Pre-Diabetics with Hypovitaminosis D Have Higher Risk for Insulin Resistance

Nur-Eke, Remziye; Ozen, Mehmet; Çekın, Ayhan Hilmi

doi:10.7754/clin.lab.2018.181014

Cited by 7 publications

(5 citation statements)

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“…Race is another potential confounder 13 . Although a positive association was observed in studies from the USA 3,4 , Kuwait 5 and Turkey 35 , negative results have been reported in studies from India 7 and Brazil 8 . This observation is strengthened by the findings of Shankar et al 4 , which showed an association between vitamin D levels and the incidence of prediabetes among adults in the USA.…”

Section: Discussionmentioning

confidence: 85%

“…However, although female sex might account for the negative association between vitamin D deficiency and prediabetes 6 , it does not explain it fully. Modi et al 7 , in a study of an all-female population, and Nur-Eke et al 35 , in a study of a predominantly (80.4%) female population from Turkey, found a significant negative correlation between levels of vitamin D and HbA1c in individuals with prediabetes.…”

Section: Discussionmentioning

confidence: 95%

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Vitamin D levels, prediabetes risk and hemoglobin A1c levels in young non‐diabetic Saudi women

Al-Mohaissen

Lee

Alamri

2020

J of Diabetes Invest

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Aims/Introduction Vitamin D levels are negatively correlated with prediabetes risk and hemoglobin A1c levels in individuals with prediabetes. The data are, however, scarce and inconsistent among different populations. We aimed to assess the association of vitamin D with prediabetes risk and hemoglobin A1c levels in young Saudi women with normoglycemia and prediabetes. Materials and Methods We analyzed the data of individuals without diabetes (without diabetes history and hemoglobin A1c <6.4%) from the Princess Nourah bint Abdulrahman University’s non‐communicable diseases student registry. Demographic data, anthropometric and blood pressure measurements, and hemoglobin A1c and vitamin D results were retrieved and analyzed. Results In total, 345 participants were included in the analysis. The prediabetes status showed no association with vitamin D levels, but it was significantly associated with the participants’ weight and body mass index. Additionally, there was no correlation between the levels of vitamin D and hemoglobin A1c across the whole population, even after correction for body mass index. However, in the body mass index subgroups, when individuals with potentially harmful levels of vitamin D (>125 nmol/L) were excluded, a positive association was detected between vitamin D and hemoglobin A1c levels in the underweight individuals. Hemoglobin A1c values showed a positive correlation only with bodyweight and body mass index. Conclusions Vitamin D levels did not predict prediabetes status and showed no correlation with hemoglobin A1c levels in this population. Vitamin D levels’ effect on the risk of prediabetes might be small compared with other well‐established risk factors, such as obesity.

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Section: Discussionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 95%

Vitamin D levels, prediabetes risk and hemoglobin A1c levels in young non‐diabetic Saudi women

Al-Mohaissen

Lee

Alamri

2020

J of Diabetes Invest

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“…There is evidence to show that vitamin D therapy improves glucose tolerance and IR (38,39) . There are studies, both in the West and Indian subcontinent, that have reported that vitamin D deficiency is associated with T2DM (11,(40)(41)(42)(43)(44) and prediabetes (10,(44)(45)(46)(47)(48) . The recent Hitachi Health Study (41) conducted in Japanese adults concluded that higher circulating vitamin D was associated with a lower risk of T2DM, and this association was stronger among individuals with prediabetes.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of vitamin D deficiency in urban south Indians with different grades of glucose tolerance

et al. 2020

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The present study assessed the prevalence of vitamin D deficiency in an urban south Indian population in individuals with different grades of glucose tolerance. A total of 1500 individuals (900 normal glucose tolerance (NGT), 300 prediabetes and 300 with type 2 diabetes mellitus (T2DM)) who were not on vitamin D supplementation were randomly selected from the Chennai Urban Rural Epidemiological Study follow-up study. Anthropometric, clinical examination and biochemical investigations (25-hydroxyvitamin D (25(OH)D), insulin, glycated Hb (HbA1c) and serum lipids) were measured. Vitamin D deficiency was defined as serum 25(OH)D < 20·0 ng/ml, insufficiency as 20–29·9 ng/ml and sufficiency as ≥30 ng/ml. Of the 1500 individuals studied, 45 % were males and the mean age was 46 (sd 12) years. Vitamin D levels lowered with increasing degrees of glucose tolerance (NGT: 21 (sd 11); prediabetes: 19 (sd 10); T2DM: 18 (sd 11) ng/ml, P < 0·001). The overall prevalence of vitamin D deficiency was 55 % and was significantly higher among individuals with T2DM (63 %) followed by prediabetes (58 %) and NGT (51 %) (Pfor trend < 0·001). Women had 1·6 times the risk of vitamin D deficiency compared with men (unadjusted OR 1·6 (95 % CI 1·3, 2·0) and adjusted OR 1·6 (95 % CI 1·2, 1·9)). However, there was no increasing trend observed with increasing age. The prevalence of abdominal obesity (66 v. 49 %), generalised obesity (80 v. 64 %), the metabolic syndrome (45 v. 37 %) and insulin resistance (38 v. 27 %) was significantly higher in those with vitamin D deficiency compared with those without. This study shows that vitamin D deficiency is highly prevalent in this urban south Indian population and was higher among individuals with T2DM and prediabetes compared with those with NGT.

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“…The previous meta-analysis suggest that a low 25OHD is associated with thyroid disease, in particular autoimmune thyroiditis [48]. After adjusting for all these factors, there is a small positive correlation between HbA1c and 25OHD, as opposed to the results of Nur-Eke et al [49].…”

Section: Discussionmentioning

confidence: 83%

No Association between 25-Hydroxyvitamin D and Insulin Resistance or Thyroid Hormone Concentrations in a Romanian Observational Study

et al. 2020

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Background and objectives: Vitamin D is involved in insulin resistance through genomic and non-genomic mechanisms. Several observational and randomized studies have discrepant results; some of them showed an improved insulin resistance (IR), and others a neutral effect after vitamin D deficiency is corrected. Materials and Methods: We designed a retrospective observational study that included all women who presented for 33 months in an outpatient clinic in Bucharest, Romania. Results: We analyzed 353 patients with a mean age of 58.5 ± 13.7 years, a mean body mass index (BMI) of 27.36 ± 4.87 kg/m−2, and a mean level of 25-hydroxyvitamin D (25OHD) of 39.53 ± 15.73 ng/mL. There were no differences in the calculated Homeostatic Model Assessment of Insulin Resistance variants 1 and 2 (HOMA-IR) and the Quantitative Insulin Sensitivity Check Index (QUICKI) between women with vitamin D deficit versus normal values. In multivariate analysis, there was no significant relation between 25OHD and the response variables considered by us. Conclusions: We observed a small positive correlation between a higher level of 25OHD and increased glycosylated hemolobin (HbA1c) or IR indices without clinical significance. Other modifiable or non-modifiable factors override 25OHD influence on IR in adult women with a normal serum level and may contribute to the remainder of the variability observed.

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Pre-Diabetics with Hypovitaminosis D Have Higher Risk for Insulin Resistance

Cited by 7 publications

References 0 publications

Vitamin D levels, prediabetes risk and hemoglobin A1c levels in young non‐diabetic Saudi women

Vitamin D levels, prediabetes risk and hemoglobin A1c levels in young non‐diabetic Saudi women

Prevalence of vitamin D deficiency in urban south Indians with different grades of glucose tolerance

No Association between 25-Hydroxyvitamin D and Insulin Resistance or Thyroid Hormone Concentrations in a Romanian Observational Study

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