1/fractalkine, CCL4/MIP-1β), pro-inflammatory cytokines (sTNFRII) and regulators of cell growth (FGF-2). Heavy coffee drinkers had lower circulating levels of IFNγ (OR=0.35; 95% CI 0.16–0.75), CX3CL1/fractalkine (OR=0.25; 95% CI 0.10–0.64), CCL4/MIP-1β (OR=0.48; 95% CI 0.24–0.99), FGF-2 (OR=0.62; 95% CI 0.28–1.38), and sTNFRII (OR=0.34; 95% CI 0.15–0.79) than non-coffee drinkers. Conclusions Lower circulating levels of inflammatory markers among coffee drinkers may partially mediate previously observed associations of coffee with cancer and other chronic diseases. Impact Validation studies, ideally controlled feeding trials, are needed to confirm these associations.

show abstract

“…The mechanisms that link excess adiposity to ovarian cancer are only speculative, but they include systemic and local tissue inflammation. In a prospective analysis from the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial cohort, substantial positive associations were observed between ovarian cancer risk and elevated concentrations of CRP, IL1a, and TNF-a (Trabert et al 2014). Supporting the hypothesis that the hyperinflammatory state of obesity is an important mechanism for ovarian cancer is the observation from a recent metaanalysis of 14 case-control and seven cohort studies that ovarian cancer risk is reduced with frequent aspirin use (Baandrup et al 2013).…”

Section: Ovarian Cancermentioning

confidence: 95%

Body fatness as a cause of cancer: epidemiologic clues to biologic mechanisms

Byers¹,

Sedjo²

2015

Endocrine-Related Cancer

View full text Add to dashboard Cite

Carrying excess body fat is a leading cause of cancer. Epidemiologic evidence gives strong clues about the mechanisms that link excess adiposity to risk for several cancer sites. For postmenopausal breast cancer and endometrial cancer, the hyper-estrogenic state that is induced by excess body fatness is the likely cause. For esophageal cancer and gallbladder cancer, chronic local inflammation induced by acid reflux and gallstones is the likely cause, and for liver cancer, local inflammation induced by hepatic fatty infiltration is the likely cause. However, for several other cancers known to be associated with excess adiposity, including cancers of the colon, pancreas, ovary, kidney, and prostate, specific causes are not known. Possible candidates include elevated systemic or local tissue inflammation induced by adiposity and effects of the elevated levels of leptin, insulin, IGFs, and depressed immune function that are seen with excess adiposity. There is growing evidence that intentional weight loss not only reduces circulating levels of cancer-associated factors but that it also reduces cancer incidence and recurrence. Better research is needed to understand the mechanisms that link excess body fat to cancer risk as well as to understand the amount of weight loss needed for substantial cancer risk reduction. Finally, as we develop better understanding of the mediators of the effects of excess body fatness on cancer risk, we should identify pharmacologic interventions that target those mediators so that they can be used to complement weight loss in order to reduce cancer risk.

show abstract

Pre-diagnostic serum levels of inflammation markers and risk of ovarian cancer in the Prostate, Lung, Colorectal and Ovarian Cancer (PLCO) Screening Trial

Cited by 86 publications

References 47 publications

Dietary inflammatory index and ovarian cancer risk in a large Italian case–control study

Dietary inflammatory index and ovarian cancer risk in a large Italian case–control study

Associations of Coffee Drinking with Systemic Immune and Inflammatory Markers

Body fatness as a cause of cancer: epidemiologic clues to biologic mechanisms

Contact Info

Product

Resources

About