Pre-conception serum ferritin concentrations are associated with metal concentrations in blood during pregnancy: A cohort study in Benin

Davies, Sarah; Briand, Valérie; Fiévet, Nadine; Bot, Barbara Le; Durand, Séverine; Agbota, Gino; Yovo, Emmanuel; Vianou, Bertin; Sossou, Darius; Martin‐Prével, Yves; Massougbodji, Achille; Cot, Michel; Glorennec, Philippe; Bodeau-Livinec, Florence

doi:10.1016/j.envres.2021.111629

Cited by 9 publications

(6 citation statements)

References 48 publications

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“…Analyses of Hg were performed at the laboratory of LERES (Laboratoire d'Etude et de Recherche en Environnement et Santé) at the French School of Public Health—EHESP (Rennes, France), following the procedures described by Davies et al 30 . The 161 serum samples were analysed by a plasma torch coupled with tandem mass spectrometer (ICP-MSMS 8800, Agilent Technologies) after a mineralisation step by adding nitric acid and heated with a heating block (Hotblock Pro, model SC-189, Environmental Express) at 83 °C for 4 h. Matrix effects correction was guaranteed through the use of internal standards (Sc, Ge, 77Se, Rh, Re and Ir).…”

Section: Methodsmentioning

confidence: 99%

Exposure profiles in pregnant women from a birth cohort in a highly contaminated area of southern Italy

Drago,

Ruggieri,

Sprovieri

et al. 2023

Sci Rep

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Protecting the health of pregnant women from environmental stressors is crucial for reducing the burden of non-communicable diseases. In industrially contaminated sites, this action is particularly challenging due to the heterogeneous pollutant mixtures in environmental matrices. The aim of this study was to evaluate distribution patterns of mercury, hexachlorobenzene and polychlorobiphenyls in the serum of 161 pregnant women recruited in the framework of the Neonatal Environment and Health Outcomes (NEHO) cohort and living both inside and outside the National Priority Contaminated Site (NPCS) of Priolo. Food macro-categories were determined, and serum levels of contaminants were used to perform k-means cluster analysis and identify the role of food in pollutant transfer from the environment. Two groups of mothers with high and low measured pollutant levels were distinguished. Concentrations in mothers in the high-exposure cluster were at least twofold for all the evaluated pollutants (p < 0.0001) and included mothers living inside and outside NPCS, with a predominance of individuals from the NPCS (p = 0.045). Fish consumption was higher in the high-exposure cluster (p = 0.019). These findings suggest a link between contamination of environmental matrices such as sediment with maternal exposure, through the intake of local food. Such consideration appears poorly investigated in the context of contaminated sites.

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Section: Methodsmentioning

confidence: 99%

Exposure profiles in pregnant women from a birth cohort in a highly contaminated area of southern Italy

Drago,

Ruggieri,

Sprovieri

et al. 2023

Sci Rep

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show abstract

“…Several studies show inverse associations between blood ferritin with toxic metals (including Pb and Cd) in adults and children [83][84][85]. Lower preconception serum ferritin concentrations were associated with higher concentrations of Cd and Pb in the first trimester [86] while a longitudinal study observed that urinary Cd increased throughout pregnancy as iron stores were depleted [87]. In a national level population-based survey of Korean females over 10 years of age, lower serum 25OHD concentrations levels were associated with iron deficiency anemia and increased Cd concentrations in blood [82].…”

Section: Intestinal Absorption Of Toxic Cations -Low Vitamin D Status...mentioning

confidence: 99%

Vitamin D and Toxic Metals in Pregnancy - a Biological Perspective

Fisher,

Weiler,

Kuiper

et al. 2024

Curr Epidemiol Rep

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Purpose of Review To discuss the potential biological mechanisms between vitamin D and toxic metals and summarize epidemiological studies examining this association in pregnant women. Recent Findings We identified four plausible mechanisms whereby vitamin D and toxic metals may interact: nephrotoxicity, intestinal absorption of metals, endocrine disruption, and oxidative stress. Few studies have examined the association between vitamin D and toxic metals in pregnant women. North American studies suggest that higher vitamin D status early in pregnancy are associated with lower blood metals later in pregnancy. However, a trial of vitamin D supplementation in a pregnant population, with higher metal exposures and lower overall nutritional status, does not corroborate these findings. Summary Given ubiquitous exposure to many toxic metals, nutritional intervention could be a means for prevention of adverse outcomes. Future prospective studies are needed to establish a causal relationship and clarify the directionality of vitamin D and metals.

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“…Lipid-standardised organochlorine concentrations were calculated from wet weight concentrations divided by total lipids. Analyses of Hg were performed at the laboratory of LERES (Laboratoire d'Etude et de Recherche en Environnement et Santé) at the French School of Public Health -EHESP (Rennes, France), following the procedures described by Davies et al (2021). The 161 serum samples were analysed by a plasma torch coupled with tandem mass spectrometer (ICP-MSMS 8800, Agilent Technologies) after a mineralisation step by adding nitric acid and heated with a heating block (Hotblock Pro, model SC-189, Environmental Express) at 83°C for 4 hours.…”

Section: Analytical Proceduresmentioning

confidence: 99%

Exposure profiles in pregnant women from a birth cohort in a highly contaminated area of southern Italy

Drago¹,

Ruggieri²,

Sprovieri

et al. 2022

Preprint

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Protecting the health of pregnant women from environmental stressors is crucial for reducing the burden of non-communicable diseases. In industrially contaminated sites, this action is particularly challenging due to the heterogeneous pollutant mixtures in environmental matrices. Aim of this study was to evaluate distribution patterns of mercury, hexacholobenzene and polychlorobyfenils in the serum of 161 pregnant women recruited in the framework of the NEHO cohort and living both inside and outside the National Priority Contaminated Site (NPCS) of Priolo. Food macro-categories were determined, and serum levels of contaminants were used to perform k-means cluster analysis and identify the role of food in pollutant transfer from the environment. Two groups of mothers with high and low measured pollutant levels were distinguished. Concentrations in mothers in the high-exposure cluster were at least twofold for all the evaluated pollutants (p<0.0001) and includes mothers living inside and outside NPCS, with predominance of individuals from the NPCS (p=0.045). Fish and vegetable consumption was higher in the high-exposure cluster (p=0.02). These findings suggest a direct link between marine sediments and soil contaminations, which in turn drives maternal exposure through the food chain. Such consideration appears poorly investigated in the context of contaminated sites.

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Pre-conception serum ferritin concentrations are associated with metal concentrations in blood during pregnancy: A cohort study in Benin

Cited by 9 publications

References 48 publications

Exposure profiles in pregnant women from a birth cohort in a highly contaminated area of southern Italy

Exposure profiles in pregnant women from a birth cohort in a highly contaminated area of southern Italy

Vitamin D and Toxic Metals in Pregnancy - a Biological Perspective

Exposure profiles in pregnant women from a birth cohort in a highly contaminated area of southern Italy

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