Pre-diagnostic C-reactive protein concentrations, CRP genetic variation and mortality among individuals with colorectal cancer in Western European populations

Nimptsch, Katharina; Aleksandrova, Krasimira; Fedirko, Veronika; Jenab, Mazda; Gunter, Marc J.; Siersema, Peter D.; Wu, Kana; Katzke, Verena; Kaaks, Rudolf; Panico, Salvatore; Palli, Domenico; May, Anne M.; Sieri, Sabina; Bueno‐de‐Mesquita, Bas; Standahl, Karina; Sánchez, María‐José; Pérez-Cornago, Aurora; Olsen, Anja; Tjønneland, Anne; Bonet, Catalina; Dahm, Christina C.; Chirlaque, María‐Dolores; Fiano, Valentina; Tumino, Rosario; Gurrea, Aurelio Barricarte; Boutron‐Ruault, Marie‐Christine; Ménégaux, Florence; Severi, Gianluca; Guelpen, Bethany Van; Lee, Youngae; Pischon, Tobias

doi:10.1186/s12885-022-09778-9

Cited by 8 publications

(8 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To date, the associations between FV intake and in ammatory biomarkers levels including CRP have been suggested [16,44]. Besides, studies also consistently reported that CRP level was associated with premature death from allcause, cardiovascular and cancer [45][46][47][48]. Our ndings provided quantitative evidence supporting the plausible hypothesis that fruit and vegetables intake plays a key role in premature death through reducing in ammatory biomarker CRP level.…”

Section: Discussionsupporting

confidence: 76%

C-reactive protein mediates the association between fruit and vegetable intake, and mortality among US adults

Laouali¹,

Chen²,

Shah³

et al. 2023

Preprint

View full text Add to dashboard Cite

Background Fruit and vegetable (FV) are part of a healthy diet as their consumption has been consistently associated with a reduction in the risk of premature mortality and various biomarkers of inflammation have been hypothesized to partially explain such relationships. However, empirical evidence quantifying the mediating role of such biomarkers in the relationship between FV intake and mortality is not available at the population level. The present study examines the association between FV daily servings or objectively measured biomarkers of FV intake and mortality and the extent to which a biomarker of inflammation mediates these associations. Methods We used data on 13,892 adults aged ≥ 20 years enrolled in the NHANES-III between 1988 and 1994 and followed up through Dec 31, 2015. Daily serving of FV was assessed using 24-hour dietary recall and mortality was determined from the National Death Index records. Serum concentrations of 6 biomarkers of FV intake and C-reactive protein (CRP) were measured in blood samples. We used a causal mediation analysis with Aalen additive hazards models to decompose the total effect of FV intake on mortality into natural direct and indirect (through CRP level) effects while controlling for a priori-defined confounders. We also calculated the proportion mediated. Results Over the follow-up period, 5023 participants died (1503 from cardiovascular diseases, and 1110 from cancer). High daily FV serving (at least 5 servings) and high level of FV biomarker (> median) were associated with a lower risk of death compared to low daily servings and low level of FV intake biomarker, respectively. Comparing participants with high scores to low scores of the FV intake biomarker, we observed reduced hazard rate difference for all-cause (-0.54 per 10000 person-year [95% CI -0.72 to -0.33]), cardiovascular disease (-0.19 per 10000 person-year [95% CI -0.26 to -0.12]), and cancer (-0.10 per 10000 person-year [95% CI -0.14 to -0.06]) mortality that can be attributed to subsequent decreases in CRP. The corresponding proportions mediated were 16%, 17%, and 10% for all-cause, cardiovascular, and cancer mortality, respectively. Conclusion Our findings confirmed the beneficial effects of FV intake and that the effects were partly mediated by a reduction in circulating CRP.

show abstract

Section: Discussionsupporting

confidence: 76%

C-reactive protein mediates the association between fruit and vegetable intake, and mortality among US adults

Laouali¹,

Chen²,

Shah³

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…High resistin levels in the “steady‐state” conditions could be caused by CLGSI, which many conditions may have triggered. Under CLGSI, C‐reactive protein (CRP), an inflammatory marker, was not significantly associated with CRC mortality, as previously reported 34 . Of the conditions that trigger CLGSI, obesity is typical, as inflammation is initially induced in white adipose tissue and extends to other tissues and circulation, resulting in CLGSI 35 .…”

Section: Discussionmentioning

confidence: 54%

“…Under CLGSI, C-reactive protein (CRP), an inflammatory marker, was not significantly associated with CRC mortality, as previously reported. 34 Of the conditions that trigger CLGSI, obesity is typical, as inflammation is initially induced in white adipose tissue and extends to other tissues and circulation, resulting in CLGSI. 35 Pre-diagnostic obesity was reported as a significant factor in the risk of death in patients with non-metastatic CRC.…”

