Pre-Columbian rhinoscleroma

Goldman, L.

doi:10.1001/archderm.115.1.106b

Cited by 6 publications

(3 citation statements)

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“…14 The first historic evidence of patients with scleroma was of a Mayan Indian terracotta head dated between 300 and 600 AD, which depicted typical nasal proliferate lesions of this disease. 15,16 A positive culture in MacConkey agar is diagnostic of RS, but it is positive in only 50% to 60% of patients. The diagnosis is confirmed by histology.…”

Section: Discussionmentioning

confidence: 99%

Topical Mitomycin C as an Adjunct to Surgical Debulking and Medical Treatment in Rhinoscleroma

Awad

Hammad

2015

Am J Rhinol�Allergy

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Section: Discussionmentioning

confidence: 99%

Topical Mitomycin C as an Adjunct to Surgical Debulking and Medical Treatment in Rhinoscleroma

Awad

Hammad

2015

Am J Rhinol�Allergy

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“…Respiratory scleroma (RS) is a rare granulomatous chronic infectious disease affecting primarily the nose and upper respiratory tract (Ahmed, El‐Badawy, Mohamed, & Abdelhameed, ). Early historical evidence of RS is depicted in a Mayan terracotta head dated 300 to 600 AD (Goldman, ). This condition was first described by Von Hebra in 1,870 as “scleroma” or “rhinoscleroma”; it is associated with Klebsiella pneumonia subsp.…”

Section: Introductionmentioning

confidence: 99%

Respiratory scleroma: A clinicopathologic study of 51 cases from Guatemala

et al. 2020

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Objectives To evaluate clinical and pathologically cases of respiratory scleroma diagnosed in a 30‐year period in Guatemala. Material and methods Fifty‐one cases of respiratory scleroma diagnosed from 1988 to 2018 in a single pathology service in Guatemala were confirmed using Warthin–Starry staining. Immunohistochemical reactions against CD68, LCA, CD20, CD3, and CD138 were performed to illustrate the inflammatory infiltrate. Scanning electron microscopy (SEM) was performed to illustrate bacteria morphology. Results All 51 cases affected patients from poor areas of Guatemala, particularly women (66.7%), with a mean age of 31 years (range 7–66 years). Nose was affected in most cases (96.1%). Other sites involved included pharynx, larynx, palate, maxillary sinuses, and upper lip. Depending on the stage, the disease manifested as ulcerations, nasal deformities, or laryngeal stenosis. Nasal obstruction, epistaxis, dysphonia, fetid discharge, and pain were the main symptoms. Mikulicz cells (CD68+) in a plasma cell‐rich inflammatory background (CD138+, CD20+, CD3+/−) were the typical microscopic presentation. In SEM, each macrophagic vacuole contained few to dozens of Klebsiella rhinoscleromatis diplobacilli. Treatment consisted of long‐term trimethoprim and sulfamethoxazole, with adequate control of disease. Conclusion Respiratory scleroma is a rare infectious disease affecting the upper respiratory tract, in poor regions of the world, including Guatemala.

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“…More recently, it has been reported in poorer regions of Central Africa, Eastern and Central Europe, the Middle East, India and Indonesia. There are also cases in non‐endemic areas that are explainable by increased migration 3–5 …”

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confidence: 99%