Pre-Conditioning Methods and Novel Approaches with Mesenchymal Stem Cells Therapy in Cardiovascular Disease

Matta, Anthony; Nader, Vanessa; Lebrin, Marine; Gross, Fabian; Prats, Anne-Catherine; Cussac, Daniel; Galinier, Michel; Roncalli, Jérôme

doi:10.3390/cells11101620

Cited by 18 publications

(15 citation statements)

References 140 publications

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“…Moreover, O 2 breathing goes beyond mere therapeutic use. Breathing an O 2 mixture at different concentrations, either hypoxic or hyperoxic, has been used for sport training [ 9 ], cardiovascular conditioning [ 10 , 11 ], or before extreme environmental exposure, such as SCUBA diving [ 12 , 13 ], military high-altitude free fall [ 14 , 15 ], or space flight [ 16 , 17 ], to avoid the occurrence of decompression sickness (DCS).…”

Section: Introductionmentioning

confidence: 99%

Varying Oxygen Partial Pressure Elicits Blood-Borne Microparticles Expressing Different Cell-Specific Proteins—Toward a Targeted Use of Oxygen?

Balestra

Arya

Leveque

et al. 2022

IJMS

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Oxygen is a powerful trigger for cellular reactions, but there are few comparative investigations assessing the effects over a large range of partial pressures. We investigated a metabolic response to single exposures to either normobaric (10%, 15%, 30%, 100%) or hyperbaric (1.4 ATA, 2.5 ATA) oxygen. Forty-eight healthy subjects (32 males/16 females; age: 43.7 ± 13.4 years, height: 172.7 ± 10.07 cm; weight 68.4 ± 15.7 kg) were randomly assigned, and blood samples were taken before and 2 h after each exposure. Microparticles (MPs) expressing proteins specific to different cells were analyzed, including platelets (CD41), neutrophils (CD66b), endothelial cells (CD146), and microglia (TMEM). Phalloidin binding and thrombospondin-1 (TSP), which are related to neutrophil and platelet activation, respectively, were also analyzed. The responses were found to be different and sometimes opposite. Significant elevations were identified for MPs expressing CD41, CD66b, TMEM, and phalloidin binding in all conditions but for 1.4 ATA, which elicited significant decreases. Few changes were found for CD146 and TSP. Regarding OPB, further investigation is needed to fully understand the future applications of such findings.

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Section: Introductionmentioning

confidence: 99%

Varying Oxygen Partial Pressure Elicits Blood-Borne Microparticles Expressing Different Cell-Specific Proteins—Toward a Targeted Use of Oxygen?

Balestra

Arya

Leveque

et al. 2022

IJMS

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“…revealed that subcutaneous administration of human Wharton’s jelly-derived MSCs (WJ-MSCs) preconditioned with the Toll-like receptor 3 agonist poly I:C or IFN-γ can decrease the levels of proinflammatory cytokines in a murine model of AD. Moreover, they can ameliorate more epidermal thickness and inflammatory cell infiltration in skin lesions than non-preconditioned MSCs ( 73 ). Zhang et al.…”

Section: The Therapeutic Effects Of Preconditioning Mscs On Ad and Ps...mentioning

confidence: 99%

Therapeutic effects of mesenchymal stem cells and their derivatives in common skin inflammatory diseases: Atopic dermatitis and psoriasis

Yang

Xiao

et al. 2023

Front. Immunol.

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Chronic skin inflammatory diseases including atopic dermatitis (AD) and psoriasis have been considered uncontrolled inflammatory responses, which have usually troubled patients around the world. Moreover, the recent method to treat AD and psoriasis has been based on the inhibition, not regulation, of the abnormal inflammatory response, which can induce a number of side effects and drug resistance in long-term treatment. Mesenchymal stem/stromal cells (MSCs) and their derivatives have been widely used in immune diseases based on their regeneration, differentiation, and immunomodulation with few adverse effects, which makes MSCs a promising treatment for chronic skin inflammatory diseases. As a result, in this review, we aim to systematically discuss the therapeutic effects of various resources of MSCs, the application of preconditioning MSCs and engineering extracellular vesicles (EVs) in AD and psoriasis, and the clinical evaluation of the administration of MSCs and their derivatives, which can provide a comprehensive vision for the application of MSCs and their derivatives in future research and clinical treatment.

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“…However, there are several conditions that can damp MSC capabilities of healing in situ. Autologous transplantations of MSC have mild results in clinical trials despite animal models generated great results [68]. Allogeneic transplantation of MSCs seems to have better outcomes.…”

Section: Mesenchymal Stromal Cell Dysfunctionmentioning

confidence: 99%

Activation and Metabolic Shifting: An Essential Process to Mesenchymal Stromal Cells Function

Semedo-Kuriki¹,

Pereira²,

Almeida³

et al. 2023

Possibilities and Limitations in Current Translational Stem Cell Research

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To elucidate the basal metabolism of Mesenchymal Stromal Cells (MSCs), as well as knowing how they are activated, can bring important clues to a successful cell-based therapy. Naive MSCs, in their niche, mainly keep the local homeostasis and the pool of tissue stem cells. Once activated, by an injury, MSCs’ response leads to a lot of physiological differences in its metabolism that are responsible for its healing process. Since endogenous MSC seems to be ineffective in pathologic and aging conditions, cell-based therapy using MSC is focused on administration of exogenous MSC in patients to exert its healing functions. From quiescent to activated state, this “Metabolic Shifting” of MSC interferes directly in its secretion and cellular-derived particle generation. We will address here the differences between the MSCs activation phases and how they can modify the MSCs metabolism and its function. Moreover, understanding MSC in their niche and its damped function in pathologic and aging processes can improve stem cell-based therapies.

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Pre-Conditioning Methods and Novel Approaches with Mesenchymal Stem Cells Therapy in Cardiovascular Disease

Cited by 18 publications

References 140 publications

Varying Oxygen Partial Pressure Elicits Blood-Borne Microparticles Expressing Different Cell-Specific Proteins—Toward a Targeted Use of Oxygen?

Varying Oxygen Partial Pressure Elicits Blood-Borne Microparticles Expressing Different Cell-Specific Proteins—Toward a Targeted Use of Oxygen?

Therapeutic effects of mesenchymal stem cells and their derivatives in common skin inflammatory diseases: Atopic dermatitis and psoriasis

Activation and Metabolic Shifting: An Essential Process to Mesenchymal Stromal Cells Function

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