Pre-Clinical Study of In Vivo Magnetic Resonance-Guided Bubble-Enhanced Heating in Pig Liver

Elbes, Delphine; Denost, Quentin; Laurent, Césari; Trillaud, Hervé; Rullier, Anne; Quesson, Bruno

doi:10.1016/j.ultrasmedbio.2013.01.014

Cited by 17 publications

(10 citation statements)

References 44 publications

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“…Previous work with cavitation-enhanced heating and MR temperature imaging has observed that the maximal point of heating can migrate towards the transducer due to reflections from a bubble cloud (Elbes et al , 2013; Sokka et al , 2003). Here, the thermometry was obtained in the focal plane (i.e., imaging oriented perpendicular to the direction of ultrasound beam propagation), and the heated region could have migrated out of the imaging plane during the 30 s sonications without our knowledge.…”

Section: Discussionmentioning

confidence: 99%

Cavitation-enhanced MR-guided focused ultrasound ablation of rabbit tumorsin vivousing phase shift nanoemulsions

Kopechek¹,

Park²,

Zhang³

et al. 2014

Phys. Med. Biol.

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Advanced tumors are often inoperable due to their size and proximity to critical vascular structures. High intensity focused ultrasound (HIFU) has been developed to non-invasively thermally ablate inoperable solid tumors. However, the clinical feasibility of HIFU ablation therapy has been limited by the long treatment times (on the order of hours) and high acoustic intensities required. Studies have shown that inertial cavitation can enhance HIFU-mediated heating by generating broadband acoustic emissions that increase tissue absorption and accelerate HIFU-induced heating. Unfortunately, initiating inertial cavitation in tumors requires high intensities and can be unpredictable. To address this need, phase-shift nanoemulsions (PSNE) have been developed. PSNE consist of lipid-coated liquid perfluorocarbon droplets that are less than 200 nm in diameter, thereby allowing passive accumulation in tumors through leaky tumor vasculature. PSNE can be vaporized into microbubbles in tumors in order to nucleate cavitation activity and enhance HIFU-mediated heating. In this study, MR-guided HIFU treatments were performed on intramuscular rabbit VX2 tumors in vivo to assess the effect of vaporized PSNE on acoustic cavitation and HIFU-mediated heating. HIFU pulses were delivered for 30 seconds using a 1.5 MHz, MR-compatible transducer, and cavitation emissions were recorded with a 650-kHz ring hydrophone while temperature was monitored using MR thermometry. Cavitation emissions were significantly higher (P<0.05) after PSNE injection and this was well correlated with enhanced HIFU-mediated heating in tumors. The peak temperature rise induced by sonication was significantly higher (P<0.05) after PSNE injection. For example, the mean percent change in temperature achieved at 5.2 W of acoustic power was 46 ± 22% with PSNE injection. The results indicate that PSNE nucleates cavitation which correlates with enhanced HIFU-mediated heating in tumors. This suggests that PSNE could potentially be used to reduce the time and/or acoustic intensity required for HIFU-mediated heating, thereby increasing the feasibility and clinical efficacy of HIFU thermal ablation therapy.

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Section: Discussionmentioning

confidence: 99%

Cavitation-enhanced MR-guided focused ultrasound ablation of rabbit tumorsin vivousing phase shift nanoemulsions

Kopechek¹,

Park²,

Zhang³

et al. 2014

Phys. Med. Biol.

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“…One should also note in this study that we used not more than 135 acoustic watt. Literature reports 67,68 mention significantly larger acoustic powers in vivo (ie between 300W and 800W).…”

Section: Perspectivesmentioning

confidence: 99%

Micron-sized PFOB liquid core droplets stabilized with tailored-made perfluorinated surfactants as a new class of endovascular sono-sensitizers for focused ultrasound thermotherapy

et al. 2019

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“…In one such study, Elbes et al (2013Elbes et al ( , 2014 demonstrated the feasibility of increasing the heating efficiency for treating liver tumors by exploiting cavitation-enhanced heating in pig livers using a clinical HIFU platform (Fig. 4.24).…”

Section: Preclinical Evaluation Of Cavitation-enhanced Thermal Effectsmentioning

confidence: 99%

Cavitation-Enhanced Thermal Effects and Applications

Zhang

Wan

Haar

2015

Cavitation in Biomedicine

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Pre-Clinical Study of In Vivo Magnetic Resonance-Guided Bubble-Enhanced Heating in Pig Liver

Cited by 17 publications

References 44 publications

Cavitation-enhanced MR-guided focused ultrasound ablation of rabbit tumorsin vivousing phase shift nanoemulsions

Cavitation-enhanced MR-guided focused ultrasound ablation of rabbit tumorsin vivousing phase shift nanoemulsions

Micron-sized PFOB liquid core droplets stabilized with tailored-made perfluorinated surfactants as a new class of endovascular sono-sensitizers for focused ultrasound thermotherapy

Cavitation-Enhanced Thermal Effects and Applications

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