Pre-conceptional and prenatal exposure to pesticides and pediatric neuroblastoma. A meta-analysis of nine studies

Khan, Aiza; Feulefack, Joseph; Sergi, Consolato

doi:10.1016/j.etap.2021.103790

Cited by 18 publications

(13 citation statements)

References 45 publications

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“…Case-control studies were included in the meta-analysis in analogy to another study targeting neuroblastoma and pesticide exposure published in this journal, 33 and pediatric brain tumor and pesticide exposure published in another journal. 34 The following study designs were excluded: cohort studies, reviews, abstracts, opinions, case reports, letters, meta-analysis, and pool analysis.…”

Section: Study Selection Methods and Criteriamentioning

confidence: 99%

Exposure to pesticides and pediatric Wilms’ tumor. A meta-analysis on pre-conception and pregnancy parental exposure with an IARC/WHO commentary

2022

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Background There are hereditary types of nephroblastoma or Wilms’ tumor associated with exposure of the germ cells of either parent to harmful environmental factors. Some studies have examined the exposure of compounds used pesticides and herbicides as a risk factor for Wilms’ tumor. Methods A systematic review and meta-analysis were carried out on case-control studies to establish the potential link between exposure to these organic molecules and Wilms’ tumor occurrence in children rigorously. We examined the monographs on some organo-phosphate insecticides and herbicides issued by the International Association for the Research on Cancer (IARC) under the auspices of the World Health Organization (WHO). PUBMED, SCOPUS, and Google Scholar studies (1960–2021) were identified and systematically reviewed following Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. Subgroup analyses were conducted after stratification for occupational versus residential exposure and before birth (prenatal) vs. after birth (postnatal) exposure. In addition, we revised the monographs on chemical compounds issued recently by the IARC/WHO. Results Our findings seem to consolidate that parental pesticide exposure during the preconception or pregnancy period is correlated with an increased occurrence risk for Wilms’ tumor. We confirm the validity of the WHO essays on certain organophosphate herbicides and insecticides, which support these compounds, may be highly relevant in future cancer prevention policies. Conclusion Parental exposure to pesticides, particularly in household settings, is poorly emphasized in our society. There is a strong association between these organophosphate compounds and pediatric cancer. Public health agencies may need to take stronger action than in the past.

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Section: Study Selection Methods and Criteriamentioning

confidence: 99%

Exposure to pesticides and pediatric Wilms’ tumor. A meta-analysis on pre-conception and pregnancy parental exposure with an IARC/WHO commentary

2022

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“…Neuroblastoma mostly affects children under the age of five and is the most common type of neoplasm in children under the age of 1. A recent meta-analysis suggests that pre-conception and prenatal parental exposure to pesticides is linked to increased rates of these pediatric tumors [68]. Overall, the associations between exposures to pesticides are stronger for children diagnosed after the age of one compared with infants in another study [69].…”

Section: Neuroblastomamentioning

confidence: 98%

Epigenetic Inheritance: Intergenerational Effects of Pesticides and Other Endocrine Disruptors on Cancer Development

Nicolella

Assis

2022

IJMS

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Parental environmental experiences affect disease susceptibility in the progeny through epigenetic inheritance. Pesticides are substances or mixtures of chemicals—some of which are persistent environmental pollutants—that are used to control pests. This review explores the evidence linking parental exposure to pesticides and endocrine disruptors to intergenerational and transgenerational susceptibility of cancer in population studies and animal models. We also discuss the impact of pesticides and other endocrine disruptors on the germline epigenome as well as the emerging evidence for how epigenetic information is transmitted between generations. Finally, we discuss the importance of this mode of inheritance in the context of cancer prevention and the challenges ahead.

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“…Neuroblastoma has an incidence of 10.5 per million in children under 15 years of age, but the rates keep increasing and the role of pesticides and insecticides during blastogenesis or the parental exposure has been recently suggested (4)(5)(6).…”

Section: Introductionmentioning

confidence: 99%

In Situ Neuroblastoma: The Intriguing “Tumor” of Neuroectodermal Origin and the Putative Cancer Stem Cells

Sergi¹

2023

Advancements in Cancer Research

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Neuroblastoma is the most prevalent solid tumor encountered outside of the central nervous system in infancy. It is considered an embryonal tumor arising from pluripotent sympathetic cells called neuroblasts with characteristic neurosecretory granules. They are positive for chromogranin A, and are double membrane bounded ultra-structurally. In rare occurrences, it can be identified at neonatal age or at very early infancy. In situ labelling of neuroblastoma has been used, but there is a remarkable controversy around it, because most of these clusters of neuroblastic cells do not exhibit a neoplastic potential. These clusters often regress, and these pediatric patients should not receive chemotherapy. This chapter reviews the challenges of this tumor and report on the heterogeneity of this kind of pediatric neoplasm with a focus on putative cancer stem cells.

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Pre-conceptional and prenatal exposure to pesticides and pediatric neuroblastoma. A meta-analysis of nine studies

Cited by 18 publications

References 45 publications

Exposure to pesticides and pediatric Wilms’ tumor. A meta-analysis on pre-conception and pregnancy parental exposure with an IARC/WHO commentary

Exposure to pesticides and pediatric Wilms’ tumor. A meta-analysis on pre-conception and pregnancy parental exposure with an IARC/WHO commentary

Epigenetic Inheritance: Intergenerational Effects of Pesticides and Other Endocrine Disruptors on Cancer Development

In Situ Neuroblastoma: The Intriguing “Tumor” of Neuroectodermal Origin and the Putative Cancer Stem Cells

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