Pre-conception exposure to THC fails to impact nicotine reward in adult offspring

Hempel, Briana; Melkumyan, Mariam; Crissman, Madeline E.; Winston, Chloe A.; Madar, Jacob; Riley, Anthony L.

doi:10.1016/j.pbb.2020.173001

Cited by 4 publications

(1 citation statement)

References 54 publications

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“…On the other hand, recent work has shown that parental exposure to cannabinoids alters the rewarding properties of other drugs of abuse in the subsequent generation. Nevertheless, preconception THC administration in male and female rats did not modify the reinforcing properties of nicotine in adult offspring [ 184 ], suggesting that these cross-generational effects could be drug-specific.…”

Section: Effects Of Cannabinoid Exposure On Nicotine Addictive Propertiesmentioning

confidence: 99%

New Insights in the Involvement of the Endocannabinoid System and Natural Cannabinoids in Nicotine Dependence

Saravia

Ten-Blanco

Pereda-Pérez

et al. 2021

IJMS

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Nicotine, the main psychoactive component in tobacco smoke, plays a major role in tobacco addiction, producing a high morbidity and mortality in the world. A great amount of research has been developed to elucidate the neural pathways and neurotransmitter systems involved in such a complex addictive behavior. The endocannabinoid system, which has been reported to participate in the addictive properties of most of the prototypical drugs of abuse, is also implicated in nicotine dependence. This review summarizes and updates the main behavioral and biochemical data involving the endocannabinoid system in the rewarding properties of nicotine as well as in nicotine withdrawal and relapse to nicotine-seeking behavior. Promising results from preclinical studies suggest that manipulation of the endocannabinoid system could be a potential therapeutic strategy for treating nicotine addiction.

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Section: Effects Of Cannabinoid Exposure On Nicotine Addictive Propertiesmentioning

confidence: 99%

New Insights in the Involvement of the Endocannabinoid System and Natural Cannabinoids in Nicotine Dependence

Saravia

Ten-Blanco

Pereda-Pérez

et al. 2021

IJMS

View full text Add to dashboard Cite

show abstract

Ethanol pre-exposure differentially impacts the rewarding and aversive effects of α-pyrrolidinopentiophenone (α-PVP): Implications for drug use and abuse

Nelson

Manke

Bailey

et al. 2021

Pharmacology Biochemistry and Behavior

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Cross-generational THC Exposure Weakly Attenuates Cocaine's Rewarding Effects in Adult Male Offspring

Hempel

Crissman

Imanalieva

et al. 2020

Physiology & Behavior

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Pre-conception exposure to THC fails to impact nicotine reward in adult offspring

Cited by 4 publications

References 54 publications

New Insights in the Involvement of the Endocannabinoid System and Natural Cannabinoids in Nicotine Dependence

New Insights in the Involvement of the Endocannabinoid System and Natural Cannabinoids in Nicotine Dependence

Ethanol pre-exposure differentially impacts the rewarding and aversive effects of α-pyrrolidinopentiophenone (α-PVP): Implications for drug use and abuse

Cross-generational THC Exposure Weakly Attenuates Cocaine's Rewarding Effects in Adult Male Offspring

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