Pre-decapitation state of arousal of rats predetermines the effect of des-Tyr1-γ-endorphin on dopamine release from nucleus accumbens slices

Versteeg, Dirk H.G.; Heuven-Nolsen, D. van; Wied, D. de

doi:10.1016/0024-3205(84)90609-x

Cited by 7 publications

(2 citation statements)

References 19 publications

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“…In fact, removal of the N-terminal group of this substance eliminates opiate-like actions, and the resultant peptide (des-tyr)-gamma-endorphin (DTGE) resembles antipsychotic drugs in a number of tests. However, since this substance did not displace haloperidol from its binding site, it has been suggested that DTGE or a closely related peptide is an endogenous substance with anti-psychotic –like-action (176-177). …”

Section: Hypothesismentioning

confidence: 99%

Hypothesizing dopaminergic genetic antecedents in schizophrenia and substance seeking behavior

Blum¹,

Oscar‐Berman²,

Badgaiyan³

et al. 2014

Medical Hypotheses

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The dopamine system has been implicated in both substance use disorder (SUD) and schizophrenia. A recent meta- analysis suggests that A1 allele of the DRD2 gene imposes genetic risk for SUD, especially alcoholism and has been implicated in Reward Deficiency Syndrome (RDS). We hypothesize that dopamine D2 receptor (DRD2) gene Taq1 A2 allele is associated with a subtype of non- SUD schizophrenics and as such may act as a putative protective agent against the development of addiction to alcohol or other drugs of abuse. Schizophrenics with SUD may be carriers of the DRD2 Taq1 A1 allele, and/or other RDS reward polymorphisms and have hypodopaminergic reward function. One plausible mechanism for alcohol seeking in schizophrenics with SUD, based on previous research, may be a deficiency of gamma type endorphins that has been linked to schizophrenic type psychosis.. We also propose that alcohol seeking behavior in schizophrenics, may serve as a physiological self-healing process linked to the increased function of the gamma endorphins, thereby reducing abnormal dopaminergic activity at the nucleus accumbens (NAc). These hypotheses warrant further investigation and cautious interpretation. We, therefore, encourage research involving neuroimaging, genome wide association studies (GWAS), and epigenetic investigation into the relationship between neurogenetics and systems biology to unravel the role of dopamine in psychiatric illness and SUD.

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Section: Hypothesismentioning

confidence: 99%

Hypothesizing dopaminergic genetic antecedents in schizophrenia and substance seeking behavior

Blum¹,

Oscar‐Berman²,

Badgaiyan³

et al. 2014

Medical Hypotheses

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“…Other recent papers [e.g.. Esposito et al, 1984] have also sug gested a functional link between the endorphinergic and dopaminergic systems. Another study [ Versteeg et al, 1984] has shown that the predecapitation state of arousal in rats was directly related to the ability of dcs-tyrosine gamma-endorphin to release DA from nucleus accumbens preparations in vitro. A purely speculative extrapolation to learning and memory is that endorphin release (or opioid administration) will be coupled with DA stimulation to the extent that the organism is optimally aroused.…”

Section: Opioidsmentioning

confidence: 99%

A Psychopharmacological Perspective of Cognitive Functions

Wolkowitz

Tinklenberg

Weingartner³

1985

Neuropsychobiology

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In this article we review the effects of specific drugs or neurotransmitter systems on cognitive functions. While much of what we know about drugs’ effects on memory is derived from animal experiments, this review focusses on studies relevant to human clinical conditions. We conclude with a speculative analysis or taxonomy of the pharmacology of memory which broadly highlights the utility of viewing memory as being comprised of several differentiated processes.

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The neuroleptic-like peptide desenkephalin-γ-endorphin does not antagonize the dopamine receptor agonist-induced inhibition of the release of [3H]dopamine from rat nucleus accumbens slices in vitro

et al. 1987

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In rats, the non-opioid fl-endorphin (fiE) fragment desenkephalin-y-endorphin (DEyE, flE6_17 ) antagonizes the hypomotility induced by a small dose of dopamine (DA) receptor agonists. It has been suggested that DEyE might act in this respect by a direct or indirect blockade of presynaptically located DA receptors in the nucleus accumbens, thereby causing an increase of DA release. Therefore in the present study the effect of DEyE was examined on DA receptor agonist-induced inhibition of the electrically evoked release of previously accumulated [3H]DA from rat nucleus accumbens slices in vitro. The DA receptor agonists apomorphine, LY 171555 and n,n-di-n-propyl-7-hydroxy-2-aminotetralin (DP-7-AT) inhibited in a concentration-dependent manner the electrically evoked release of [3H]DA. The selective D 2 receptor antagonist (-)-sulpiride blocked the effects of apomorphine, corroborating that the DA receptor involved is of a D 2 type. DEyE was tested at several concentrations (10-9-10 -6 M) and under various experimental conditions. DEyE, by itself, did not affect either the electrically stimulated or the basal release of [3H]DA. The inhibiting effect of DA receptor agonists was slightly reduced by DEyE, but this effect was present in some experiments only. It is concluded that DEyE does not function as an antagonist for the DA receptor mediating DA release and that the interaction observed in behavioural experiments between DA agonists and DEyE does not occur at the level of this receptor.

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Pre-decapitation state of arousal of rats predetermines the effect of des-Tyr1-γ-endorphin on dopamine release from nucleus accumbens slices

Cited by 7 publications

References 19 publications

Hypothesizing dopaminergic genetic antecedents in schizophrenia and substance seeking behavior

Hypothesizing dopaminergic genetic antecedents in schizophrenia and substance seeking behavior

A Psychopharmacological Perspective of Cognitive Functions

The neuroleptic-like peptide desenkephalin-γ-endorphin does not antagonize the dopamine receptor agonist-induced inhibition of the release of [3H]dopamine from rat nucleus accumbens slices in vitro

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