Section: Measurements Of Resistin Concentrations After Crc Diagnosismentioning

confidence: 99%

Pre‐diagnostic circulating resistin concentrations and mortality among individuals with colorectal cancer: Results from the European Prospective Investigation into Cancer and Nutrition study

Pham,

Nimptsch,

Aleksandrova

et al. 2024

Intl Journal of Cancer

View full text Add to dashboard Cite

Resistin is a protein involved in inflammation and angiogenesis processes and may play a role in the progression of colorectal cancer (CRC). However, it remains unclear whether resistin is associated with increased mortality after CRC diagnosis. We examined pre‐diagnostic serum resistin concentrations in relation to CRC‐specific and all‐cause mortality among 1343 incident CRC cases from the European Prospective Investigation into Cancer and Nutrition cohort. For CRC‐specific mortality as the primary outcome, hazard ratios (HRs) and 95% confidence intervals (95% CI) were estimated from competing risk analyses based on cause‐specific Cox proportional hazards models and further in sensitivity analyses using Fine–Gray proportional subdistribution hazards models. For all‐cause mortality as the secondary outcome, Cox proportional hazards models were used. Subgroup analyses were performed by sex, tumor subsite, tumor stage, body mass index and time to CRC diagnosis. Resistin was measured on a median of 4.8 years before CRC diagnosis. During a median follow‐up of 8.2 years, 474 deaths from CRC and 147 deaths from other causes were observed. Resistin concentrations were not associated with CRC‐specific mortality (HRQ4vsQ1 = 0.95, 95% CI: 0.73–1.23; Ptrend = .97; and HRper doubling of resistin concentration = 1.00; 95% CI: 0.84–1.19; P = .98) or all‐cause mortality. Results from competing risk (sensitivity) analysis were similar. No associations were found in any subgroup analyses. These findings suggest no association between pre‐diagnostic circulating resistin concentrations and CRC‐specific or all‐cause mortality among persons with CRC, and the potential insignificance of resistin in CRC progression.

show abstract

“…C-reactive protein (CRP) levels are typically thought of as a biomarker for inflammatory response and not as a pathogenetic factor, although inherited CRP variants have been associated with, and thus possibly a modifying factor in some infections [ 22 , 23 ] response to vaccination, [ 26 ] as well as other conditions such as cancer [ 44 , 45 ] and pre-eclampsia [ 46 , 47 ]. For this reason, we selected 4 available variants related to CRP expression for our analysis.…”

Section: Methodsmentioning

confidence: 99%

Genetic variant rs1205 is associated with COVID-19 outcomes: The Strong Heart Study and Strong Heart Family Study

Best,

Erdei,

Haack

et al. 2024

PLoS ONE

View full text Add to dashboard Cite

Background Although COVID-19 infection has been associated with a number of clinical and environmental risk factors, host genetic variation has also been associated with the incidence and morbidity of infection. The CRP gene codes for a critical component of the innate immune system and CRP variants have been reported associated with infectious disease and vaccination outcomes. We investigated possible associations between COVID-19 outcome and a limited number of candidate gene variants including rs1205. Methodology/Principal findings The Strong Heart and Strong Heart Family studies have accumulated detailed genetic, cardiovascular risk and event data in geographically dispersed American Indian communities since 1988. Genotypic data and 91 COVID-19 adjudicated deaths or hospitalizations from 2/1/20 through 3/1/23 were identified among 3,780 participants in two subsets. Among 21 candidate variants including genes in the interferon response pathway, APOE, TMPRSS2, TLR3, the HLA complex and the ABO blood group, only rs1205, a 3’ untranslated region variant in the CRP gene, showed nominally significant association in T-dominant model analyses (odds ratio 1.859, 95%CI 1.001–3.453, p = 0.049) after adjustment for age, sex, center, body mass index, and a history of cardiovascular disease. Within the younger subset, association with the rs1205 T-Dom genotype was stronger, both in the same adjusted logistic model and in the SOLAR analysis also adjusting for other genetic relatedness. Conclusion A T-dominant genotype of rs1205 in the CRP gene is associated with COVID-19 death or hospitalization, even after adjustment for relevant clinical factors and potential participant relatedness. Additional study of other populations and genetic variants of this gene are warranted.

show abstract

Pre-diagnostic C-reactive protein concentrations, CRP genetic variation and mortality among individuals with colorectal cancer in Western European populations

Cited by 8 publications

References 39 publications

C-reactive protein mediates the association between fruit and vegetable intake, and mortality among US adults

C-reactive protein mediates the association between fruit and vegetable intake, and mortality among US adults

Pre‐diagnostic circulating resistin concentrations and mortality among individuals with colorectal cancer: Results from the European Prospective Investigation into Cancer and Nutrition study

Genetic variant rs1205 is associated with COVID-19 outcomes: The Strong Heart Study and Strong Heart Family Study

Contact Info

Product

Resources

About