1984
DOI: 10.1016/0024-3205(84)90609-x
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Pre-decapitation state of arousal of rats predetermines the effect of des-Tyr1-γ-endorphin on dopamine release from nucleus accumbens slices

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Cited by 7 publications
(2 citation statements)
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“…In fact, removal of the N-terminal group of this substance eliminates opiate-like actions, and the resultant peptide (des-tyr)-gamma-endorphin (DTGE) resembles antipsychotic drugs in a number of tests. However, since this substance did not displace haloperidol from its binding site, it has been suggested that DTGE or a closely related peptide is an endogenous substance with anti-psychotic –like-action (176-177). …”
Section: Hypothesismentioning
confidence: 99%
“…In fact, removal of the N-terminal group of this substance eliminates opiate-like actions, and the resultant peptide (des-tyr)-gamma-endorphin (DTGE) resembles antipsychotic drugs in a number of tests. However, since this substance did not displace haloperidol from its binding site, it has been suggested that DTGE or a closely related peptide is an endogenous substance with anti-psychotic –like-action (176-177). …”
Section: Hypothesismentioning
confidence: 99%
“…Other recent papers [e.g.. Esposito et al, 1984] have also sug gested a functional link between the endorphinergic and dopaminergic systems. Another study [ Versteeg et al, 1984] has shown that the predecapitation state of arousal in rats was directly related to the ability of dcs-tyrosine gamma-endorphin to release DA from nucleus accumbens preparations in vitro. A purely speculative extrapolation to learning and memory is that endorphin release (or opioid administration) will be coupled with DA stimulation to the extent that the organism is optimally aroused.…”
Section: Opioidsmentioning
confidence: 99%